Using immune response modifiers for urogenital clamidiosis. Mathematic simulation and forecast of clamidiosis epidemiological process


There was an analysis of the role immune response modifiers (by the example of Cycloferon) play as a part of treatment schemes of urogenital clamidiosis from the point of view of public health. A math model of the chlamydia infection dynamics in a hypothetic cohort of women running a high risk of infection (commercial sex workers) and their clients was used for the analysis. The data of the study of commercial sex workers from ten regions of the Russian Federation as well as data published on the Cycloferon treatment efficacy were used for model calibration. The resulting data confirm that making immune response modifiers a part of the urogenital clamidiosis treatment regimen decreases the prevalence of the disease in the population by 6-30%. The strategy aimed at making the drug a part of the treatment regimen for the risk group patients seems to be most efficient.


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