<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16749</article-id><article-id pub-id-type="doi">10.25208/vdv16749</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Xerosis: from pathogenesis to solving practical problems</article-title><trans-title-group xml:lang="ru"><trans-title>Ксероз: от патогенеза к решению практических задач</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6562-0556</contrib-id><contrib-id contrib-id-type="spin">1222-6560</contrib-id><name-alternatives><name xml:lang="en"><surname>Torshina</surname><given-names>Irina E.</given-names></name><name xml:lang="ru"><surname>Торшина</surname><given-names>Ирина Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>irina-torsina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Smolensk State Medical University</institution></aff><aff><institution xml:lang="ru">Смоленский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-11-25" publication-format="electronic"><day>25</day><month>11</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2024</year></pub-date><volume>100</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>81</fpage><lpage>91</lpage><history><date date-type="received" iso-8601-date="2024-01-10"><day>10</day><month>01</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-11-19"><day>19</day><month>11</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Irina E. Torshina</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Торшина И.Е.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Irina E. Torshina</copyright-holder><copyright-holder xml:lang="ru">Торшина И.Е.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/16749">https://vestnikdv.ru/jour/article/view/16749</self-uri><abstract xml:lang="en"><p>Xerosis is a widespread symptom of dermatoses of various etiologies and pathogenetic mechanisms, which is recorded in people of different ages with a wide range of frequency and severity. The article contains the most current data on the features of the development and clinical manifestations of xerosis in terms of its connection with various factors of endo- and exogenous nature. An analysis of modern publications devoted to the study of the mechanisms of xerosis formation depending on genetic and premorbid factors, the influence of external causes associated with the characteristics of skin care in healthy individuals, patients with endocrinopathies, infectious and non-infectious diseases, visceropathy and iatrogenics is presented. Regardless of the origin of xerosis, it is justified to include in basic therapy topical preparations of the Lipobase line based on colloidal oats in combination with auxiliary components, the systematic use of which makes it possible to relieve the symptoms of xerosis and improve the quality of patient’s life.</p></abstract><trans-abstract xml:lang="ru"><p>Ксероз — широко распространенный симптомокомплекс с разнообразными по этиологии патогенетическими механизмами развития дерматозов, который регистрируется у людей разного возраста с широким диапазоном частоты и степени выраженности. Статья содержит наиболее актуальные данные об особенностях развития и клинических проявлений ксероза в аспекте его связи с различными факторами эндо- и экзогенной природы. Представлен анализ современных наиболее актуальных публикаций, посвященных изучению механизмов формирования ксероза в зависимости от генетических и преморбидных факторов, влияния внешних причин, связанных с особенностями ухода за кожей у здоровых лиц и больных с эндокринопатиями, заболеваниями инфекционной и неинфекционной природы, патологией внутренних органов и ятрогенией. Вне зависимости от происхождения ксероза обосновано включение в базовую терапию топических препаратов линии Липобейз на основе натуральных масел в комбинации с другими активными компонентами, включая бета-глюкан овса, применение которых позволяет купировать симптоматику ксероза и повысить качество жизни больных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>xerosis</kwd><kwd>etiopathogenesis</kwd><kwd>clinical manifestations</kwd><kwd>therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ксероз</kwd><kwd>этиология и патогенез</kwd><kwd>клинические проявления</kwd><kwd>терапия</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The manuscript was prepared with the financial support of the pharmaceutical company Pharmtek LLC.</funding-statement><funding-statement xml:lang="ru">Рукопись подготовлена при финансовой поддержке фармацевтической компании ООО «Фармтек».</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Pons-Guiraud A. Dry skin in dermatology: a complex physiopathology. J Eur Acad Dermatol Venereol. 2007;21(Suppl 2):1–4. doi: 10.1111/j.1468-3083.2007.02379.x</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Augustin M, Wilsmann-Theis D, Körber A, Kerscher M, Itschert G, Dippel M, et al. Positionspapier: Diagnostic und Therapie der Xerosis cutis. J Dtsch Dermatol Ges. 2018;16(Suppl 4):3–35. doi: 10.1111/ddg.13580</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Baran R, Maibach HI. (eds) Textbook of cosmetic Dermatology. 2nd ed. London: Martin Dunitz Ltd; 1998. P. 774.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Атопический дерматит: клинические рекомендации / Российское общество дерматовенерологов и косметологов, Российская ассоциация аллергологов и клинических иммунологов Союза педиатров России, 2021. 81 с. [Atopic dermatitis: Clinical recommendations / Russian Society of Dermatovenereologists and Cosmetologists, Russian Association of Allergists and Clinical Immunologists of the Union of Pediatricians of Russia with the participation of the National Alliance of Dermatovenereologists and Cosmetologists, 2021. 81 s. (In Russ.)] URL: https://cr.minzdrav.gov.ru/recomend/265_2https://cr.minzdrav.gov.ru/recomend/265_2</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Ихтиоз: клинические рекомендации / Российское общество дерматовенерологов и косметологов, 2020. [Ichthyosis: Clinical recommendations of the Russian Society of Dermatovenereologists and Cosmetologists, 2020. (In Russ.)]</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Псориаз: клинические рекомендации / Российское общество дерматовенерологов и косметологов, 2023. [Psoriasis. Clinical recommendations of the Russian Society of Dermatovenereologists and Cosmetologists, 2023. (In Russ.)] URL: https://cr.minzdrav.gov.ru/schema/234_2</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Serup J. EEMCO Guidance for the Assessment of Dry Skin (Xerosis) and Ichthyosis: Clinical Scoring Systems. Skin Res Technol. 1995;1(3):109–114. doi: 10.1111/j.1600-0846.1995.tb00029.x</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Butala S, Mazereeuw-Hautier J, Paller AS. Ichthyosis: presentation and management. Curr Opin Pediatr. 2023;35(4):467–474. doi: 10.1097/MOP.0000000000001264</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Экзема: клинические рекомендации / Российское общество дерматовенерологов и косметологов, 2021. [Eczema: Clinical recommendations of the Russian Society of Dermatovenereologists and Cosmetologists. (In Russ.)] URL: https://cr.minzdrav.gov.ru/recomend/246_2</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Danby SG, Brown K, Wigley AM, Chittock J, Pyae PK, Flohr C, et al. The Effect of Water Hardness on Surfactant Deposition after Washing and Subsequent Skin Irritation in Atopic Dermatitis Patients and Healthy Control Subjects. J Invest Dermatol. 2018;138(1):68–77. doi: 10.1016/j.jid.2017.08.037</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Engebretsen KA, Bager P, Wohlfahrt J, Skov L, Zachariae C, Nybo Andersen AM, et al. Prevalence of atopic dermatitis in infants by domestic water hardness and season of birth: Cohort study. J Allergy Clin Immunol. 2017;139(5):1568–1574.e1. doi: 10.1016/j.jaci.2016.11.021</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Jabbar-Lopez ZK, Craven J, Logan K, Greenblatt D, Marrs T, Radulovic S, et al. Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene-environment interaction. Br J Dermatol. 2020;183(2):285–293. doi: 10.1111/bjd.18597</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Торшина И.Е., Роева Д.А., Хворик Д.Ф., Никуличева А.С., Гужва И.В., Луговая А.А. Средства индивидуальной защиты как причина инициации, осложнения заболеваний кожи и формирования новых нозологий в клинической практике (по результатам многоцентрового социологического исследования). Смоленский медицинский альманах. 2023;1:92–95. [Torshina IE, Roeva DA, Khvorik DF, Nikulicheva AS, Guzhva IV, Lugovaya AA. Personal protective equipment as a cause of initiation, complications of skin diseases and the formation of new nosologies in clinical practice (according to the results of a multicenter sociological study). Smolensky Medical Almanac. 2023;1:92–95. (In Russ.)] doi: 10.37903/SMA.2023.1.18</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Холодилова Н.А., Монахов К.Н. Оценка клинической эффективности средств на основе синтетического танина и полидоканола, современных эмолентов при лечении экземы кистей. Использование новых антисептиков для рук в период пандемии у пациентов с экземой кистей. Клиническая дерматология и венерология. 2022;21(1):59–67. [Kholodilova NA, Monakhov KN. Evaluation of clinical efficacy of synthetic tannin and polidocanol-based agents and modern emollients in the hand eczema treatment. Use of new hand antiseptics during the pandemic in patients with hand eczema. Russian Journal of Clinical Dermatol and Venereol = Klinicheskaya dermatologiya i venerologiya. 2022;21(1):59–67. (In Russ.)] doi: 10.17116/klinderma20222101159</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Kalaaji AN, Wallo W. A randomized controlled clinical study to evaluate the effectiveness of an active moisturizing lotion with colloidal oatmeal skin protectant versus its vehicle for the relief of xerosis. J Drugs Dermatol. 2014;13(10):1265–1268.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Misery L, Ezzedine K, Corgibet F, Dupin N, Sei JF, Philippe C, et al. Sex- and age-adjusted prevalence estimates of skin types and unpleasant skin sensations and their consequences on quality of life: results of a study of a large representative sample of the French population. Br J Dermatol. 2019;180(6):1549–1550. doi: 10.1111/bjd.17467</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Henning MA, Ibler KS, Ullum H, Erikstrup C, Bruun MT, Burgdorf KS, et al. The association between water hardness and xerosis — results from the Danish Blood Donor Study. PLoS One. 2021;16(6):e0252462. doi: 10.1371/journal.pone.0252462</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Tanaka A, Matsuda A, Jung K, Jang H, Ahn G, Ishizaka S, et al. Ultra-pure soft water ameliorates atopic skin disease by preventing metallic soap deposition in NC/Tnd mice and reduces skin dryness in humans. Acta Derm Venereol. 2015;95(7):787–791. doi: 10.2340/00015555-2083</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Nebus J, Wallo W. Safety and tolerance of skin protectant lotions with oatmeal in patients with diabetes. JAAD. 2008;58(2):932. doi: 10.1016/j.jaad.2007.10.312</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Pierard GE, Piérard-Franchimont C, Scheen A. Critical assessment of diabetic xerosis. Expert Opin Med Diagn. 2013;7(2):201–207. doi: 10.1517/17530059.2013.728585</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Nakahigashi K, Tanioka M, Araki E, SawatakeT, Miyachi Y, Utani A. Case of AIDS disclosed by refractory pruritic xerosis and molluscum contagiosum. J Dermatol. 2007;34(9):668–670. doi: 10.1111/j.1346-8138.2007.00355.x</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Mischo M, von Kobyletzki LB, Bründermann E, Schmidt DA, Potthoff A, Brockmeyer NH, et al. Similar appearance, different mechanisms: xerosis in HIV, atopic dermatitis and ageing. Exp Dermatol. 2014;23(6):446–448. doi: 10.1111/exd.12425</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Raghunath RS, Venables ZC, Millington GW. The menstrual cycle and the skin. Clin Exp Dermatol. 2015;40(2):111–115. doi: 10.1111/ced.12588</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Hegedus F, Mathew LM, Schwartz RA. Radiation dermatitis: an overview. Int J Dermtol. 2017;56(9):909–914. doi: 10.1111/ijd.13371</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Ke YT, Kuo CC. Effects of colloidal oatmeal lotion of symptoms of dermatologic toxicities induced by epidermal growth factor receptor inhibitors. Adv Skin Wound Care. 2017;30(1):27–34. doi: 10.1097/01.ASW.0000505611.28732.ba</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Fleckman P, Newell BD, van Steensel MA, Yan AC. Topical treatment of ichthyoses. Dermatol Ther. 2013;26(1):16–25. doi: 10.1111/j.1529-8019.2012.01526.x</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Kottner J, Kanti V, Dobos G, Hahnel E, Lichterfeld-Kottner A, Richter C, et al. The effectiveness of using a bath oil to reduce signs of dry skin: A randomized controlled pragmatic study. Int J Nurs Stud. 2017;65:17–24. doi: 10.1016/j.ijnurstu.2016.10.010</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Loden M. Effect of moisturizers on epidermal barrier function. Clin Dermatol. 2012;(30):286–296. doi: 10.1016/j.clindermatol.2011.08.015</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Cerio R, Dohil M, Jeanine D, et al. Mechanism of action and clinical benefits of colloidal oatmeal for dermatologic practice. J Drugs Dermatol. 2010;9(9):1116–1120.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Kurtz ES, Wallo W. Colloidal oatmeal: history, chemistry and clinical properties. J Drugs Dermatol. 2007;6(2):167–170.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Nebus J, Nystrand G, Schmalenberg K, Wallo W. The rapid and lasting efficacy of an oatmeal lotion in improving the moisturization and skin barrier properties of extra dry, itchy skin. JAAD. 2010;62(3):S1,AB56. doi: 10.1016/j.jaad.2009.11.605</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Nebus J, Nystrand G, Schmalenberg K, Suero M, Wallo W. Comparing the effectiveness of an oatmeal cream versus a prescription device cream in improving skin moisturization and barrier function in moderate to severe dry skin. JAAD. 2011;64(2):S1. doi: 10.1016/j.jaad.2010.09.317</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Schweiger D, Baufeld C, Drescher P, Oltrogge B, Höpfner S, Mess A, et al. Efficacy of a new tonic containing urea, lactate, polidocanol, and glycyrrhiza inflata root extract in the treatment of a dry, itchy, and subclinically inflamed scalp. Skin Pharmacol Physiol. 2013;26(2):108–118. doi: 10.1159/000348473</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Nebus J, Suero M, Warren W. A 3-week moisturization study followed by a 2-week regression phase to evaluate the efficacy of a triple oat skin protectant cream versus a ceramide cream on moderate to severe dry skin. JAAD. 2014;70(5):S1. doi: 10.1016/j.jaad.2014.01.251</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Sobhan M, Hojatin M, Vafaie SY, Ahmadimoghaddam D, Mohammadi Y, Mehrpooya M. The efficacy of colloidal oatmeal cream 1% as add-on therapy in the management of chronic irritant hand eczema: A double-blind study. Clin Cosmet Investig Dermatol. 2020;13:241–251. doi: 10.2147/CCID.S246021</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Kim HS, Hwang HJ, Seo WD, Do SH. Oat (Avena sativa L.) Sprouts Restore Skin Barrier Function by Modulating the Expression of the Epidermal Differentiation Complex in Models of Skin Irritation. Int J Mol Sci. 2023;24(24):17274. doi: 10.3390/ijms242417274</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Liu-Walsh F, Tierney NK, Hauschild J, Rush AK, Masucci J, Leo GC, et al. Prebiotic Colloidal Oat Supports the Growth of Cutaneous Commensal Bacteria Including S. epidermidis and Enhances the Production of Lactic Acid. Clin Cosmet Investig Dermatol. 2021;14:73–82. doi: 10.2147/CCID.S253386</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Reynertson KA, Garay M, Nebus J, Chon S, Kaur S, Mahmood K, et al. Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin. J Drugs Dermatol. 2015;14(1):43–48.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Варламова С.Е., Антимоник Н.Ю., Козлова Н.М., Макеев Ю.М., Бердов Б.А., Болотина Л.В., и др. Отечественный опыт профилактики и лечения проявлений кожной токсичности у пациентов мКРР, получающих ингибиторы EGFR, на примере препарата панитумумаб. Злокачественные опухоли. 2013;3:42–50 [Varlamova SE, Antimonik NYu, Kozlova NM, Makeev YuM, Berdov BA, Bolotina LV, et al. Domestic experience in the prevention and treatment of skin toxicity in mCRC patients receiving EGFR inhibitors, using the example of the drug panitumumab. Malignant Tumors. 2013;3:42–50. (In Russ.)] doi: 10.18027/2224-5057-2013-3-42-50</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Патент 269993 Российская Федерация, МПК51 A61K 39/395 A61P 17/00. Способ коррекции дерматологических реакций у онкологических больных при применении терапии ингибиторами EGFR / Ушакова Н.Д., Владимирова Л.Ю., Попова И.Л., Абрамова Н.А., Сторожакова А.Э., Тихановская Н.М.; заявитель и патентообладатель ФГБОУ «Ростовский научно-исследовательский онкологический институт» Минздрава России. № 2018125411, 10.07.2018; опубл. 30.05.2019. Бюл. № 16. [Patent 269993 Russian Federation, MPK51 A61K 39/395 A61P 17/00 Method for correcting dermatological reactions in cancer patients when using EGFR inhibitor therapy / Ushakova ND, Vladimirova LYu, Popova IL, Abramova NA , Storozhakova AE, Tikhanovskaya NM.; applicant and patent holder of the Federal State Budgetary Educational Institution “Rostov Scientific Research Oncology Institute” of the Ministry of Health of the Russian Federation. No. 2018125411, 07.10.2018; publ. 05.30.2019. Bulletin No. 16. (In Russ.)]</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Холодилова Н.А., Беляева А.С. Полиморфный дерматоз беременных: современный взгляд на проблему. Фарматека. 2022;29(8):28–31. [Kholodilova NA, Belyaeva AS. Polymorphic dermatosis of pregnant women: a modern view of the problem. Farmateka. 2022;29(8):28–31. (In Russ.)] doi: 10.18565/pharmateca.2022.8.28-31</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Камаев А.В., Трусова О.В., Бутырина У.А., Макарова И.В. Повышение эффективности лечения детей с атопическим дерматитом в результате использования комплекса эмолиентов. Российский вестник перинатологии и педиатрии. 2019;64:(3):109–117. [Kamaev AV, Trusova OV, Butyrina UA, Makarova IV. Improvement of therapy efficacy in children with atopic dermatitis due to emollient complex. Rossiyskiy Vestnik Perinatologii i Pediatrii = Russian Bulletin of Perinatology and Pediatrics. 2019;64:(3):109–117. (In Russ.)] doi: 10.21508/1027-4065-2019-64-3-109-117</mixed-citation></ref></ref-list></back></article>
