Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov133010.25208/vdv1330REVIEWSОБЗОР ЛИТЕРАТУРЫReview ArticleThe role of cells of the innate immune system in psoriasisРоль клеток врожденной иммунной системы при псориазеhttps://orcid.org/0000-0002-1188-65781052-6474SorokinaEkaterina V.СорокинаЕкатерина Вячеславовна
Russian Federation

MD, Dr. Sci. (Med.)

д.м.н.

sorokina-cathrine@yandex.ruhttps://orcid.org/0000-0002-8143-73569846-1006BishevaIrina V.БишеваИрина Васильевна
Russian Federation
ibisheva@yandex.ruI.I. Mechnikov Research Institute for Vaccines and SeraНаучно-исследовательский институт вакцин и сывороток им. И.И. МечниковаFederal Medical-Biological Agency of RussiaАкадемия постдипломного образования Федерального государственного бюджетного учреждения «Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства»011120222311202298559641605202220092022Copyright ©; 2022, Sorokina E.V., Bisheva I.V.Copyright ©; 2022, Сорокина Е.В., Бишева И.В.2022Sorokina E.V., Bisheva I.V.Сорокина Е.В., Бишева И.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/1330

Psoriasis is an immune-mediated disease with a complex pathogenesis. The close relationship between the development of psoriasis and the adaptive immune response is already known. However, recent data have shown that innate immune cells also play an important role in the development of psoriasis. Congenital lymphoid cells, dendritic cells, γδ T cells, NK cells, and NKT lymphocytes are activated in psoriasis, contributing to disease pathology through IL-17-dependent and independent mechanisms. During disease progression, γδ T cells secrete proinflammatory cytokines that induce and exacerbate the course of psoriasis. γδ T cells have memory cell properties that respond rapidly to secondary stimulation, which contributes to disease relapse. This article presents an overview of recent findings demonstrating the role of innate immunity in psoriasis.

Псориаз является иммуноопосредованным заболеванием со сложным патогенезом. Уже известна тесная взаимосвязь развития псориаза с адаптивным иммунным ответом. Однако последние данные показали, что клетки врожденного иммунитета также играют важную роль в развитии псориаза. Врожденные лимфоидные клетки, дендритные клетки, γδ Т-клетки, NK-клетки и NKT-лимфоциты активируются при псориазе, внося свой вклад в патологию заболевания посредством IL-17-зависимых и независимых механизмов. Во время развития заболевания γδ Т-клетки секретируют провоспалительные цитокины, которые индуцируют и усугубляют течение псориаза. γδ Т-клетки обладают свойствами клеток памяти, которые быстро реагируют на вторичную стимуляцию, что способствует рецидиву заболевания. В статье представлен обзор последних результатов, демонстрирующих роль врожденного иммунитета при псориазе.

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