Vol 89, No 6 (2013)

New regulations for authors of publications to be published in vestnik dermatologii i venerologii. Conflict of interest: condicio sine qua non
 
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Vestnik dermatologii i venerologii. 2013;89(6):18-23
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Incidence of congenital syphilis in Russian Federation in 2002—2012
 
Abstract
The paper presents the assessment of dynamics of congenital syphilis incidence in Russian Federation in 2002—2012, and results of the activities, aimed to decrease the incidence of congenital syphilis.
Vestnik dermatologii i venerologii. 2013;89(6):24-31
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Extracellular matrix of the skin: role in the development of dermatological diseases
 
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Extracellular matrix is a system of proteins and polysaccharides maintaining the structural integrity of an organ or tissue. At the same time, in addition to its “classical” function extracellular matrix components regulate many important processes including participation in the signal transmission, regulation of cell division and differentiation, which makes extracellular matrix molecules a prospective target for treatment of a lot of diseases.
Vestnik dermatologii i venerologii. 2013;89(6):32-39
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Current methods for preventing the development of cervical cancer in patients with papilloma viral infection
 
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The article presents the results of recent studies of the role of human papillomavirus in potentiating cancer in the cervix. the authors describe methods for organizing efforts aimed at early diagnostics of cancer pathologies associated with papilloma viral infection. they describe aspects of the prevention of cervical cancer in Russia and abroad. they also disclose current screening strategies related to cancer pathologies of the cervix based on a combination of diagnostics methods.
Vestnik dermatologii i venerologii. 2013;89(6):40-48
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Association of polymorphisms in TNFAIP3 and TNIPI genes with predisposition to the development of psoriasis in the Russian population
 
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Goal. To study polymorphisms in TNFAIP3 (rs610604) and TNIPI (rs17728338) genes in a sample of psoriasis patients and healthy volunteers from the Russian Federation. Materials and methods. By using allele specific hybridization methods in the form of real-time PCR and RFLP assay (Restriction Fragment Length Polymorphism), single-nucleotide polymorphisms of fragments of the following genes associated with predisposition to the development of psoriasis were studied in whole blood samples taken from psoriasis patients (n = 286) and healthy volunteers (n = 89): TNFAIP3 (rs610604) and TNIPI (rs17728338). Results. Psoriasis patients had a reliable increase in the frequency of the A/C heterozygous genotype of rs610604 polymorphism of the TNFAIP3 gene and A allele of rs17728338 polymorphism of the TNIP1 gene (A/G and A/A genotypes), which makes it possible to treat carriers of these genotypes as people with predisposition to the development of psoriasis, and to treat A/C genotypes of rs610604 polymorphism and A/G and A/A genotypes of rs17728338 polymorphism as predictors of the development of psoriasis in the Russian population. Conclusion. these data broaden the perception of genetic factors associated with the development of psoriasis in persons from the Russian population.
Vestnik dermatologii i venerologii. 2013;89(6):49-53
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Pathogenic value of neuropeptides and growth factor proteins for the development of inflammation and itching in patients with prevalent dermatoses
 
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Goal. To determine the value of neuropeptides and growth factor proteins for the development of inflammation and itching in patients with atopic dermatitis and psoriasis. Materials and methods. There was a study of 13 patients with atopic dermatitis, 28 patients with psoriasis and eleven healthy volunteers. The severity and prevalence of the skin lesion in patients with atopic dermatitis was compared using the SCORAD score, and in psoriatic patients — using the PASI index. The extent of itching was assessed using a visual analog scale. The level of neuropeptides in blood serum of the subjects was determined using the enzyme-linked immunoelectrodiffusion assay: substance P and calcitonin gene-related peptide as well as nerve growth factor, amphiregulin, an epidermal growth factor, and semaphorin 3A, a nerve repulsion factor. Results. A statistically significant increase in the level of nerve growth factors in blood serum of patients with atopic dermatitis was observed (91.37 ± 16.39 pg/mL) vs. the control group (10.68 ± 8.37 pg/mL) (p < 0.05) as well as increased level of amphiregulin (46.09 ± 5.22 pg/mL) vs. the control group (10.21 ± 2.10) (p < 0.05). A positive correlation between the level of the nerve growth factor and SCORAD score was revealed. Conclusion. The results obtained confirm that nerve growth factors and amphiregulin are involved in the pathogenesis of atopic dermatitis.
Vestnik dermatologii i venerologii. 2013;89(6):54-58
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Studying of the expression of PERP protein in the skin of patients with pemphigus
 
Abstract
The authors disclosed the participation of apoptosis proteins in the development of acantholysis in patients with pemphigus. In this connection, studies of the PERP protein passing apoptosis signals and regulating desmosomal functions in keratinocytes are of interest. There is no information about any studies aimed at the PERP protein expression in patients with pemphigus in available literature. Goal. To assess the PERP protein expression in the skin of patients with pemphigus. Materials and methods. There was a study of 22 patients with pemphigus, a patient with bullous pemphigoid and ten healthy people. The PERP protein expression was studied in the biopsy materials obtained from lesion foci and apparently healthy skin of the patients as well as healthy people using the indirect immunofluorescence method. Results. The PERP protein expression was revealed in patients with pemphigus on areas of apparently intact skin, in lesion foci in the patient with bullous pemphigoid and skin of healthy volunteers in the membrane of keratinocytes from all epidermal layers.The PERP protein expression in the blister operculum in lesion foci in patients with pemphigus was absent. Conclusion. Substantial differences in the PERP protein expression in the blister operculum and apparently intact skin of patients with pemphigus were revealed.
Vestnik dermatologii i venerologii. 2013;89(6):59-65
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Diagnostics of early forms of syphilis by the chemiluminescence immunoassay method
 
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Goal. Assessment of the diagnostic efficacy of the chemiluminescence immunoassay (CLIA) method for early forms of acquired syphilis. Materials and methods. The authors examined 237 blood serum samples taken from patients suffering from primary (49), secondary (116) and latent early (72) syphilis as well as from 61 healthy blood donors and 20 persons with false-positive results of serological tests for syphilis. Blood serum samples were tested with the use of CLIA, EIA, passive hemagglutination test, immunofluorescence test and microprecipitation test methods. Results. The authors established that the CLIA method used for diagnostics of early forms of acquired syphilis (when the IMMULITE® 2000 Syphilis Screen test system is used) is characterized by high sensitivity (99.6%), specificity (95.1%), diagnostic efficacy (98.3%), predictive value of positive (95.1%) and negative (98.3%) results, which is sufficient for recommending this method as the screening method for diagnostics of syphilis to be used in large diagnostic centers. The CLIA method may also be used to confirm the diagnosis of syphilis. Conclusion. Based on these results, the authors developed a reverse algorithm for diagnostics of early forms of acquired syphilis beginning with the use of the CLIA method with further use of the nontreponemal method (microprecipitation reaction or other nontreponemal method).
Vestnik dermatologii i venerologii. 2013;89(6):66-72
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Production and evaluation of the clinical efficacy of the recombinant T. pallidum antigen Tp0453 for syphilis diagnosis
 
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Goal. Production of a recombinant T. pallidum antigen Tp0453 and the evaluation of the efficacy of its clinical use for syphilis diagnosis. Materials and methods. To produce the target recombinant T. pallidum antigen, a Tp0453 protein coding fragment of the DNA of the causative agent of syphilis, was cloned into the pET28а vector. Heterological expression of the recombinant T. pallidum antigen was performed in the E. coli BL21 (DE3) strain. The recombinant Tp0453 six-histidine-tagged protein was purified by the metal-chelate affinity chromatography. The resulting homogenous recombinant T. pallidum Tp0453 protein was used to reveal specific IgG antibodies in the serum of syphilis patients using a microarray technology. Results and conclusion. The use of the resulting recombinant protein enabled authors to reveal anti- T. pallidum antibodies in the blood serum of patients suffering from syphilis (primary, secondary, early and late latent syphilis). None of the uninfected controls had a significant reactivity to the recombinant Tp0453. These data allow to propose, that the recombinant protein Tp0453 show promise for laboratory diagnosis of syphilis. The introduction of Tp0453 antigen into the test systems for diagnosis of syphilis (ELISA, immunoblotting or microarray) increases the potential of serodiagnosis of this disease due to the broader range of the revealed antitreponemal antibodies.
Vestnik dermatologii i venerologii. 2013;89(6):73-79
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Hyperpigmentation problem and a new method for solving it
 
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Goal. To assess the efficacy and safety of Neoton serum and cream for the treatment of chloasma. Materials and methods. Ten women aged 25—60 suffering from chloasma received Neoton (Neoton cream in the morning and Neoton serum in the evening) for a month. The level of melanin in lesion foci was determined prior to and after the treatment using the Multi Skin Test Center MC 750 (Germany). Results. Prior to the treatment, the level of melanin ranged from 89 to 124 (for normal skin: from 6 to 40). The treatment with Neoton drugs resulted in a complete regression of eruptions in 30% of the women, substantial improvement in 60% of the patients and improvement in 10% of them. A reduction in the level of melanin ranging from 15 to 68 serves as an objective proof of the drug efficacy. Neither of the patients developed any adverse effects. Conclusion. Good tolerance and efficacy of Neoton serum and cream for the treatment of hyperpigmentation (chloasma) were demonstrated.
Vestnik dermatologii i venerologii. 2013;89(6):80-84
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Experience of treatment of psoriatic patients with monochromic ultraviolet light from excimer lamps in a combination with external drugs
 
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Goal. Comparative assessment of the efficacy of treating certain forms of psoriasis with monochromic ultraviolet light from excimer lamps in a combination with topical glucocorticosteroids or Kartalin cream. Materials and methods. As many as 22 patients (14 male and 8 female aged 25—62) with different clinical forms of psoriasis received a therapy with monochromic ultraviolet light from excimer lamps three times a week. The course of treatment with monochromic ultraviolet light from excimer lamps comprised 6—12 procedures. Topical glucocorticosteroids (GCS) or Kartalin cream were administered externally. Results. Complete regression of eruptions or essential clinical improvement was achieved against the background of treatment in 86% of the patients. At the same time, a clinically significant reduction of psoriatic symptoms was observed in most of the patients treated with Kartalin cream as soon as after the second or third phototherapy procedure while similar results were noted in the patients who received topical glucocorticosteroids only after the fourth procedure. Conclusion. Treatment of psoriatic patients with monochromic ultraviolet light from excimer lamps in a combination with Kartalin cream ensures a fast and positive clinical effect.
Vestnik dermatologii i venerologii. 2013;89(6):85-89
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Practical aspects of the management of patients with chronic hand eczema
 
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Urgency. High prevalence ot hand eczema stipulates the urgency ot studies ot significant factors ot the torpid course ot this disease, which is a result ot the sensitizing power ot the pathogenic biota in most cases. Goal. Optimization ot the therapy ot true hand eczema associated with chronic paronychias. Materials and methods. The tollow-up study comprised 30 patients suttering trom true hand eczema associated with chronic paronychias who underwent clinical and laboratory examinations with the determination ot the severity ot eczema, skin contamination and level ot specitic anti-Candida antibodies. Results. The authors revealed an evident clinical and laboratory etticacy ot the monotherapy with the Triderm cream aimed at the elimination ot paronychias and hand eczema.
Vestnik dermatologii i venerologii. 2013;89(6):90-93
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Recessive dystrophic epidermolysis bullosa: a case study
 
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The article presents a description of an inherited disease, recessive dystrophic epidermolysis bullosa, in a patient aged 19. The treatment with antibacterial, antiseptic, antianemic and wound-healing drugs, non-adhesive surgical dressings and lowintensive laser light substantially improved the patient’s condition.
Vestnik dermatologii i venerologii. 2013;89(6):94-99
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Zinc, its biological role and use in dermatology
 
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This literature review detines the biological role ot zinc in the human body, immune homeostasis and skin physiology as well as pathophysiology ot skin diseases. It describes the current range ot systemic and topical zinc preparations and their pharmacological characteristics. The review also describes skin diseases that may be treated with the use ot zinc preparations on a grounded basis, and discloses the clinical experience ot the use ot these drugs described in the world literature. It sets out certain recommendations tor using zinc preparations in clinical practice.
Vestnik dermatologii i venerologii. 2013;89(6):100-116
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Systemic antibiotics therapy of acne: certain controversies
 
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The article presents intormation about systemic antibiotics treatment ot acne. The authors discuss issues such as indications tor the administration ot antibiotics, drug selection and combination with external drugs.
Vestnik dermatologii i venerologii. 2013;89(6):117-121
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Current topical therapy of psoriatic patients suffering from scalp lesions
 
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Scalp lesions reduce the life quality of psoriatic patients. Goal. to assess the efficacy and safety of the topical therapy of psoriatic patients suffering from scalp lesions using a combination gel containing betamethasone and calcipotriol. Materials and methods. As many as 32 psoriatic patients suffering from scalp lesions received treatment. The clinical assessment was conducted using the PASI index. The Dermatology Life Quality Index (DLQI) was used to assess the patients’ life quality. Results. A reliable reduction in the PASI (by 69.9%) and DLQI (fivefold) indices was observed in most of the patients. No adverse effects or complications were observed as a result of the topical therapy of psoriatic patients with the gel containing betamethasone and calcipotriol. Conclusion. High efficacy and safety of the treatment method were observed.
Vestnik dermatologii i venerologii. 2013;89(6):122-127
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Antibiotic resistance of P. acnes in the treatment of acne. Ways for solving the problem
 
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The author describes the reasons and frequency of antibiotic resistance of P. acnes in acne patients. He reviews the strategy and methods for doctors to inhibit the prevalence of antibiotic resistance of P. acnes. The article discusses the important role of benzoyl peroxide and synergistic effect of the combination of adapalene and benzoyl peroxide in the finished form to overcome the antibiotic resistance of P. acnes and ensure the treatment efficacy.
Vestnik dermatologii i venerologii. 2013;89(6):128-131
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Seborrheic scalp dermatitis: current concepts of its etiology, pathogenesis and therapy
 
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The authors provide a review of current concepts of the epidemiology, etiology, pathogenesis and treatment principles for seborrheic scalp dermatitis. They also describe the results of multiple national and foreign studies confirming high clinical efficacy of ketoconazole 2% shampoo in the therapy of seborrheic dermatitis.
Vestnik dermatologii i venerologii. 2013;89(6):132-138
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A comparative, prospective, split-face, blind study of the efficacy of two botulinum toxin type A drugs (Disport® and Xeomin®) used to correct lateral periorbital wrinkles
 
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A prospective- blind- split-face- comparative study with evaluation of clinical efficacy- tolerability- and safety parameters of two botulinum toxin A (BTA) products (the one containing complexing proteins — Disport®- Ipsen- France/ abobotulinumtoxinA and the one free from complexing proteins — Xeomin®- Merz Pharma- Germany/incobotulinumtoxinA) used for correction of lateral periorbital wrinkles (crow's feet) was performed (at that- electromyographic evaluation of changes in functions of the orbicular muscle of eye was performed for the first time). Materials and Methods. Single injections of both BTA products with equal dose ratio of 3:1 (27 IU Disport® and 9 IU Xeomin®) were performed simultaneously to the right and left side half of the face (orbicular muscles of eye)- respectively- to each of 20 volunteers (women at the age of 40.9) with marked and moderate lateral periorbital wrinkles (2—3 degree according to 4-point Facial Wrinkle Scale/FWS). Clinical and electromyographic assessment was performed 2 weeks- 4 and 6 months after injections. Results. The effect of single dosing of Disport® and Xeomin® did not significantly differ at all assessment time points: both for primary efficacy criterion and for all secondary efficacy criteria; as well as for clinical evaluation by the investigator-subjects’ self-evaluation- and dynamics of M-response parameters for the orbicular muscle of eye. Good tolerability and safety were registered. Conclusion. Study results provided convincing evidence that Disport® and Xeomin® used in accordance with the proposed protocol had a comparable effect and duration of the effect on lateral periotbital wrinkles and the orbicular muscle of eye.
Vestnik dermatologii i venerologii. 2013;89(6):140-149
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Z.G. Stepanishcheva. On the 100th anniversary
 
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Vestnik dermatologii i venerologii. 2013;89(6):150-154
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