Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov118710.25208/vdv1187Research ArticleExceptional case of a granuloma faciale with extrafacial involvementShpiliyukRada G.<p>dermatovenerologist</p>Shrdd91@yandex.ruAntonovaOlga V.<p>assistant lecturer</p>lecja@bk.ruBelousovaIrena E.<p>MD, Dr. Sci. (Med.), Professor</p>irena.belousova@mail.ruSamtsovAleksey V.<p>MD, Dr. Sci. (Med.), Professor</p>avsamtsov@mail.ruMilitary Medical Academy named after S.M. Kirov Ministry of Defense of the Russian Federation1512202096636410111202024122020Copyright © 2020, Shpiliyuk R.G., Antonova O.V., Belousova I.E., Samtsov A.V.2020<p>The description of obsevation of rare dermatosis granuloma faciale is presented. Modern view about etiology, clinical picture, pathogenesis of GF is mentioned. Modern ways of treatment are considered.</p>granuloma facialeextrafacial involvementdapsoneгранулема лицаэкстрафациальная локализациядапсон[Daniel AR, Darius RM. Granuloma faciale: distribution of the lesions and review of the literature. Cutis 2003;72:213–219.][Pinkus H. Granuloma faciale. Dermatologica. 1952;105:85–99.][Black CI. Granuloma faciale. Cutis. 1977;20:66–68.][Castellano-Howard L, Fairbee SI, Hogan DJ, et al. Extrafacial granulo-ma faciale: report of a case and response to treatment. Cutis. 2001;67:413–415.][Koplon BS, Wood MG. Granuloma faciale: first reported case in a Negro. Arch Dermatol. 1967;96:188–192.][Richie EB, Alfaro PJ. Multiple papular facial granulomas with eosinophilia [letter]. Arch Dermatol. 1966;94:387.][Nieboer C, Kalsbeek GL. Immunofluorescence studies in granuloma eosinophilicumfaciale. J Cutan Pathol. 1978;5:68–75.][Ackerman AB, Chongchitnant N, Sanchez J. Histologic diagnosis of Inflammatory skin diseases: an algorithmic method based on pattern analysis. 2nd ed. Baltimore: Williams and Wilkins; 1997.][Yiannias J, El-Azhary RA, Gibson LE. Erythema elevatumdiutinum: a clinical and histopathologic study of 13 patients. J Am Acad Dermatol. 1992;26:38–44.][Johnson WC, Higdon RS, Helwig EB. Granuloma faciale. Arch Dermatol. 1959;79:42–52.][Ortonne N, Wechsler J, Bagot M, et al. Granuloma faciale: a clini-copthologic study of 66 patients. J Am Acad Dermatol 2005;(6):1002–1009.][Marcoval J, Moreno A, Peyri J. Granuloma faciale: a clinico-pathologcal study of 11 cases. J Am Acad Dermatol 2004;(2):269–273.][Frankel DH, Soltani K, Medencia MM, et al. Tinea of the face caused by Trichophyton rubrum with histologic changes of granuloma fa-ciale. J Am Acad Dermatol. 1988;18:403–406.][Gomezde la Fuente E, del Rio R, Rodriquez M, et al. Granuloma faciale mimicking rhinophyma: response to clofazimine. Acta Derm Vene-reol. 2000;80:144–159.][Vassalo C, Derlino F, Croci GA, Brazzelli V, Borroni G. Chronic localized leukocytoclastic vasculitis: clinicopathological spectrum of granlomafaciale with and without extrafacial and mucosal involvement. G Ital Dermatol Venereol 2015;(1):87–94.][Sears JK, Gitter DG, Stones MS. Extrafacial granuloma faciale. Arch Dermatol 1991;(127):742–743.][Horn T. Long-standing erythematous facial plaques. Granuloma faciale. Arch Dermatol 1985;121:1553–1554,1556–1557.][Phillips DK, Hymes SR. Recurrent facial plaques following full thickness grafting. Granuloma faciale. Arch Dermatol. 1994;130:1433–1434, 1436–1437.][Jacyk WK. Facial granuloma in a patient treated with cloazimine. Arch Dermatol 1981;117:597–598.][Van de Kerkhof PC. On the efficacy of dapsone in granuloma fa-ciale. Acta Dermatol Venereol 1994;74:61–62.][Graham GF, Stewart R. Cryosurgery for unusual cutaneous neo-plasms. J Dermatol Surg Oncol 1977;3:437–442.]