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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1302</article-id><article-id pub-id-type="doi">10.25208/vdv1302</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASE REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЕ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Scleroderma-like form of lipoid necrobiosis in a patient with idiopathic thrombocytopenic purpura</article-title><trans-title-group xml:lang="ru"><trans-title>Склеродермоподобная форма липоидного некробиоза у пациентки с идиопатической тромбоцитопенической пурпурой</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4837-8489</contrib-id><contrib-id contrib-id-type="spin">2330-2758</contrib-id><name-alternatives><name xml:lang="en"><surname>Perlamutrov</surname><given-names>Yuriy N.</given-names></name><name xml:lang="ru"><surname>Перламутров</surname><given-names>Юрий Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>y.perlamutrov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8821-7903</contrib-id><contrib-id contrib-id-type="spin">5240-0869</contrib-id><name-alternatives><name xml:lang="en"><surname>Svishchenko</surname><given-names>Svetlana I.</given-names></name><name xml:lang="ru"><surname>Свищенко</surname><given-names>Светлана Игорьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. (Sci.) Med.</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>svischenko@cnikvi.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="spin">2866-9965</contrib-id><name-alternatives><name xml:lang="en"><surname>Pugner</surname><given-names>Anna S.</given-names></name><name xml:lang="ru"><surname>Пугнер</surname><given-names>Анна Степановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>dermatovenereologist</p></bio><bio xml:lang="ru"><p>врач-дерматовенеролог</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow State University of Medicine and Dentistry named after A.I. Evdokimov</institution></aff><aff><institution xml:lang="ru">Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">State Research Center of Dermatovenereology and Cosmetology</institution></aff><aff><institution xml:lang="ru">Государственный научный центр дерматовенерологии и косметологии</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-05-25" publication-format="electronic"><day>25</day><month>05</month><year>2022</year></pub-date><volume>98</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>73</fpage><lpage>80</lpage><history><date date-type="received" iso-8601-date="2021-12-30"><day>30</day><month>12</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2022-04-10"><day>10</day><month>04</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Perlamutrov Y.N., Svishchenko S.I., Pugner A.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Перламутров Ю.Н., Свищенко С.И., Пугнер А.С.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Perlamutrov Y.N., Svishchenko S.I., Pugner A.S.</copyright-holder><copyright-holder xml:lang="ru">Перламутров Ю.Н., Свищенко С.И., Пугнер А.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/1302">https://vestnikdv.ru/jour/article/view/1302</self-uri><abstract xml:lang="en"><p>A 33-year-old female patient with idiopathic thrombocytopenic purpura complained of rashes on the skin of the lower extremities, accompanied by moderate itching and a feeling of skin tightness, as well as a histologically verified diagnosis of lipoid necrobiosis. A combined treatment was carried out with the glucocorticosteroid Methylprednisolone at a dose of 32 mg per day in combination with PUVA therapy with 0.3% solution of ammi majus fructuum furocumarines, with a positive effect in the form of a decrease in the color intensity and induction of rashes, under the control of platelet levels. When using the method of PUVA-therapy with 0.3% solution of ammi majus fructuum furocumarines, there was an improvement in the 8th phototherapy procedure, however, due to a decrease in the level of platelets in the blood, the course of phototherapy was suspended.</p> <p>The method of PUVA therapy with 0.3% solution of ammi majus fructuum furocumarines turned out to be clinically effective in the treatment of lipoid necrobiosis, however, the presence of concomitant pathology in the patient requires an interdisciplinary approach to the choice of treatment tactics.</p></abstract><trans-abstract xml:lang="ru"><p>Пациентка 33 лет с идиопатической тромбоцитопенической пурпурой обратилась с жалобами на высыпания на коже нижних конечностей, сопровождающиеся умеренным зудом и чувством стянутости кожи, а также гистологически верифицированным диагнозом липоидного некробиоза. Было проведено комбинированное лечение глюкокортикостероидным препаратом Метилпреднизолон в дозе 32 мг в сутки в сочетании с ПУВА-терапией с 0,3% раствором амми большой плодов фурокумарины, с положительным эффектом в виде уменьшения интенсивности окраски и индурации высыпаний, под контролем уровня тромбоцитов. При использовании метода ПУВА-терапии с 0,3% раствором амми большой плодов фурокумарины отмечалось улучшение на 8-й процедуре фототерапии, однако в связи со снижением уровня тромбоцитов в крови курс фототерапии был приостановлен.</p> <p>Применение метода ПУВА-терапии с 0,3% раствором амми большой плодов фурокумарины оказалось клинически эффективным при лечении липоидного некробиоза, однако наличие сопутствующей патологии у пациентки требует междисциплинарного подхода к выбору тактики лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>lipoid necrobiosis</kwd><kwd>PUVA-therapy</kwd><kwd>idiopathic thrombocytopenic purpura</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>клинический случай липоидного некробиоза</kwd><kwd>ПУВА-терапия</kwd><kwd>идиопатическая тромбоцитопеническая пурпура</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Sibbald C, Reid S, Alavi A. Necrobiosis Lipoidica. 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