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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">10515</article-id><article-id pub-id-type="doi">10.25208/vdv10515</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASE REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЕ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Valproic acid induced Stevens–Johnson syndrome</article-title><trans-title-group xml:lang="ru"><trans-title>Синдром Стивенса–Джонсона, индуцированный приемом вальпроевой кислоты</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8874-3663</contrib-id><contrib-id contrib-id-type="spin">5096-6710</contrib-id><name-alternatives><name xml:lang="en"><surname>Somov</surname><given-names>Dmitry V.</given-names></name><name xml:lang="ru"><surname>Сомов</surname><given-names>Дмитрий Вадимович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant Lecturer</p></bio><bio xml:lang="ru"><p>ассистент</p></bio><email>somovmd@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7142-2484</contrib-id><name-alternatives><name xml:lang="en"><surname>Chernyaeva</surname><given-names>Alina Yu.</given-names></name><name xml:lang="ru"><surname>Черняева</surname><given-names>Алина Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>alinaache23@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3754-5333</contrib-id><name-alternatives><name xml:lang="en"><surname>Mazus</surname><given-names>Veronika A.</given-names></name><name xml:lang="ru"><surname>Мазус</surname><given-names>Вероника Алексеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>veroni2001@list.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6312-0291</contrib-id><name-alternatives><name xml:lang="en"><surname>Nurieva</surname><given-names>Lyaman T.</given-names></name><name xml:lang="ru"><surname>Нуриева</surname><given-names>Ляман Тарлан кызы</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>lemi_enigma@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7374-0374</contrib-id><contrib-id contrib-id-type="spin">3058-6092</contrib-id><name-alternatives><name xml:lang="en"><surname>Bobrov</surname><given-names>Maxim A.</given-names></name><name xml:lang="ru"><surname>Бобров</surname><given-names>Максим Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>m.a.bobrov@yandex.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5610-4819</contrib-id><contrib-id contrib-id-type="spin">2891-6763</contrib-id><name-alternatives><name xml:lang="en"><surname>Anichkov</surname><given-names>Dmitry A.</given-names></name><name xml:lang="ru"><surname>Аничков</surname><given-names>Дмитрий Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>d.anichkov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian National Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет имени Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov City Clinical Hospital No. 1</institution></aff><aff><institution xml:lang="ru">Государственная клиническая больница № 1 им. Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">N.I. Pirogov City Clinical Hospital No. 1</institution></aff><aff><institution xml:lang="ru">Государственная клиническая больница №1 им. Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Moscow Scientific and Practical Center of Dermatology and Venerology and Cosmetology of the Department of Health</institution></aff><aff><institution xml:lang="ru">Московский научно-практический Центр дерматовенерологии и косметологии Департамента здравоохранения города Москвы</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-06-05" publication-format="electronic"><day>05</day><month>06</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-07-11" publication-format="electronic"><day>11</day><month>07</month><year>2024</year></pub-date><volume>100</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>74</fpage><lpage>79</lpage><history><date date-type="received" iso-8601-date="2023-05-22"><day>22</day><month>05</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2024-05-21"><day>21</day><month>05</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Somov D.V., Chernyaeva A.Y., Mazus V.A., Nurieva L.T., Bobrov M.A., Anichkov D.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Сомов Д.В., Черняева А.Ю., Мазус В.А., Нуриева Л.Т., Бобров М.А., Аничков Д.А.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Somov D.V., Chernyaeva A.Y., Mazus V.A., Nurieva L.T., Bobrov M.A., Anichkov D.A.</copyright-holder><copyright-holder xml:lang="ru">Сомов Д.В., Черняева А.Ю., Мазус В.А., Нуриева Л.Т., Бобров М.А., Аничков Д.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/10515">https://vestnikdv.ru/jour/article/view/10515</self-uri><abstract xml:lang="en"><p>A 27-year-old transgender female at the stage of gender transition with bipolar disorder for which she received valproic acid developed multiple petechial rashes on the chest, upper and lower extremities, local erythematous lesions with forming blisters, large-platelet peeling on the face, neck, chest and inguinal area, erosion on the oral mucosa. She was diagnosed with drug eruption, Stevens–Johnson syndrome. The diagnosis was verified on the basis of complaints, medical history, clinical picture, laboratory findings. Treatment included valproic acid withdrawal, dexamethasone, infusion therapy, vancomycin, cyclosporine A. Against the background of the therapy, skin condition was improved: there was the epithelization of ulcerative defects and the absence of new elements.</p></abstract><trans-abstract xml:lang="ru"><p>У пациентки М. 27 лет в стадии трансгендерного (трансфеминного) перехода, с диагностированным биполярным аффективным расстройством, по поводу которого проводилась терапия препаратом вальпроевой кислоты, появились множественные петехиальные высыпания на коже туловища, верхних и нижних конечностей, локализованные эритемы с формирующимися пузырями, крупнопластинчатое шелушение на коже лица, шеи, груди и паховой области, эрозии на слизистой оболочке полости рта и красной каймы губ. На основании анамнеза, жалоб, клинической картины и лабораторных данных поставлен диагноз «лекарственно-индуцированная кожная реакция: синдром Стивенса–Джонсона». Проводимое лечение: отмена препарата вальпроевой кислоты, дексаметазон, инфузионная терапия, циклоспорин А. На фоне проводимой терапии отмечается улучшение состояния кожного покрова: отсутствие новых элементов и эпителизация эрозий.</p></trans-abstract><kwd-group xml:lang="en"><kwd>clinical case</kwd><kwd>Stevens–Johnson syndrome</kwd><kwd>valproic acid</kwd><kwd>toxicoderma</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>клинический случай</kwd><kwd>синдром Стивенса–Джонсона</kwd><kwd>вальпроевая кислота</kwd><kwd>токсикодермия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Кубанов А.А., Горланов И.А., Самцов А.В., Хайрутдинов В.Р. Синдром Стивенса–Джонсона. Клинические рекомендации Российского общества дерматовенерологов и косметологов. М.; 2020. [Kubanov AA, Gorlanov IA, Samcov AV, Khairutdinov VR. Stevens-Johnson syndrome. Clinical guidelines of Russian society of dermatovenereologists and cosmetologists. Moscow; 2020. (In Russ.)]</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Дюбкова Т.П., Жерносек В.Ф. Интенсивная терапия синдрома Стивенса–Джонсона — токсического эпидермального некролиза у детей. Экстренная медицина. 2013;3(7):92–108. [Dyubkova TP, Zhernosek VF. Intensive care of Stevens–Jonson syndrome — toxic epidermal necrolysis in children. Emergency medicine. 2013;3(7):92–108. (In Russ.)]</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>McNamara JO. Pharmacotherapy of the epilepsies. Brunton LL, Lazo JS, Parker KL, Goodman &amp; Gilman’s the pharmacological basis of therapeutics. 11th ed. N.Y.: McGraw Hill; 2006. P. 521–548.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Rashid M, Kashyap A, Undela K. Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. Int J Dermatol. 2019;58(9):1014–1022. doi: 10.1111/ijd.14411</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Kumar PN, Kumar SK. Stevens–Johnson syndrome induced by sodium valproate. Indian J Psychiatry. 2004;46(3):269–270.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Baba M, Karakas M, Aksungur VL, Homan S, Yücel A, Acar MA, et al. The anticonvulsant hypersensitivity syndrome. J Eur Acad Dermatol Venereol. 2003;17:399–401. doi: 10.1046/j.1468-3083.2003.00750.x</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Charlton AA, Harris W, Fan K, Mouton E, Jackson S, Cooper A. Toxic epidermal necrolysis and Stephen-Johnson syndrome: a comprehensive review. Adv Wound Care (New Rochelle). 2020;9(7):426–439. doi: 10.1089/wound.2019.0977</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Hu CH, Chang NJ, Liu EW, Chuang SS, Chung WH, Yang JY. SCORTEN and impaired renal function related to mortality of toxic epidermal necrolysis syndrome patients in the Asian population. J Eur Acad Dermatol Venereol. 2013;27(5):628–633. doi: 10.1111/j.1468-3083.2012.04502.x</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Torres-Navarro I, Briz-Redon A, Botella-Estrada R. Accuracy of SCORTEN to predict the prognosis of Stevens-Johnson syn-drome/Toxic Epidermal Necrolysis: A systematic review and meta-analysis. J Eur Acad Dermatol Venereol. 2020;34(9):2066–2077. doi: 10.1111/jdv.16137</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Imahara SD, Holmes JH, Heimbach DM, Engrav LE, Honari S, Klein MB, et al. SCORTEN Overestimates Mortality in the Setting of a Standardized Treatment Protocol. J Burn Care Res. 2006;27(3):270–275. doi: 10.1097/01.BCR.0000216532.71360.9B</mixed-citation></ref></ref-list></back></article>
