Topical antibacterial medications for therapy of patient with acne

Cover Page

Cite item


Problems of acne pathogenesis are reviewed. Efficacy evaluation and safety use of 1% clindamycin solution at patient with acne are demonstrated.

About the authors

A. G. Pashinjan

The Russian National Research Medical University named after N.I. Pirogov

Author for correspondence.
Russian Federation

A. A. Shahnovich

FGBU “Polyclinic № 5” Office of the President of the Russian Federation

Russian Federation


  1. Dreno B. Recent data on epidemiology of acne. Ann Dermatol Venereol 2010; 137(2): 49-51. doi: 10.1016/S0151-9638(10)70024-7.
  2. Bhate K., Williams H.C. Epidemiology of acne vulgaris. Br J Dermatol 2013; 168(3): 474- 485. doi: 10.1111/bjd.12149.
  3. Dreno B., Layton A., Zouboulis C.C., Lopez-Estebaranz J.L., Zalewska-Janowska A., Bagat in E. et al. Adult female acne: a new paradigm. J Eur Acad Dermatol Venereol 2013; 27: 1063-70. doi: 10.1111/jdv.12061.
  4. Ghodsi S.Z., Orawa H., Zouboulis C.C. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol 2009; 129(9): 2136- 2141. doi: 10.1038/jid.2009.47.
  5. Makrantonaki E., Ganceviciene R., Zouboulis C. An update on the role of the sebaceous gland in the pathogenesis of acne. Dermatoendocrinol 2011; 3(1): 41-49. doi:10.4161.
  6. Kircik L.H. Advances in the Understanding of the Pathogenesis of Inflammatory Acne. J Drugs Dermatol 2016; 15(1): 7-10.
  7. Arora M.K., Yadav A., Saini V. Role of hormones in acne vulgaris. Clin Biochem. 2011; 44(13): 1035-40. doi: 10.1016.
  8. Cunha M.G., Fonseca FLA, Machado CDAS. Androgenic Hormone Profile of Adult Women with Acne. Dermatology 2013; 226(2): 167-71. doi: 10.1159/000347196.
  9. Schmidt T.H., Shinkai K. Evidence-based approach to cutaneous hyperandrogenism in women. J Am Acad Dermatol 2015; 73(4): 672-90. doi: 10.1016.
  10. Del Prete M., Mauriello M.C., Faggiano A., Di Somma C., Monfrecola G., Fabbrocini G., Co-lao A. Insulin resistance and acne: a new risk factor for men? Endocrine 2012; 42: 555-60. doi: 10.1007/s12020-012-9647-6.
  11. Pace J.L. Acne - a potential skin marker of internal disease. Clin Dermatol 2015; 33(5): 572-8. doi: 10.1016/j.clindermatol.2015.05.010.
  12. Perry A., Lambert P. Propionibacterium acnes: Infection beyond the skin. Expert Review of Anti-infective Therapy 2011; 9 (12): 1149-56. doi: 10.1586/eri.11.137.
  13. Gomes PdeS., Fernandes M.H. Defensins in the oral cavity: distribution and biological role. J Oral Pathol Med 2010; 39(1): 1-9. doi: 10.1111/j.1600-0714.2009.00832.
  14. Niyonsaba F., Nagaoka I., Ogawa H., Human defensins and cathelicidins in the skin: beyond direct antimicrobial properties. Crit. Rev. Immunol 2006; 26(6): 545-76.
  15. Ozlu E., Karadag A.S., Ozkanli S., Oguztuzun S., Kilic M., Zemheri E et al. Comparison of TLR-2, TLR-4, and antimicrobial peptide levels in different lesions of acne vulgaris. Cutan Ocul Toxicol 2015; (23):1-10. doi: 10.3109/15569527.2015.1120742.
  16. Kim M.K., Choi S.Y., Byun H.J., Huh C.H., Park K.C., Patel R.A. et al. Comparison of sebum secretion, skin type, pH in humans with and without acne. Arch Dermatol 2006; 298(3):113-9.
  17. Schauber J., Gallo R.L. Expanding the roles of antimicrobial peptides in skin: alarming and arming keratinocytes. J Invest Dermatol 2007; 127(3): 510-2.
  18. Pashinyan A.G. Modern methods of therapy of an acne. Medical Council 2010;(5-6): 61-62 [Пашинян А.Г. Современные методы терапии акне. Медицинский Совет 2010; (5-6): 61-62].
  19. Zaenglein A.L., Pathy A.L., Schlosser B.J., Alikhan A., Baldwin H.E., Berson D.S. et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol 2016; 74(5): 945-73. doi: 10.1016/j.jaad.2015.12.037.
  20. Savage L.J., Layton A.M. Treating acne vulgaris: systemic, local and combination therapy. Expert Rev Clin Pharmacol 2010; 13: 563- 580. doi: 10.1586/ecp.10.27.
  21. Kubanova A.A., Kubanov A.A., Samzov V.A., Araviiskaia E.A. Federalnyie klinicheskie rekomendatsii po vedeniyu bolnyih akne. Rossiyskoe obschestvo dermatovenerologov i kosmetologov. M., 2016; 9-27. [Кубанова А.А., Кубанов А.А., Самцов А.В., Аравийская Е.Р. Федеральные клинические рекомендации по ведению больных акне. Российское общество дерматовенерологов и косметологов. М., 2016; 9-27].
  22. Kanliff V.Dzh. Akne. V kn: Katsambas A. D., Lotti T. M. (red.) Evropeyskoye rukovodstvo po lecheniyu dermatologicheskikh zabolevaniy: Per. s angl. M.: MEDpress-inform. 2008; 19-24. [Канлифф В.Дж. Акне. В кн: Кацамбас А. Д., Лотти Т. М. (ред.) Европейское руководство по лечению дерматологических заболеваний: Пер. с англ. М: МЕДпресс-информ, 2008; 19-24.]
  23. Del Rosso J.Q., Schmidt N.F. A review of the antiinflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis. 2010; 85(1):15-24.
  24. Alirezai M., Gerlach B., Horvath A., Forsea D., Bri-antais P., Guyomar M. Results of a randomised, multicentre study comparing a new water-based gel of clindamycin 1% versus clindamycin 1% topical solution in the treatment of acne vulgaris. Eur J Dermatol 2005; 15(4): 274-8.
  25. Guay D.R. Topical clindamycin in the management of acne vulgaris. Expert Opin Pharmaco-ther 2007; 8(15): 2625-64.
  26. Monakhov S.A. Clindamycinsolution (1%) in thetherapy of acne. Klin Dermatol Venerol 2012; (5): 85-88 [Монахов С.А. Раствор клиндамицина (1%) в терапии акне. Клин дерматол и венерол 2012; (5): 85-88].

Copyright (c) 2017 Pashinjan A.G., Shahnovich A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 60448 от 30.12.2014.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies