Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov1327910.25208/vdv13279REVIEWSОБЗОР ЛИТЕРАТУРЫReview ArticleFeatures of management of atopic dermatitis in pregnant womenОсобенности ведения атопического дерматита у беременныхhttps://orcid.org/0000-0001-8688-75785548-5359AlbanovaVera I.АльбановаВера Игоревна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

albanova@rambler.ruhttps://orcid.org/0000-0003-3034-01487268-6944PetrovaStanislava Y.ПетроваСтанислава Юрьевна
Russian Federation

MD, Cand. Sci. (Med.)

к.м.н.

petrovastanislava@yandex.ruMoscow Regional Research and Clinical Institute (MONIKI)Московский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоMechnikov Research Institute of Vaccines and SeraНаучно-исследовательский институт вакцин и сывороток имени И.И. МечниковаJoint-Stock Company Pharmaceutical Enterprise “Retinoids”АО «Ретиноиды»161120231212202399529402906202323102023Copyright ©; 2023, Albanova V.I., Petrova S.Y.Copyright ©; 2023, Альбанова В.И., Петрова С.Ю.2023Albanova V.I., Petrova S.Y.Альбанова В.И., Петрова С.Ю.https://creativecommons.org/licenses/by-nc/4.0https://vestnikdv.ru/jour/article/view/13279

Atopic dermatitis (AD) is a chronic allergic skin disease, the most common of dermatoses during pregnancy. Exacerbation of AD can be at any stage of pregnancy, its main causes are an increase in progesterone levels, the predominance of Th2 cytokines, psychoemotional stress, violations of the gastrointestinal tract. Changes occur in the clinical picture, the lesions on the face and extensor surfaces of the extremities, papules. Treatment options for pregnant women are limited due to the unethical nature of clinical trials. It is safe to use topical glucocorticosteroids, moisturizers, narrow-band UVB 311 nm, calcineurin inhibitors are relatively safe. In systemic therapy in severe cases, the use of cyclosporine or a short course of prednisone is recommended. There is no evidence of the safety of selective immunosuppressants.

Атопический дерматит (АД) — хроническое аллергическое заболевание кожи. Данное заболевание является наиболее частым из дерматозов во время беременности. Обострение АД может быть в любом сроке беременности. Его основные причины — повышение уровня прогестерона, преобладание Th2-цитокинов, психоэмоциональный стресс, нарушение деятельности желудочно-кишечного тракта. В клинической картине происходят изменения, преобладают поражение лица и разгибательных поверхностей конечностей, папулезные высыпания. Возможности лечения беременных женщин ограничены из-за неэтичности проведения клинических испытаний. Безопасно использование топических глюкокортикостероидов, увлажняющих средств, узкополосного УФВ 311 нм, относительно безопасны ингибиторы кальциневрина. В системной терапии при тяжелом течении рекомендуется применение циклоспорина или короткого курса преднизолона. Доказательства безопасности селективных иммунодепрессантов отсутствуют.

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