Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov113810.25208/vdv1138-2020-96-5-47-52Research ArticleTreatment of palpebral melanocytic nevi with a dual-wavelengths copper vapor laserPonomarevI. V.luklalukla@ya.ruhttps://orcid.org/0000-0002-3345-3482AndrusenkoYu. N.<p>Surgeon, Oncodermatologist, Head of the Department,</p>
<p>Constitution sq., 26, Kharkov, 61000</p>ure.doc@rambler.ruTopchiySergeysergtopchiy@mail.ruhttps://orcid.org/0000-0001-6540-9235ShakinaLudmila221050@mail.ruhttps://orcid.org/0000-0002-3811-4367P.N. Lebedev Physical Institute of the Russian Academy of SciencesMedical Center “Health Institute”National Medical Research Center of Children's Health1412202096547521905202022072020Copyright © 2020, Ponomarev I.V., Andrusenko Y.N., Topchiy S., Shakina L.2020<p>Acquired melanocytic nevi in aesthetically significant areas, especially palpebral nevi (PN), are becoming a frequent reason for patients to seek dermatologists. Surgical methods for removal of PN are reported to be associated with the risk of such side effects as scars and loss of eyelashes.</p>
<p><strong>Aim of the study.</strong> To evaluate the efficacy of the removal of PN on the eyelid area with dual-wavelength radiation of a copper vapor laser (CVL).</p>
<p><strong>Patients and methods.</strong> Laser removal of medium and large-sized PN (up to 10 mm) was performed in three fair-skin female patients. The procedures were carried out at an average CVL radiation power of 0.60.8 W, at a 3:2 ratio of radiation powers at wavelengths of 511 nm and 578 nm, exposure duration 0.3 s, light spot diameter 1 mm. The treatment was carried out during one session.</p>
<p><strong>Results.</strong> Removal of PN with dual-wavelength CVL radiation allowed achieving a significant lightening and reduction of the involved area, without scars. The skin healing after the procedure lasted 2 weeks.</p>
<p><strong>Conclusion.</strong> The high efficacy of the PN removing in the eyelid area using the dual-wavelength CVL radiation allows the introduction of this approach into dermatologists and cosmetologists clinical practice.</p>intradermal melanocytic nevuseyelid nevuscopper vapor laserlaser treatmentperiorbital laser treatmentмеланоцитарный невусневус веклазер на парах медилазерное лечение в периорбитальной области[Stark MS, Tan JM, Tom L, et al. Whole-Exome Sequencing of Acquired Nevi Identifies Mechanisms for Development and Maintenance of Benign Neoplasms. J Invest Dermatol. 2018;138(7):1636–1644. doi: 10.1016/j.jid.2018.02.012][Iyevleva AG, Imyanitov EN. Cytotoxic and targeted therapy for hereditary cancers. Hered Cancer Clin Pract. 2016;14(1):17. doi: 10.1186/s13053-016-0057-2][Gundalli S, Kadadavar S, Singhania S, Kolekar R. Histopathological spectrum of benign melanocytic nevi — our experience in a tertiary care centre. Our Dermatol Online. 2016;7(1):21–25.][Alves RV, Brandão FH, Aquino JE, Carvalho MR, Giancoli SM, Younes EA. Intradermal melanocytic nevus of the external auditory canal. Braz J Otorhinolaryngol. 2005;71(1):104–106. doi: 10.1016/s1808-8694(15)31295-7][Yus ES, del Cerro M, Simón RS, et al. Unna's and Miescher's Nevi: Two Different Types of Intradermal Nevus: Hypothesis Concerning Their Histogenesis, The American Journal of Dermatopathology. 2007;29(2):141–151. doi: 10.1097/DAD.0b013e31803325b2][Яровой А.А., Шацких А.В., Булгакова Е.С. & Кривовяз О.С. Результаты хирургического лечения меланоцитарных невусов кожи век. Российский офтальмологический журнал. 2014;7(1):53–57. [Yarovoy AA, Shatskikh AV, Bulgakova ES, & Krivovyaz OS. Rezul'taty khirurgicheskogo lecheniya melanotsitarnykh nevusov kozhi vek. Rossiyskiy oftal'mologicheskiy zhurnal. 2014;7(1):53–57 (In Russ.)]][Chopra K, Calva D, Sosin M, et al. A comprehensive examination of topographic thickness of skin in the human face. Aesthet Surg J. 2015;35(8):1007–1013. doi: 10.1093/asj/sjv079][Дубенский В.В., Дубенский В.В. & Гармонов А.А. Новообразования кожи в практике дерматовенеролога. Вопросы эпидемиологии, этиопатогенеза и диагностики. Вестник дерматологии и венерологии. 2009;1:18–26. [Dubenskiy VV, Dubenskiy VV, & Garmonov AA. Novoobrazovaniya kozhi v praktike dermatovenerologa. Voprosy epidemiologii, etiopatogeneza i diagnostiki. Vestnik dermatologii i venerologii. 2009;1:18–26 (In Russ.)]][Parver DL, Dreher RJ, Kohanim S, et al. Ocular injury after laser hair reduction treatment to the eyebrow. Arch Ophthalmol. 2012;130(10):1330–1334. doi: 10.1001/archophthalmol.2012.1988][Huang A, Phillips A, Adar T, Hui A. Ocular Injury in Cosmetic Laser Treatments of the Face. J Clin Aesthet Dermatol. 2018;11(2):15–18.][Ключарева С.В., Пономарев И.В., Топчий С.Б. и др. Лечение базальноклеточного рака кожи в периорбитальной области импульсным лазером на парах меди. Вестник дерматологии и венерологии. 2018;94(6):15–21. [Klyuchareva SV, Ponomarev IV, Topchiy SB, et al. Treatment of basal cell cancer in the periorbital area using a pulsed copper vapour laser. Vestnik dermatologii i venerologii. 2018;94(6):15–21 (In Russ.)]][Siskind V, Darlington S, Green L, Green A. Evolution of melanocytic nevi on the faces and necks of adolescents: a 4 y longitudinal study. J Invest Dermatol. 2002;118(3):500–504. doi: 10.1046/j.0022-202x.2001.01685.x][Lee SE, Choi JY, Hong KT, Lee KR. Treatment of acquired and small congenital melanocytic nevi with combined Er: YAG laser and long-pulsed alexandrite laser in Asian skin. Dermatol Surg. 2015;41(4):473–480. doi: 10.1097/DSS.0000000000000288][Zhu L, Jia Y, Wang X. Treatment of eyelid nevus with CO2 laser: A double-edged sword. J Dermatolog Treat. 2015;26(3):257–258. doi: 10.3109/09546634.2014.945894][Raulin C, Schönermark MP, Greve B, Werner S. Q-switched ruby laser treatment of tattoos and benign pigmented skin lesions: a critical review. Ann Plast Surg. С 1998;41(5):555–565. doi: 10.1097/00000637-199811000-00018][Angermair J, Dettmar P, Linsenmann R, Nolte D. Laser therapy of a dermal nevus in the esthetic zone of the nasal tip: A case report and comprehensive literature review. J Cosmet Laser Ther. 2015;17(6):296–300. doi: 10.3109/14764172.2015.1027229][Kim YJ, Whang KU, Choi WB, et al. Efficacy and safety of 1,064 nm Q-switched Nd:YAG laser treatment for removing melanocytic nevi. Ann Dermatol. 2012;24(2):162–167. doi: 10.5021/ad.2012.24.2.162][Карымов О.Н., Калашникова С.А., Соловьева И.О., Полякова Л.В. Гистотопографические особенности строения кожи лица. Журнал анатомии и гистопатологии. 2017;6(1):29–32. [Karymov ON, Kalashnikova SA, Soloviev IO, Polyakova LV. Histotopographic Features of Facial Skin Structure. Journal Anatomy and Histopathology. 2017;6(1):29–32 (In Russ.)]][Шакина Л.Д., Сорвачева Т.Н., Юхтина Н.В., Рылеева И.В., Шакин С.А. Становление эндокринной регуляции и парного гомеостаза у детей и подростков. Вопросы современной педиатрии. 2005;4(1):58–61. [Shakina LD, Sorvacheva TN, Yukhtina NV, Ryleeva IV, Shakin SA. Formation of endocrine regulation of immune homeostasis in children and adolescents. Current Pediatrics" ("Voprosy Sovremennoi Pediatrii" 2005;4(1):58–61 (In Russ.)]][Einspahr JG, Thomas TL, Saboda K, et al. Expression of vascular endothelial growth factor in early cutaneous melanocytic lesion progression. Cancer. 2007;110(11):2519–2527. doi: 10.1002/cncr.23076][Regazzetti C, De Donatis GM, Ghorbel HH, et al. Endothelial Cells Promote Pigmentation through Endothelin Receptor B Activation. J Invest Dermatol. 2015;135(12):3096–3104. doi: 10.1038/jid.2015.332][Klyuchareva SV, Ponomarev IV, Pushkareva AE. Numerical Modeling and Clinical Evaluation of Pulsed Dye Laser and Copper Vapor Laser in Skin Vascular Lesions Treatment. J Lasers Med Sci. 2019;10(1):44–49. doi: 10.15171/jlms.2019.07]