Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov134910.25208/vdv1349REVIEWSОБЗОР ЛИТЕРАТУРЫReview ArticleEfficacy and safety of treatment of moderate and severe psoriasis with the interleukin 23 inhibitor risankizumabЭффективность и безопасность лечения среднетяжелого и тяжелого псориаза ингибитором интерлейкина 23 рисанкизумабомhttps://orcid.org/0000-0002-1450-49426708-7386BakulevAndrey L.БакулевАндрей Леонидович
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

al_ba05@mail.ruhttps://orcid.org/0000-0002-5044-52651107-4372KruglovaLarisa S.КругловаЛариса Сергеевна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

kruglovals@mail.ruCentral State Medical Academy, Department of Presidential Affairs«Центральная государственная медицинская академия» Управления делами Президента Российской Федерации1909202298423301507202216082022Copyright ©; 2022, Bakulev A.L., Kruglova L.S.Copyright ©; 2022, Бакулев А.Л., Круглова Л.С.2022Bakulev A.L., Kruglova L.S.Бакулев А.Л., Круглова Л.С.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/1349

A review of the literature on the use of the genetically engineered biological drug Skyrizi (INN: risankizumab) for the treatment of psoriasis in patients is presented. The problem of high dissatisfaction of patients with the available means (methods) of therapy for this dermatosis is discussed.

Inhibition of regulatory IL-23 seems to be a very promising direction of therapy, which makes it possible to block the immunopathogenesis of the disease.

The IL-23 inhibitor risankizumab is a highly effective GEBA for the treatment of moderate to severe psoriasis in patients. The use of this drug is accompanied by a very rapid and stable therapeutic response in the form of clear or almost clear skin. Long-term use of risankizumab demonstrates the maintenance of a stable therapeutic response without a tendency to decrease.

Risankizumab has a favorable safety profile with a low risk of infections and malignancies. At the same time, such adverse events as the development of tuberculosis or inflammatory bowel disease are not typical for therapy with these GIBDs.

Представлен обзор литературы, посвященной применению генно-инженерного биологического препарата Скайризи (МНН: рисанкизумаб) для лечения псориаза у пациентов. Обсуждается проблема высокой неудовлетворенности пациентов имеющимися средствами (методами) терапии данного дерматоза.

Ингибирование регуляторного ИЛ-23 представляется весьма перспективным направлением терапии, позволяющей блокировать иммунопатогенез заболевания.

Ингибитор ИЛ-23 рисанкизумаб является высокоэффективным ГИБП для лечения среднетяжелого и тяжелого псориаза у пациентов. Применение данного лекарственного средства сопровождается весьма быстрым и стойким терапевтическим ответом в виде достижения чистой или почти чистой кожи. Долгосрочное использование рисанкизумаба демонстрирует сохранение стойкого терапевтического ответа без тенденции к его снижению.

Рисанкизумаб демонстрирует благоприятный профиль безопасности с низким риском возникновения инфекций и злокачественных новообразований. При этом такие нежелательные явления, как развитие туберкулеза или воспалительных заболеваний кишечника, не являются характерными для терапии данным ГИБП.

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