Assessment of the efficacy of antihistamine drugs in complex treatment of chronic itchingdermatoses


The authors give a review of current concepts of mechanisms of skin itching development for different types of chronic
dermatoses. The authors also present the results of a study aimed at assessing the efficacy of different 2nd generation
antihistamine drugs used for complex treatment of 83 patients aged 14-73 suffering from different chronic itching
dermatoses (atopic dermatitis, eczema, pruritus, chronic urticaria, progressing psoriasis, lichen acuminatus, contact
allergic dermatitis).
The authors conclude that Glencet (levocetirizine) used in a complex therapy of dermatoses accompanied with itching
can efficiently arrest both subjective itching sensations and objective clinical symptoms of the diseases as well as reliably
(р < 0.001) reduce the term of inpatient care by 4.8 ± 2.3 on average.
Glencet (levocetirizine) is a drug of choice among the 2nd generation antihistamine drugs used for treatment of chronic
skin diseases accompanied with itching.


  1. Соколовский Е.В. Кожный зуд. Акне. Урогенитальная хламидийная инфекция. СПб.: «СОТИС» 1988; 3-67.
  2. Торопина Г.Г., Иванов О.Л., Львов А.Н. Инновационные методы нейрофизиологического исследования механизмов зуда у больных атопическим дерматитом. Росс. журн. кожн. и венерич. бол, 2009; 4: 28-31.
  3. O'Neill J.L., Chan Y.H., Rapp S.R. Differences in itch characteristics between psoriasis and atopic dermatitis patients: results of a webbased questionnaire. Acta Derm Venereol. 2011 Apr 29 [Epub ahead of print].
  4. Devalia J.L., de Vos C., Hanotte F. et al. A randomized double-blind crossover comparison among cetirizine, levocetirizine and UCB 28557 on histamine-induced cutaneous responses in healthy adult volunteers. Allergy 2001; 56: 50-7.
  5. Salmun L.M. Antihistamines in late-phase clinical development for allergic disease. Expert Opin Invest Drugs 2002; 11: 259-73.
  6. Гребенченко Е.И., Гущин К., Феденко Е.С. Механизм кожного зуда при атопическом дерматите. Рос. аллергол. журн. 2009; 3: 3-11.
  7. Эбаноидзе Т., Беридзе Л., Твалиашвили Г. Нейроанатомические и нейрофизиологические аспекты зуда в лечении атопического дерматита. Аллергология и иммунология, 2010; 11: 2: 92-93.
  8. Свирщевская Е.В., Матушевская Е.В., Матушевская Ю.И. Патофизиология зуда при некоторых дерматозах. Росс. журн. кожн. венерич. болезней. 2009; 1: 19-23.
  9. Chen C. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem 2008; 15 (21): 2173-2191.
  10. Львов А.Н., Грундманн С., Штендер С. Хронический зуд: старые проблемы, новые решения. Росс. журн. кожн. венерич. болезней, 2010; 4: 7-12.
  11. Klimek L. Levocetirizine: from scientific evidence to a potent modern-day treatment of today's allergic patients. Drugs Today (Barc) 2009 (Mar); 45 (3): 213-225.

Copyright (c) 2011 Murashkin N.N., Gluzmin M.I., Materikin A.I., Murashkin N.N., Gluzmin M.I., Materi kin A.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies