Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov127510.25208/vdv1275CLINICAL CASE REPORTSНАБЛЮДЕНИЕ ИЗ ПРАКТИКИResearch ArticleHerpes zoster following COVID-19 vaccination: about 2 casesBen SalahNesrine
Tunisia
nesrinebensalah2612019@gmail.comLahouelInes
Tunisia
nesrinebensalah2612019@gmail.comManaaLinda
Tunisia
nesrinebensalah2612019@gmail.comSouaYosra
Tunisia
nesrinebensalah2612019@gmail.comYoussefMonia
Tunisia
nesrinebensalah2612019@gmail.comBelhadjaliHichem
Tunisia
nesrinebensalah2612019@gmail.comZiliJameleddine
Tunisia
nesrinebensalah2612019@gmail.comUniversity of Monastir, Department of Dermatology1501202298172741409202108022022Copyright ©; 2022, Ben Salah N., Lahouel I., Manaa L., Soua Y., Youssef M., Belhadjali H., Zili J.Copyright ©; 2022, Ben Salah N., Lahouel I., Manaa L., Soua Y., Youssef M., Belhadjali H., Zili J.2022Ben Salah N., Lahouel I., Manaa L., Soua Y., Youssef M., Belhadjali H., Zili J.Ben Salah N., Lahouel I., Manaa L., Soua Y., Youssef M., Belhadjali H., Zili J.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/1275

The COVID-19 vaccine often well tolerated in healthy adults at the same time, different cutaneous reactions have been reported. Two cases presented of developed a first episode of Herpes zoster (HZ) following the first dose of vaccination against COVID-19. The pathogenetic mechanism suggested that SARS-CoV-2 infection can induce a decrease of blood absolute lymphocyte number, especially CD3+ CD8+ lymphocyte. The COVID-19 vaccine, by stimulation of inflammatory cytokines, may negatively affect the antigen expression and contribute to HZ reactivation. It is also possible that the vaccine induces some kind of immunomodulation that allows VZV to revert an infectious state.

Herpes ZosterCOVID-19vaccineMcMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. J Am Acad Dermatol. 2021;85(1):46–55. doi: 10.1016/j.jaad.2021.03.092Gershon AA, Gershon MD, Breuer J, Levin MJ, Oaklander AL, Griffiths PD. Advances in the understanding of the pathogenesis and epidemiology of herpes zoster. J Clin Virol. 2010;48 Suppl 1(Suppl 1):S2-7. doi: 10.1016/S1386-6532(10)70002-0Rodríguez-Jiménez P, Chicharro P, Cabrera LM, Seguí M, Morales-Caballero Á, Llamas-Velasco M, et al. Varicella-zoster virus reactivation after SARS-CoV-2 BNT162b2 mRNA vaccination: Report of 5 cases. JAAD Case Rep. 2021;12:58–59. doi: 10.1016/j.jdcr.2021.04.014Tartari F, Spadotto A, Zengarini C, Zanoni R, Guglielmo A, Adorno A, Valzania C, Pileri A. Herpes zoster in COVID-19-positive patients. Int J Dermatol. 2020;59(8):1028-1029. doi: 10.1111/ijd.15001Furer V, Zisman D, Kibari A, Rimar D, Paran Y, Elkayam O. Herpes zoster following BNT162b2 mRNA COVID-19 vaccination in patients with autoimmune inflammatory rheumatic diseases: a case series. Rheumatology (Oxford). 2021;60(SI):SI90-SI95. doi: 10.1093/rheumatology/keab345