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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16765</article-id><article-id pub-id-type="doi">10.25208/vdv16765</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАУЧНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Features of psoriasis treatment with infection COVID-19</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности терапии псориаза при инфекции COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5854-5271</contrib-id><contrib-id contrib-id-type="spin">7902-5210</contrib-id><name-alternatives><name xml:lang="en"><surname>Tashkenbaeva</surname><given-names>Umida A.</given-names></name><name xml:lang="ru"><surname>Ташкенбаева</surname><given-names>Умида Алишеровна</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Associate Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>umida.tashkenbaeva@tma.uz</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4872-3649</contrib-id><contrib-id contrib-id-type="spin">6678-2162</contrib-id><name-alternatives><name xml:lang="en"><surname>Aliev</surname><given-names>Aziz Sh.</given-names></name><name xml:lang="ru"><surname>Алиев</surname><given-names>Азиз Шавкатович</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>dr.aziz.1982828282@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5261-4479</contrib-id><name-alternatives><name xml:lang="en"><surname>Usmanaliev</surname><given-names>Sanjar A.</given-names></name><name xml:lang="ru"><surname>Усманалиев</surname><given-names>Санжар Акбаралиевич</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><email>usmanaliyevsanjar@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tashkent Medical Academy</institution></aff><aff><institution xml:lang="ru">Ташкентская медицинская академия</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-06-07" publication-format="electronic"><day>07</day><month>06</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-07-11" publication-format="electronic"><day>11</day><month>07</month><year>2024</year></pub-date><volume>100</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>50</fpage><lpage>57</lpage><history><date date-type="received" iso-8601-date="2024-03-05"><day>05</day><month>03</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-05-21"><day>21</day><month>05</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Tashkenbaeva U.A., Aliev A.S., Usmanaliev S.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Ташкенбаева У.А., Алиев А.Ш., Усманалиев С.А.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Tashkenbaeva U.A., Aliev A.S., Usmanaliev S.A.</copyright-holder><copyright-holder xml:lang="ru">Ташкенбаева У.А., Алиев А.Ш., Усманалиев С.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/16765">https://vestnikdv.ru/jour/article/view/16765</self-uri><abstract xml:lang="en"><p><bold>Background.</bold> Today, one of the difficult tasks in modern dermatology is the management of patients with chronic dermatoses, including psoriasis, due to a new coronavirus infection. The general condition of the patients, as well as concomitant therapy for the underlying disease, may subsequently produce severe side effects and complicate the treatment of concomitant skin pathology in patients in this category.</p> <p><bold>Aim.</bold> The purpose of our study was to optimize the treatment of patients with psoriasis against the background of COVID-19 infection.</p> <p><bold>Methods.</bold> Our study included 34 patients with psoriasis who were hospitalized at the Zangiota Clinical Hospital, specializing in patients with COVID-19 infection from 2020 to 2022. Also, all patients were divided according to the severity of the underlying disease according to the “Temporary recommendations for the management of patients infected with COVID-19”, fifth version of 2020. The severity of the psoriatic process was assessed using the PASI index.</p> <p><bold>Results.</bold> If patients have a psoriatic process, it is more rational to use biological drugs for the treatment of COVID-19 infection due to the absence of exacerbation of the psoriatic process in dynamics.</p> <p><bold>Conclusion.</bold> Treatment of patients with COVID-19 infection with casivirimab + imdevimab showed a positive effect on the dynamics of skin elements and the absence of relapses during three months of observation. While standard therapy for coronavirus infection gives a good regression of skin elements on the 10th day of therapy, after a month there is a progression of the skin process, the appearance of itching and new elements of psoriasis.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование. </bold>На сегодняшний день одной из сложных задач в современной дерматологии является ведение пациентов с хроническими дерматозами, в том числе с псориазом, при новой коронавирусной инфекции. Общее состояние пациентов, а также сопутствующая терапия основного заболевания могут в последующем дать тяжелые побочные эффекты и усложнить лечение кожной патологии у пациентов данной категории.</p> <p><bold>Цель исследования.</bold> Оптимизировать терапию пациентов с псориазом на фоне инфекции COVID-19.</p> <p><bold>Методы.</bold> В наше исследование включено 34 пациента с псориазом, находившихся на стационарном лечении в Зангиотинской клинической больнице, которая специализировалась на пациентах с инфекцией COVID-19 в период с 2020 по 2022 г. Все пациенты разделены по степеням тяжести течения основного заболевания согласно Временным рекомендациям по ведению пациентов, инфицированных COVID-19,<bold> </bold>пятой версии от 2020 г. Оценку степени тяжести псориатического процесса проводили с помощью индекса PASI.</p> <p><bold>Результаты.</bold> При наличии у пациентов псориатического процесса более рационально использование для лечения инфекции COVID-19 биологических препаратов в связи с отсутствием в динамике обострения псориатического процесса.</p> <p><bold>Заключение. </bold>Лечение пациентов с инфекцией COVID-19 препаратами касивиримаб + имдевимаб показало положительный эффект на динамику кожных элементов и отсутствие рецидивов в течение трех месяцев наблюдений. В то же время при стандартной терапии коронавирусной инфекции отмечен хороший регресс кожных элементов на 10-е сутки терапии, однако уже через месяц наблюдается прогрессирование кожного процесса, появление зуда и новых элементов псориаза.</p></trans-abstract><kwd-group xml:lang="en"><kwd>psoriasis</kwd><kwd>COVID-19</kwd><kwd>treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>псориаз</kwd><kwd>COVID-19</kwd><kwd>лечение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>World Health Organization. COVID-19 Weekly epidemiological update — January 17, 2021. URL: https://www.who.int/docs/default-source/coronaviruse/situationreports/weekly_epidemiological_update_23.pdf?sfvrsn=6ac0778_5&amp;download=true (accessed: 19.01.2021).</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ochani R, Asad A, Yasmin F, Shaikh S, Khalid H, Batra S, et al. COVID-19 pandemic: from origins to outcomes. 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