Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov115710.25208/vdv1157DRUG TREATMENT IN DERMATOVENEROLOGYФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИReview ArticleNew technologies in topical acne therapyНовые технологии в комбинированной топической терапии акнеSamtsovAlexey V.СамцовАлексей Викторович
Russian Federation

Dr. Sci. (Med.), Prof., Departmental Head, Department of Skin and Venereal Diseases, S.M. Kirov Military Medical Academy, Ministry of Defence of the Russian Federation

д.м.н., профессор, заведующий кафедрой кожных и венерических болезней Военно-медицинской академии им. С.М. Кирова Министерства обороны Российской Федерации

avsamtsov@mail.ruFederal state budgetary educational institution of higher military education “Military Medical Academy named after S.M. Kirov” of the Russian Ministry of DefenseФГБВОУ ВО «Военно-медицинская академия им. С. М. Кирова» Министерства обороны Российской Федерации2909202096375790408202014082020Copyright ©; 2020, Samtsov A.V.Copyright ©; 2020, Самцов А.В.2020Samtsov A.V.Самцов А.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/1157

The article is of an overview nature, it outlines the current understanding of the pathophysiology of acne, provides data on the role of retinoids in the treatment of dermatosis, discusses the advantages of combination therapy and new technologies in the treatment of acne.

Статья носит обзорный характер, в ней излагаются современные представления о патофизиологии акне, приводятся данные о роли ретиноидов в терапии дерматоза, рассматриваются преимущества комбинированной терапии и новые технологии в наружном лечении акне.

acneadapaleneclindamycinmicrospheresакнеадапаленклиндамицинмикросферыZaenglein А., Pathy А., Schlosser В. et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. http://dx.doi.org/10.1016/j.jaad.2015.12.037.Dreno B., Gollnick H.P., Kang S., Thiboutot D., Bettoli V., Torres V., Leyden J. Global Alliance to Improve Outcomes in Acne.Understanding innate immunity and inflammationinacne: implicationsformanagement. J Eur Acad Dermatol Venereol 2015; 29 (Suppl. 4): 3—11.Gollnick H.P. From new findings in acne pathogenesis to new approaches in treatment. J Eur Acad Dermatol Venereol 2015 Jun; 29 Suppl. 5: 1—7.Nast A., Dreno B., Bettoli et. al. European Evidence-based (S3) Guidelance for the treatment of acne — update 2016-short version. J Eur Acad Dermatol Venereol 2016, 30: 1261—1268.Кубанова А.А., Кубанов А.А., Самцов А.В., Аравийская Е.А. Федеральные клинические рекомендации. Дерматовенерология 2015: Болезни кожи. Инфекции, передаваемые половым путем. 5-е изд., перераб. и доп. М.: Деловой экспресс, 2016. 768 с. [Kubanova A.A., Kubanov A.A., Samtsov A.V., Araviyskaya E.A. Federal clinical guidelines. Dermatovenerology 2015: Skin diseases. Sexually transmitted infections. 5th ed., Revised. and add. M.: Business Express 2016. 768 p. (Russia).]Cunliffe W.J., Poncet M., Loesche C., Verschoore M. A comparison of efficacy and tolerability of adapalene 0,1% gel versus tretinoin 0,025% gel in patients with acne vulgaris: a meta-analysis of five randomized trial. Br J Dermatol 1998; 139 (Suppl. 52): 48—56.Waugh J., Noble S., Scott L.J. Adapalene: a review of its use in the treatment of acne vulgaris. Drugs 2004; 64 (13): 1465—1478.Baran R., Maibach H.I. Textbook of cosmetic Dermatology. Martin Dunitz Ltd. 1998: 99—167.Misery L. Peauxréactives: mythesouréalités? Réalitésthérapeutiquesen Dermato-vénéréologie. Mai 2006. № 157.Kuhlman D., Callen J. A comparison of clindamycin phosphate 1 percent topical lotion and placebo in the treatment of acne vulgaris. Cutis. 1986; 38: 203—206.Katsambas A., Towarky A.A., Stratigos J. Topical clindamycin phosphate compared with oral tetracycline in the treatment of acne vulgaris. Br J Dermatol 1987; 116: 387—91.Rosso J., Schmidt N. A review of the anti-inflammatory properties of clindamycin in the treatment of acne vulgaris. Cutis. 2010; 85: 15—24.Wolf J.E., Kaplan D., Kraus S.J. et al. Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study. J Am Acad Dermatol 2003; 49 (3 Suppl): P. 211—217.Thiboutot D., Gollnick H. New insights into the management of acne: an update from the Global Alliance to improve outcomes in acne group. J Am Acad Dermatol 2009; 60: 150.Campbell J.L. Jr. A comparative review of the efficacy and tolerability of retinoid-containing combination regimens for the treatment of acne vulgaris. J Drugs Dermatol 2007; 6 (6): 625—629.Weiss J.S., Shavin J.S. Topical retinoid and antibiotic combination therapy for acne management. J Drugs Dermatol 2004; 3 (2): 146—154.Chandran S. et al. Microsponge – A Novel Drug Delivery System: An Overview, Indo Am. J. P. Sci 2018; 05 (05).Namrata Jadhav et al. Microsponge Delivery System: An updated review, current status and future prospects. Journal of Scientific and Innovative Research 2013; 2 (6): 1097—1110.Raghu Rama Rao G., Sanjay Ghosh, Rachita Dhurat et al. Efficacy, safety, and tolerability of microsphere adapalene vs. conventional adapalene for acne vulgaris. International Journal of Dermatology 2009, 48: 1360—1365.