Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov118910.25208/vdv1189Research ArticleStudy of the psychoemotional status of patients with medium and severe acne severity on the background of isotretinoin monotherapy (Sotret)KonnovPavel E.<p>MD, Cand. Sci. (Med), assistant professor</p>konnoff@yandex.ruhttps://orcid.org/0000-0002-6505-7943ArsenievaAntonina A.<p>MD, Cand. Sci. (Med.), assistant professor</p>a.arsenieva2014@yandex.ruhttps://orcid.org/0000-0002-7933-3515TokarevYuri A.<p>Cand. Sci. (Econ.), assistant professor</p>tokarev_ya@mail.ruhttps://orcid.org/0000-0001-9842-8504Federal State Budgetary Educational Institution of Higher Education “Samara State Medical University” of the Ministry
of Healthcare of the Russian FederationSamara State University of Economics1512202096648552411202015012021Copyright © 2020, Konnov P.E., Arsenieva A.A., Tokarev Y.A.2020<p><strong>Rationale.</strong> Acne vulgaris is a widespread chronic disease with no age, gender, or race restrictions. It does not pose a direct threat to the patient's life, but is reflected in his psycho-emotional status, which requires appropriate medical intervention.</p>
<p><strong>Purpose of the study.</strong> To study the psychoemotional status of patients aged 2224 years with moderate and severe acne and its changes during monotherapy with isotretinoin (Sotret).</p>
<p><strong>Methods.</strong> In an open, non-randomized study lasting 12 months, 310 students of the Samara State Medical University were included (52% healthy, 33% with mild acne, 13% with a moderate degree, 2% with a severe degree). All patients in the study before treatment and after 3, 6, 12 months were assessed the severity of the course using the dermatological index of acne (DIA); quality of life assessment using the Cardiff Acne Disability Index (CADI scale); assessment of the psychological and social impact of acne using the APSEA questionnaire. All patients received monotherapy using the drug Erase. The median and interquartile distance Me (Q3-Q1) were indicated as descriptive statistics. The Wilcoxon signed rank test was used to compare related groups. The comparison was carried out with 95% confidence.</p>
<p><strong>Results.</strong> An analysis of the assessment of the psychological and social status of patients with moderate and severe acne before treatment, 3, 6, 12 months after the start of treatment with isotretinoin (Erase) is presented. The study included 36 people (20 women and 16 men) aged 22 to 24 years with a disease duration from 1 to 10 years. The results of psychological testing at various intervals gave comparable data: all patients had a pronounced persistent level of social maladjustment. An important indicator of the effectiveness of acne therapy with isotretinoin is the frequency of cases of the formation of a persistent clinical effect from treatment, which is clearly expressed in the restoration of the psycho-emotional background of patients, improving the quality of life of patients.</p>
<p><strong>Conclusion.</strong> An important indicator of the effectiveness of acne therapy with Erase is the frequency of cases of the formation of a stable clinical effect of treatment, which is clearly expressed in the restoration of the psycho-emotional background of patients, improving the quality of life of patients. The treatment allowed us to change the psychoemotional background of our patients for the better, which increased their motivation to study, communication, and the desire for self-development.</p>acneisotretinoinSotretAcne Dermatological Index (DIA)Cardiff Acne Disability Index (CADI scale)APSEA questionnaireакнеизотретиноинпрепарат Сотретдерматологический индекс акне (ДИА)Кардиффский индекс акне-инвалидизации (шкала CADI)опросник APSEA[Самцов А. В., Аравийская Е. Р. и др. Федеральные клинические рекомендации по ведению больных акне. М., РОДВК, 2015. 23 c. [Samtsov AV, Araviyskaya ER, et al. Federal clinical guidelines for the management of acne patients. M., RODVK, 2015. 23 p. (In Russ.)]][Gollnick HP, Zouboulis CC. Not all acne is acne vulgaris. Dtsch Arztebl Int. 2014 Apr 25; 111(17):301–12.][doi: 10.3238 / arztebl.2014.0301][Pawin H, Chivot M, Beylot C, et al. Living with acne. A study of adolescents' personal experiences. Dermatology. 2007; 215(4):308–14.][doi: 10.1159/ 00010762][Plewig G, Kligman AM. Acne and rosacea. Springer Science & Business Media, 2012. P. 270. doi: 10.1007/978-3-642-97234-8][Dréno B, Pécastaings S, Corvec S, et al. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018 Jun; 32 Suppl 2:5–14.][doi: 10.1111 / jdv.15043][Rocha MA, Costa CS, Bagatin E. Acne vulgaris: an inflammatory disease even before the onset of clinical lesions. Inflamm Allergy Drug Targets. 2014; 13(3):162–7. doi:10.2174/1871528113666140606110024][Федеральные клинические рекомендации. Дерматовенерология 2015: Болезни кожи. Инфекции, передаваемые половым путем. 5-е изд., перераб. и доп. М.: Деловой экспресс, 2016;768 с. [Federal clinical guidelines. Dermatology 2015: diseases of the skin. Sexually transmitted infections. 5th ed., reprint. Moscow: Delovoy express, 2016;768 p. (In Russ.)]][Nast A, Dréno B, Bettoli V, et al. European evidence-based (S3) guideline for the treatment of acne — update 2016 — short version. J Eur Acad Dermatol Venereol. 2016 Aug; 30(8):1261–8. doi: 10.1111 / jdv.13776][Franzke N, Zimmer L, Schäfer I, et al. Quality of medical care of patients with acne vulgaris in Germany — nationwide survey of pharmacy clients. J Dtsch Dermatol Ges. 2009 Dec; 7(12):1060–3.][doi: 10.1111 / j.1610-0387.2009.07155][Стаценко А. В., Белоусова И. Э., Хайрутдинов В. Р. и др. Клинический опыт применения изотретиноина в терапии тяжелых форм акне. Эффективная фармакотерапия. 2014;1(4):4–6. [Statsenko AV, Belousova IE, Khairutdinov VR, et al. Clinical experience of isotretinoin use in the treatment of severe acne. Effective pharmacotherapy. 2014;1 (4):4–6 (In Russ.)]][Арипова М. Л., Хардикова С. А. Психоэмоциональное состояние пациентов с тяжелой степенью акне на фоне терапии изотретиноином. Вестник дерматологии и венерологии. 2015;91(5):122–127. [Aripova ML, Hardikova SA. Psychoemotional state of patients with severe acne on the background of isotretinoin therapy. Vestnik of Dermatology and Venereology. 2015; 91(5):122–127 (In Russ.)]]