Volf’s isotopic response

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The term of “isotopic response” was offered by R. Wolf and co-authors in 1995 and means the development of the new dermatosis at the place of already existing initial one, which has already regressed and is not directly referred to the first one. The article describes the essence of the phenomena and most important clinical cases. Such pathogenic mechanisms as viral, immunologic, vascular, neurogenic theory are being discussed, as well as the immunocompromised site concept. The commonality and the difference of the isotopic response and of the isomorphic Kobner’s phenomenon are being analyzed. Two clinical cases are provided.

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Изотопический ответ Вольфа

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  1. Wyburn-Mason R. Malignant change arising in tissues affected by herpes. British Medical Journal 1955; 2: 1106-1109.
  2. Wolf R, Wolf D. Tinea in a site of healed herpes zoster. Int J Dermatol 1985; 24: 539.
  3. Wolf R, Brenner S, Ruocco V et al. Isotopic response. Int J Dermatol 1995; 34: 341-348.
  4. Tuzun Y, Iscimen A, Göksügür N. et al. Wolf's isotopic response: Trichophyton rubrum folliculitis appearing on a herpes zoster scar. Int J Dermatol 2000; 39(10): 766-8.
  5. Sharma RC, Sharma NL, Mahajan V. et al. Wolf's isotopic response: herpes simplex appearing on scrofuloderma scar. Int J Dermatol 2003; 42(8): 664-6.
  6. Abraham Z, Feuerman EJ, Schafer I. et al. Disseminated granuloma annulare following erythema multiforme minor. Australasian J Dermatol 2000; 41(4): 238-41.
  7. Karakab M, Durdu M, Ozbilen A. Molluscum contagiosum on region of burned skin: Wolf’s isotopic response. JEADV 2006; 20(8): 1014-1016.
  8. Fernandez-Redondo V, Amrouni B, Varela E. et al. Granulomatous folliculitis at sites of herpes zoster scars: Wolf's isotopic response. JEADV 2002; 16(6): 628-30.
  9. Lutz ME, Perniciaro C, Lim KK. Zosteriform lichen planus without evidence of herpes simplex virus or varicella-zoster virus by polymerase chain reaction. Report of two cases. Acta Dermato-Venereologica 1997; 77: 491-492.
  10. Perry D, Fazel N. Zosteriform lichen planus. Dermatology Online Journal 2006; 12(5): 3.
  11. Ghorpade A. Wolf's isotopic response--lichen planus at the site of healed herpes zoster in an Indian woman. Int J Dermatol 2010; 49(2): 234-5.
  12. Ghosh SK, Bandyopadhyay D, Chatterjee G. et al. Wolf's isotopic response: large annular polycyclic lichen planus occurring on healed lesions of dermatophytosis. JEADV 2009; 23(3): 355-6.
  13. Lopez N, Alcaraz I, Cid-Manas J. et al. Wolf's isotopic response: zosteriform morphea appearing at the site of healed herpes zoster in a HIV patient. JEADV 2009; 23(1): 90-2.
  14. Forschner A, Metzler G, Rassner G. et al. Morphea with features of lichen sclerosus et atrophicus at the site of a herpes zoster scar: another case of an isotopic response. Int J Dermatol 2005; 44(6): 524-5.
  15. Lee HW, Lee DK, Rhee DY et al. Erythema annulare centrifugum following herpes zoster infection: Wolf's isotopic response? BJD 2005; 153(6): 1241-3.
  16. He C, Xu H, Xiao T et al. Localized linear Ig A dermatosis induced by UV light treatment for herpes zoster. Int J Dermatol 2007; 46: 500-502.
  17. Kim MB, Jwa SW, Ko HC et al. A case of secondary cutaneous mucinosis following herpes zoster: Wolf's isotopic response. Int J Dermatol 2009; 48(2): 212-4.
  18. Sanli HE, Ko^yigit P, Arica E et al. Granuloma annulare on herpes zoster scars in a Hodgkin's disease patient following autologous peripheral stem cell transplantation. JEADV 2006; 20(3): 314-7.
  19. Watanabe D, Kuhara T, Ishida N. et al. Sarcoid tissue reaction on herpes zoster scars in a myelodysplastic syndrome patient: Wolf's isotopic response. JEADV 2009; 23(4): 475-7.
  20. Sezer E, Koseoglu RD, Filiz N. Wolf's isotopic response: rosacea appearing at the site of healed herpes zoster. Australasian J Dermatol 2006; 47(3): 189 91.
  21. Ruocco E. Genital warts at the site of healed herpes progenitalis: the isotopic response. Int J Dermatol 2000; 39: 705-706.
  22. Ruocco E, Tripodi Cutri F, Baroni A. Bowenoid papulosis at the site of prior herpes genitalis. SKINmed 2004; 3: 347-349.
  23. Ruocco V, Brunetti G, Puca RV et al. The immunocompromised district: a unifying concept for lymphoedematous, herpes-infected and otherwise damaged sites. JEADV 2009; 23(12): 1364-73.
  24. Chuan-I Liu, Che-Hao Hsu Leukaemia cutis at the site of striae distensae: an isotopic response? Acta Dermato-Venereologica 2010; 90(4): 422-423.
  25. Wolf R, Wolf D, Ruocco E et al. Wolf's isotopic response. Clin Dermatol 2011; 29(2): 237-40.
  26. Sanchez-Salas MP. Appearance of comedones at the site of healed herpes zoster: Wolf's isotopic response. Int J Dermatol 2011; 50(5): 633-4.
  27. Ruocco V, Ruocco E, Ghersetich I et al. Isotopic response after herpesvirus infection: an update. JAAD 2002; 46(1): 90-4.
  28. Ruocco E, Baroni A, Cutri FT et al. Granuloma annulare in a site of healed herpes zoster: Wolf's isotopic response. JEADV2003; 17(6): 686-688.
  29. Schena D, Barba A, Chieregato C. Granulomatous folliculitis as a manifestation of postherpetic isotopic response. JEADV 2001; 15: 473-5.
  30. Gibney MD, Nahass GT, Leonardi CL. Cutaneous reactions following herpes zoster infections: report of three cases and a review of the literature. BJD 1996; 134: 504-9.
  31. Ruocco V, Ruocco E, Brunetti G et al. Achilles heel in dermatology. JEADV 2010; 24: 1119-1121.
  32. Wolf R, Lotti T, Ruocco V. Isomorphic versus isotopic response: data and hypotheses. JEADV 2003; 17: 123-125.

Copyright (c) 2012 BOROVIKOV Y.E., BUKIN Y.K.

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