Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov114110.25208/vdv1141CLINICAL PRACTICE GUIDELINESКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИResearch ArticleSkin manifestations of a new coronovirus infection COVID-19 caused by SARS-CoV-2Кожные проявления при новой коронавирусной инфекции COVID-19, вызванной SARS-CoV-2https://orcid.org/0000-0001-9248-83034311-2475KhryaninAleksey A.ХрянинАлексей Алексеевич
Russian Federation

Doctor of Medical Sciences, Professor of the Department of Dermatovenereology and Cosmetology of the Novosibirsk State Medical University under the Ministry of Health of Russian Federation, Vice President of the Association of Obstetricians-Gynecologists and Dermatovenereologists

д.м.н., профессор кафедры дерматовенерологии и косметологии ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России, вице-президент РОО «Ассоциация акушеров-гинекологов и дерматовенерологов»

khryanin@mail.ruhttps://orcid.org/0000-0001-8243-247X9799-2755SturovViktor G.СтуровВиктор Геннадьевич
Russian Federation

MD, Professor of the Institute of Medicine and Psychology Named After V. Zelman, in the Novosibirsk National Research State University under the Ministry of Science and Higher Education of Russian Federation

д.м.н., профессор Института медицины и психологии В. Зельмана ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет» Миннауки и ВО России

sturov@mail.ruhttps://orcid.org/0000-0003-0400-10118777-9748NadeevAlexander P.НадеевАлександр Петрович
Russian Federation

MD, Professor, Head at the Department of Pathological Anatomy in the Novosibirsk State Medical University under the Ministry of Health of Russian Federation

д.м.н., профессор, заведующий кафедрой патологической анатомии ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России

nadeevngma@mail.ruhttps://orcid.org/0000-0003-4671-7288BocharovaValentina К.БочароваВалентина Константиновна
Russian Federation

6th-year student of the Pediatric Faculty of the Novosibirsk State Medical University under the Ministry of Health of Russian Federation

студентка 6-го курса педиатрического факультета ФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава России

valuha-95@yandex.ruNovosibirsk State Medical UniversityФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииAssociation Obstetricians-Gynecologists and DermatovenerologistsРОО «Ассоциация акушеров-гинекологов и дерматовенерологов»V. Zelman Institute of medicine and psychology, Novosibirsk National Research State UniversityФГАОУ ВО «Новосибирский национальный исследовательский государственный университет» Миннауки и ВО России, Институт медицины и психологии В. Зельмана2909202096353622805202026062020Copyright ©; 2020, Khryanin A.A., Sturov V.G., Nadeev A.P., Bocharova V.К.Copyright ©; 2020, Хрянин А.А., Стуров В.Г., Надеев А.П., Бочарова В.К.2020Khryanin A.A., Sturov V.G., Nadeev A.P., Bocharova V.К.Хрянин А.А., Стуров В.Г., Надеев А.П., Бочарова В.К.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/1141

The review is devoted to the skin manifestations of new coronovirus infection (SARS-CoV-2), information about which is constantly updated. However, this information has not been systematized yet. The purpose of this review is to analyze the dermatological manifestations of a new coronavirus infection. On average, 12.5—20.4% of patients with confirmed COVID-19 have developed skin manifestations. The question of whether the skin symptoms are a secondary consequence of a respiratory infection or a primary infection of the skin itself remains open at the moment. The possible mechanisms of development of skin lesions and the role of diseases of complement system and blood hypercoagulation in the pathogenesis of the disease are discussed in the article. The review also provides descriptive and clinical examples of skin manifestations in COVID-19. Since COVID-19 tends to be asymptomatic within 14 days, skin manifestations can be an indicator of infection, which leads to the timely diagnosis. In addition, doctors' awareness about skin symptoms associated with COVID-19 infection plays a big role in preventing misdiagnosis of the disease. The authors cite their own clinical сase of a patient with COVID-19 and associated skin angiitis.

Обзор посвящен кожным проявлениям при новой коронавирусной инфекции, информация о которых непрерывно обновляется и дополняется. Однако до сих пор имеющиеся данные не были систематизированы. Целью данного обзора является анализ дерматологических проявлений при новой коронавирусной инфекции. В среднем у 12,5—20,4% пациентов с подтвержденным COVID-19 развились кожные проявления. Вопрос о том, являются ли кожные симптомы вторичным следствием респираторной инфекции или первичной инфекцией самой кожи, на данный момент остается открытым. Обсуждаются вероятные механизмы развития поражений кожи и роли болезней системы комплемента и состояния гиперкоагуляции крови в патогенезе их развития. В обзоре также приводятся клинические примеры вовлечения кожных покровов в инфекционный процесс при COVID-19. Поскольку COVID-19 имеет тенденцию к бессимптомному течению на протяжении 14 дней после заражения, кожные проявления могут служить индикатором инфекции, способствуя своевременной диагностике. Кроме того, осведомленность врачей о кожных симптомах, связанных с инфекцией COVID-19, имеет решающее значение для предотвращения неправильного диагноза заболевания. Авторы приводят собственное клиническое наблюдение пациентки с COVID-19 и ассоциированным ангиитом кожи.

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