Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov141410.25208/vdv1414GUIDELINES FOR PRACTITIONERSВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУResearch ArticleTo the question of the effect of isotretinoin on the neuropsychic state of patients with acneК вопросу о влиянии изотретиноина на нервно-психическое состояние больных акнеhttps://orcid.org/0000-0002-9458-08722287-5062SamtsovAlexey V.СамцовАлексей Викторович
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

avsamtsov@mail.ruMilitary Medical Academy named after S.M. KirovВоенно-медицинская академия имени С.М. Кирова040720232507202399363681503202328062023Copyright ©; 2023, Samtsov A.V.Copyright ©; 2023, Самцов А.В.2023Samtsov A.V.Самцов А.В.https://creativecommons.org/licenses/by-nc/4.0https://vestnikdv.ru/jour/article/view/1414

Patients with acne often develop neuropsychiatric disorders of varying severity, correlating, as a rule, with the severity of dermatosis. Isotretinoin is the most commonly used drug for the treatment of moderate acne. Due to the fact that in a number of studies isotretinoin was considered as a trigger for the development of various neuropsychiatric disorders, numerous studies were conducted to prove this possibility or to refute it. An analysis of the literature showed that, according to the vast majority of studies, isotretinoin does not lead to neuropsychiatric disorders. However, given the opposite opinion of some authors, it is advisable to actively identify, including in the anamnesis, any psycho-emotional disorders, and monitor them during therapy. In these cases, it is indicated to start treatment with small doses (recommendations have not been developed).

У больных акне часто развиваются различной степени выраженности нервно-психические нарушения, коррелирующие, как правило, с тяжестью дерматоза. Для лечения среднетяжелых форм акне наиболее широко применяется изотретиноин. В связи с тем, что в ряде работ изотретиноин рассматривали как триггер развития различных нервно-психических нарушений, были проведены многочисленные исследования с целью доказательства такой возможности или ее опровержения. Анализ литературы показал, что, по данным подавляющего большинства исследований, изотретиноин не приводит к нервно-психическим нарушениям. Однако, учитывая противоположное мнение некоторых авторов, целесообразно проводить активное выявление, в том числе в анамнезе, каких-либо психоэмоциональных расстройств и их мониторирование в процессе терапии. В этих случаях показано начинать лечение с малых доз (рекомендации не разработаны).

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