Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov12210.25208/0042-4609-2015-91-2-49-57SHORT COMMUNICATIONКРАТКИЕ СООБЩЕНИЯNeurosyphilis in HIV-infected patientsНейросифилис на фоне ВИЧ-инфекцииKrasnoselskikhT. V.КрасносельскихТ. В.
Russian Federation
tatiana.krasnoselskikh@gmail.comSokolovskiyE. V.СоколовскийЕ. В.
Russian Federation
First Pavlov State Medical UniversityГБОУ ВПО ПСПбГМУ им. акад. И.П. Павлова Минздрава России24042015912495724082017Copyright ©; 2015, Krasnoselskikh T.V., Sokolovskiy E.V.Copyright ©; 2015, Красносельских Т.В., Соколовский Е.В.2015Krasnoselskikh T.V., Sokolovskiy E.V.Красносельских Т.В., Соколовский Е.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/122

A review article is addressed the issue of the diagnosis and treatment of neurosyphilis that is developing against the background of HIV-infection. HIV-infected patients are at higher risk of neurologic, ocular and auricular manifestation of syphilis as well as treatment failures and relapses. Diagnosis of neurosyphilis in HIV-positive patients is complicated because both infections cause similar changes in the cerebrospinal fluid (CSF). The effectiveness of neurosyphilis treatment in patients with HIV co-infection is difficult to estimate, since the normalization of their CSF goes slower comparing to HIV-negatives. The increase in incidence of syphilis and HIV co-infection is anticipated in the coming years. This necessitates a comprehensive study of the problem and requires the development of new approaches to neurosyphilis diagnosis and treatment in co-infected patients.

Обзорная статья посвящена особенностям диагностики и лечения нейросифилиса, развивающегося на фоне ВИЧ-инфекции. ВИЧ-инфицированные больные сифилисом подвержены более высокому риску возникновения специфических поражений нервной системы, органов зрения и слуха, у них выше вероятность неудач в лечении сифилиса и возникновения нейрорецидивов. Диагностика нейросифилиса у ВИЧ-позитивных больных затруднена, поскольку обе инфекции вызывают сходные изменения в цереброспинальной жидкости. Эффективность терапии нейросифилиса на фоне коинфекции трудно оценить, так как нормализация состава ликвора у ВИЧ-позитивных пациентов происходит медленнее, чем у ВИЧ-негативных. Прогнозируемое в ближайшие годы увеличение частоты встречаемости сочетанных заражений сифилисом и ВИЧ диктует необходимость всестороннего изучения данной проблемы и совершенствования подходов к диагностике и лечению нейросифилиса при коинфекции.

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