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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">133</article-id><article-id pub-id-type="doi">10.25208/0042-4609-2015-91-2-130-138</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DRUG TREATMENT IN DERMATOVENEROLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Justification of the efficacy of antibacterial therapy for the treatment of chronic endometritis</article-title><trans-title-group xml:lang="ru"><trans-title>Обоснование эффективности антибактериальной терапии в лечении хронической воспалительной болезни матки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tapilskaya</surname><given-names>N. I.</given-names></name><name xml:lang="ru"><surname>Тапильская</surname><given-names>Н. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>tapnatalia@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karpeyev</surname><given-names>S. A.</given-names></name><name xml:lang="ru"><surname>Карпеев</surname><given-names>С. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gaidukov</surname><given-names>S. N.</given-names></name><name xml:lang="ru"><surname>Гайдуков</surname><given-names>С. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">St. Petersburg State Pediatric Medical University (State Budgetary Educational Institution for Higher Professional education), Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">«Konsul'tativno-diagnosticheskij centr s poliklinikoj» Upravlenija delami Prezidenta RF</institution></aff><aff><institution xml:lang="ru">ФГБУ «Консультативно-диагностический центр с поликлиникой» Управления делами Президента РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-04-24" publication-format="electronic"><day>24</day><month>04</month><year>2015</year></pub-date><volume>91</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>130</fpage><lpage>138</lpage><history><date date-type="received" iso-8601-date="2017-08-24"><day>24</day><month>08</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Tapilskaya N.I., Karpeyev S.A., Gaidukov S.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Тапильская Н.И., Карпеев С.А., Гайдуков С.Н.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Tapilskaya N.I., Karpeyev S.A., Gaidukov S.N.</copyright-holder><copyright-holder xml:lang="ru">Тапильская Н.И., Карпеев С.А., Гайдуков С.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/133">https://vestnikdv.ru/jour/article/view/133</self-uri><abstract xml:lang="en"><p>A review of studies on chronic endometritis enables the authors to conclude that bacterially contaminated endometrium is the reason causing reduced fertility in case of confirmed subclinical inflammation. Chronic subclinical inflammation of the endometrium is often associated with genital endometriosis, which apparently leads to abnormal uterine bleedings. The identification of a microbial agent in case of endometritis in the routine outpatient practice is not mandatory because global experience including high-level evidence-based studies confirms the expediency of an empirical therapy based on minimum clinical criteria; otherwise, there may be irreversible consequences for the reproductive system. A preventive antibacterial therapy during the pre-conception period in infertile patients suffering from recurrent miscarriages is an efficient method to prevent reproductive losses.</p></abstract><trans-abstract xml:lang="ru"><p>Обзор научных исследований, посвященных хроническому эндометриту, позволяет сделать вывод, что контаминированный микроорганизмами эндометрий при наличии подтвержденного субклинического воспаления является причиной, приводящей к снижению фертильности. Хроническое субклиническое воспаление эндометрия нередко ассоциировано с генитальным эндометриозом, что, вероятнее всего, является причиной аномальных маточных кровотечений. Обнаружение того или иного микробного агента при эндометрите в рутинной амбулаторной практике не является обязательным, так как мировой опыт, включающий научные исследования с высоким уровнем доказательности, свидетельствует о целесообразности эмпирической терапии, основанной на минимальных клинических критериях, ибо в противном случае последствия для репродуктивной системы могут быть непоправимы. Превентивная антибактериальная терапия в преконцепции у пациенток с бесплодием, привычным невынашиванием беременности является эффективным способом профилактики репродуктивных потерь.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая воспалительная болезнь матки</kwd><kwd>антибактериальная терапия</kwd><kwd>chronic endometritis</kwd><kwd>antibacterial therapy</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Wiesenfeld H.C., Hillier S.L., Meyn L.A., Amortegui A.J., Sweet R.L. Subclinical pelvic inflammatory diseaseand infertility. Obstet Gynecol 2012; 120: 37-43</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Радзинский В.Е. Димитрова В.И. Майскова И.Ю. Неразвивающаяся беременность. M.: Геотар-Медиа 2009; 196</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Munro M.G., Critchley H.O., Broder M.S., Fraser I.S.; FIGO Working Group on Menstrual Disorders. 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