Clinical case of failure of josamycin in a patient with urethritis caused by Mycoplasma genitalium

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Abstract


Mycoplasma genitalium is one of the obligate pathogens that cause sexually transmitted diseases. To detect this pathogen in routine practice, only molecular genetic methods are used that are also used to identify the resistance of MGE to antibiotics. The first-line drugs for the treatment of diseases caused by MGE, are tetracycline and macrolides. In recent years, many countries have increasingly recorded cases of unsuccessful therapy macrolides. Mutations that confer antibiotic resistance to macrolides for Mycoplasm genitalium are concentrated in nucleotide positions 2058 and 2059 in region V of the 23S rRNA gene. Unknown status of macrolide resistance M. genitalium can lead to the development of a persistent infection. We describe the first reported cases of clinical josamycin treatment failure from patient with ure - thritis. The reason for antibiotic resistance was a mutation in the 23S rRNA of MGE as a nucleotide substitution in position A2058G.


L. M. Zubareva

Smolensk Dermatovenerologic Dispensar y

Author for correspondence.
Email: ludmila-zubareva@mail.ru
ORCID iD: 0000-0001-8761-7852

Russian Federation

Clinical Laboratory Diagnostics Doctor

Rylenkova str., 16а, Smolensk, 214031, Russian Federation

I. A. Eydel’shteyn

Scientific Research Institute of Antimicrobial Chemotherapy of the Smolensk State Medical University

Email: InnaEdelstein@antibiotic.ru

Russian Federation

Cand. Sci. (Biol.), Laboratory Head, Laboratory of Molecular Diagnostics

Krupskoy str., 28, Smolensk, 214019, Russian Federation

A. V. Romanov

Scientific Research Institute of Antimicrobial Chemotherapy of the Smolensk State Medical University

Email: fake@neicon.ru

Russian Federation

Junior Researcher, Laboratory of Molecular Diagnostics, Scientific Research Institute of Antimicrobial Chemotherapy

Krupskoy str., 28, Smolensk, 214019, Russian Federation

V. V. Evstaf’ev

Smolensk Dermatovenerologic Dispensar y

Email: smolkvd@yandex.ru

Russian Federation

Head Doctor, Smolensk Dermatovenerologic Dispensary; Assoc. Prof., Department of Skin and Venereal Diseases

Rylenkova str., 16а, Smolensk, 214031, Russian Federation

R. S. Kozlov

Scientific Research Institute of Antimicrobial Chemotherapy of the Smolensk State Medical University

Email: fake@neicon.ru

Russian Federation

Dr. Sci. (Med.), Prof., Chief External Expert, Ministry of Health of Russian Federation on Clinical Microbiology and Antimicrobial Resistance; Director, Scientific Research Institute of Antimicrobial Chemotherapy of the Smolensk State Medical University; President of IACMAC; Acting Rector

Krupskoy str., 28, Smolensk, 214019, Russian Federation

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