<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1243</article-id><article-id pub-id-type="doi">10.25208/vdv1243</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Rhinophyma: patient management</article-title><trans-title-group xml:lang="ru"><trans-title>Ринофима: тактика ведения пациента</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7689-8350</contrib-id><contrib-id contrib-id-type="spin">6938-4768</contrib-id><name-alternatives><name xml:lang="en"><surname>Drozhdina</surname><given-names>Marianna B.</given-names></name><name xml:lang="ru"><surname>Дрождина</surname><given-names>Марианна Борисовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand Sci. (Med.), assistant professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>drozhdina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2306-1423</contrib-id><contrib-id contrib-id-type="spin">2534-4480</contrib-id><name-alternatives><name xml:lang="en"><surname>Bobro</surname><given-names>Varvara A.</given-names></name><name xml:lang="ru"><surname>Бобро</surname><given-names>Варвара Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>bobro.va@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kirov State Medical Academy</institution></aff><aff><institution xml:lang="ru">Кировский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2022</year></pub-date><volume>98</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>64</fpage><lpage>71</lpage><history><date date-type="received" iso-8601-date="2021-05-02"><day>02</day><month>05</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2022-01-31"><day>31</day><month>01</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Drozhdina M.B., Bobro V.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Дрождина М.Б., Бобро В.А.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Drozhdina M.B., Bobro V.A.</copyright-holder><copyright-holder xml:lang="ru">Дрождина М.Б., Бобро В.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/1243">https://vestnikdv.ru/jour/article/view/1243</self-uri><abstract xml:lang="en"><p>Rhinophyma is a rare subtype of rosacea, which is a thickening of the skin in the nasal area due to an overgrowth of the sebaceous glands and the underlying connective tissue. The exact pathogenesis of rhinophyma is unknown, but potential factors include a combination of neurovascular disorders, innate immune responses, and the presence of microorganisms. The article presents current data on the treatment of rosacea, in particular, rhinophyma. A clinical case of a 67-year-old patient with a combination of papulo-pustular subtype of rosacea and rhinophyma is presented. The high effectiveness of the therapy with systemic isotretinoin was demonstrated.</p></abstract><trans-abstract xml:lang="ru"><p>Ринофима — редкий подтип розацеа, который представляет собой утолщение кожи в области носа вследствие разрастания сальных желез и подлежащей соединительной ткани. Точный патогенез ринофимы неизвестен, но потенциальные факторы включают сочетание нервно-сосудистых нарушений, врожденных иммунных ответов, присутствие микроорганизмов. В статье приводятся современные данные о лечении розацеа, в частности, ринофимы. Представлен клинический случай пациента 67 лет с сочетанием папуло-пустулезного подтипа розацеа и ринофимы. Продемонстрирована высокая результативность проведенной терапии системным изотретиноином.</p></trans-abstract><kwd-group xml:lang="en"><kwd>rhinophyme</kwd><kwd>rosacea</kwd><kwd>systemic isotretinoin</kwd><kwd>Lidose</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ринофима</kwd><kwd>розацеа</kwd><kwd>системный изотретиноин</kwd><kwd>Lidose</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Tan J, Berg M. Rosacea: current state of epidemiology. J Am Acad Dermatol 2013;69:27–35. doi: 10.1016/j.jaad.2013.04.043</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Tüzün Y, Wolf R, Kutlubay Z, Karakuş O, Engin B. Rosacea and rhinophyma. Clin Dermatol 2014;32:35–46. doi: 10.1016/j.clindermatol.2013.05.024</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Walter S, Krueger S, Ho J, Reddy KK. Unilateral rhinophyma: report of a case and review. PlastAesthet Res 2017;4:49–53. doi: 10.20517/2347-9264.2017.08</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Marks R, Harcourt-Webster JN. Histopathology of rosacea. Arch Dermatol 1969;100:683–691.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Powell FC, Raghallaigh SN. Rosacea and related disorders. In: Bolognia JL, Schaffer JV, Jorizzo JL, editors. Dermatology. 3rd. Philadelphia: Elsevier Saunders; 2012. P. 561–570.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Rohrich RJ, Griffin JR, Adams WP. Rhinophyma: review and update. Plast Reconstr Surg. 2002;110(3):860–869; quiz 870. doi: 10.1097/00006534-200209010-00023</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Jansen T, Plewig G. Clinical and histological variants of rhinophyma, including nonsurgical treatment modalities. Facial Plast Surg. 1998;14(4):241–253. doi: 10.1055/s-2008-1064456</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>el-Azhary RA, Roenigk RK, Wang TD. Spectrum of results after treatment of rhinophyma with the carbon dioxide laser. Mayo Clin Proc. 1991;66(9):899–905. doi: 10.1016/s0025-6196(12)61576-6</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Keefe M, Wakeel RA, McBride DI. Basal cell carcinoma mimicking rhinophyma. Case report and literature review. Arch Dermatol. 1988;124(7):1077–1079.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>van Zuuren EJ, Fedorowicz Z, Tan J, van der Linden MMD, Arents BWM, Carter B, et al. Interventions for rosacea based on the phenotype approach: an updated systematic review including GRADE assessments. Br J Dermatol, 181(2019):65–79. doi: 10.1111/bjd.17590</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Draelos ZD, Gold MH, Weiss RA, Baumann L, Grekin SK, Robinson DM, et al. Efficacy and safety of oxymetazoline cream 1.0% for treatment of persistent facial erythema associated with rosacea: Findings from the 52-week open label REVEAL trial. J Am Acad Dermatol. 2018;78(6):1156–1163. doi: 10.1016/j.jaad.2018.01.027</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Del Rosso JQ. Topical ivermectin: data supporting dual modes of action in rosacea. J Clin Aesthet Dermatol. 2017;10(9):39–42.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Tan J, Almeida LM, Bewley A, Cribier B, Dlova NC, Gallo R, et al. Updating the diagnosis, classification and assessment of rosacea: recommendations from the global ROSaceaCOnsensus (ROSCO) panel. Br J Dermatol. 2017;176(2):431–438. doi: 10.1111/bjd.15122</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Дрождина М.Б. Фульминантные акне. Современное решение проблемы. Вестник дерматологии и венерологии. 2019;95(4):79–86. [Drozhdina MB. Fulminant acne. Modern solution to the problem. Vestnik Dermatologii i Venerologii. 2019;95(4):79–86 (In Russ.)] doi: 10.25208/0042-4609-2019-95-4-79-86</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Дрождина М.Б. Болезнь Морбигана. Современный обзор литературы. Описание редкого клинического случая. Медицинский вестник Северного Кавказа. 2020;15(1):129–133. [Drozhdina MB. Morbihan disease. A modern review of the literature. Description of a rare clinical case. Medical news of North Caucasus. 2020;15(1):129–133 (In Russ.)] doi: 10.14300/mnnc.2020.15033</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Дрождина М.Б., Бобро В.А. Подрывающий фолликулит Гоффмана. Состояние проблемы. Подходы к терапии. Демонстрация клинических случаев. Вестник дерматологии, венерологии и косметологии. 2020;97(2):35–43. [Drozhdina MB, Bobro VA. Goffman's undermining folliculitis. State of the problem. Approach to therapy. Demonstration of clinical cases. Bulletin of Dermatology, Venereology and Cosmetology. 2020;97(2):35–43 (In Russ.)] doi: 10.25208/vdv1139</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Дрождина М.Б. Применение Акнекутана для лечения фульминантных акне. Консилиум. Дерматовенерология. 2019;2(171):25. [Drozdina MB. The usage of Aknekutan for the treatment of fulminant acne. Consultation. Dermatovenerology. 2019;2(171):25 (In Russ.)]</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Рябова В.В., Кошкин С.В., Зайцева Г.А., Евсеева А.Л. Характер распределения антигенов HLA II класса у пациентов со средне-тяжелыми и тяжелыми формами акне. Вестник дерматологии и венерологии. 2018;94(2):33–40. [Ryabova VV, Koshkin SV, Zaitseva GA, Evseeva AL. Distribution of HLA class II antigens in patients with moderate-severe and severe forms of acne. Bulletin of Dermatology and Venereology.2018;94(2):33–40 (In Russ.)]</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Nickle BS, Peterson N, Peterson M. Updated physician's guide to the off-label uses of oral isotretinoin. J Clin Aesthet Dermatol. 2014;7(4):22–34.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Gollnick H, Blume-Peytavi U, Szabó EL, Meyer KG, Hauptmann P, Popp G, et al. Systemic isotretinoin in the treatment of rosacea — doxycycline- and placebo-controlled, randomized clinical study. J Dtsch Dermatol Ges, 8(2010):505–515. doi: 10.1111/j.1610-0387.2010.07345.x</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Hofer T. Continuous 'microdose' isotretinoin in adult recalcitrant rosacea. Clin Exp Dermatol. 2004;29(2):204–205. doi: 10.1111/j.1365-2230.2004.01472.x</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Uslu M, Şavk E, Karaman G, Şendur N. Rosacea treatment with intermediate-dose isotretinoin: follow-up with erythema and sebum measurements. Acta Derm Venereol. 2012;92(1):73–77. doi: 10.2340/00015555-1204</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Walsh RK, Endicott AA, Shinkai K. Diagnosis and Treatment of Rosacea Fulminans: A Comprehensive Review. Am J Clin Dermatol. 2018;19(1):79–86. doi: 10.1007/s40257-017-0310-0</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Korting HC, Schöllmann C. Current topical and systemic approaches to treatment of rosacea. J Eur Acad Dermatol Venereol, 23(2009):876–882. doi: 10.1111/j.1468-3083.2009.03167.x</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Wee JS, Tan KB. Phymatous rosacea presenting with leonine facies and clinical response to isotretinoin. Australias J Dermatol, 58 (2017). P. 72–73. doi: 10.1111/ajd.12505</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Haber R, El Gemayel M. Comorbidities in rosacea: A systematic review and update. J Am Acad Dermatol. 2018;78(4):786–792.e8. doi: 10.1016/j.jaad.2017.09.016</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>van Zuuren EJ. Rosacea. N Engl J Med. 2017 Nov 2;377(18):1754–1764. doi: 10.1056/NEJMcp1506630</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Halioua B, Cribier B, Frey M, Tan J. Feelings of stigmatization in patients with rosacea. J Eur Acad Dermatol Venereol. 2017 Jan;31(1):163–168. doi: 10.1111/jdv.13748</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Madan V, Ferguson JE, August PJ. Carbon dioxide laser treatment of rhinophyma: a review of 124 patients. Br J Dermatol. 2009;161(4):814–818. doi: 10.1111/j.1365-2133.2009.09317.x</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Payne WG, Ko F, Anspaugh S, Wheeler CK, Wright TE, Robson MC. Down-regulating causes of fibrosis with tamoxifen: a possible cellular/molecular approach to treat rhinophyma. Ann Plast Surg. 2006;56(3):301–305. doi: 10.1097/01.sap.0000199155.73000.2f</mixed-citation></ref></ref-list></back></article>
