Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov1310.25208/0042-4609-2014-90-1-81-88DRUG TREATMENT IN DERMATOVENEROLOGYФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИLong-term therapy of severe acne: selection of doses and administration schemes for systemic isotretinoinДлительная терапия больных с тяжелым течением акне: выбор доз и схем приема системного изотретиноинаBakulevA. L.БакулевА. Л.
Russian Federation
al_ba05@mail.ruKravchenyaS. S.КравченяС. С.
Russian Federation
PlatonovaA. N.ПлатоноваА. Н.
Russian Federation
IgoninaI. A.ИгонинаИ. А.
Russian Federation
Saratov State Medical University named after V.I. Razumovsky BolshayaГБОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России24022014901818824082017Copyright ©; 2014, Bakulev A.L., Kravchenya S.S., Platonova A.N., Igonina I.A.Copyright ©; 2014, Бакулев А.Л., Кравченя С.С., Платонова А.Н., Игонина И.А.2014Bakulev A.L., Kravchenya S.S., Platonova A.N., Igonina I.A.Бакулев А.Л., Кравченя С.С., Платонова А.Н., Игонина И.А.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/13

The article presents current data on the application of a systemic retinoid, isotretinoin, on the basis of the Lidose system for the treatment of patients with severe forms of acne. It also discusses issues of optimization of the daily dose of isotretinoin taking into consideration long-term clinical efficacy and safety of the therapy. The article presents the results of the authors’ study demonstrating the possibility to select mainly large or small doses of systemic isotretinoin depending on the treatment duration.

Приводятся современные данные о применении системного ретиноида изотретиноина на основе системы Lidose в лечении больных с тяжелыми формами акне. Обсуждаются вопросы оптимизации суточной дозы изотретиноина с учетом долгосрочной клинической эффективности и безопасности проводимой терапии. Приводятся результаты собственного исследования, демонстрирующие возможность выбора преимущественно больших, либо малых доз системного изотретиноина в зависимости от длительности предпринятого лечения.

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