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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16766</article-id><article-id pub-id-type="doi">10.25208/vdv16766</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Biotechnology in dermatology: present and future</article-title><trans-title-group xml:lang="ru"><trans-title>Биотехнологии в дерматовенерологии: настоящее и будущее</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7677-1544</contrib-id><contrib-id contrib-id-type="spin">8802-7325</contrib-id><name-alternatives><name xml:lang="en"><surname>Vlasova</surname><given-names>Anna V.</given-names></name><name xml:lang="ru"><surname>Власова</surname><given-names>Анна Васильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>avvla@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5756-2747</contrib-id><contrib-id contrib-id-type="spin">2613-8597</contrib-id><name-alternatives><name xml:lang="en"><surname>Martynov</surname><given-names>Andrey A.</given-names></name><name xml:lang="ru"><surname>Мартынов</surname><given-names>Андрей Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>aamart@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-5377-1739</contrib-id><name-alternatives><name xml:lang="en"><surname>Martynova</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Мартынова</surname><given-names>Мария Андреевна</given-names></name></name-alternatives><address><country country="IL">Israel</country></address><bio xml:lang="en"><p>Student</p></bio><bio xml:lang="ru"><p>студентка</p></bio><email>manmartyn@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">State Research Center of Dermatovenereology and Cosmetology</institution></aff><aff><institution xml:lang="ru">Государственный научный центр дерматовенерологии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Tel Aviv University</institution></aff><aff><institution xml:lang="ru">Тель-Авивский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-08-16" publication-format="electronic"><day>16</day><month>08</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-08-26" publication-format="electronic"><day>26</day><month>08</month><year>2024</year></pub-date><volume>100</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>31</fpage><lpage>41</lpage><history><date date-type="received" iso-8601-date="2024-02-26"><day>26</day><month>02</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-07-12"><day>12</day><month>07</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Vlasova A.V., Martynov A.A., Martynova M.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Власова А.В., Мартынов А.А., Мартынова М.А.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Vlasova A.V., Martynov A.A., Martynova M.A.</copyright-holder><copyright-holder xml:lang="ru">Власова А.В., Мартынов А.А., Мартынова М.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/16766">https://vestnikdv.ru/jour/article/view/16766</self-uri><abstract xml:lang="en"><p>One of the fastest disciplinary measures 21 century is biotechnology, which in the last decade has become a powerful tool and assistant in the diagnosis, prognosis and elimination of various diseases. The article is devoted to a description of the following sections of medical biotechnologies used in dermatology, such as gene therapy, molecular diagnostics, pharmacogenomics and genetic (tissue) engineering. The article creates the potential for the use of biotechnology in dermatology, which remains the main hope of dermatology patients and dermatologists.</p></abstract><trans-abstract xml:lang="ru"><p>Одним из самых стремительно развивающихся научных направлений в настоящее время являются биотехнологии, которые в последнее десятилетие стали мощным оружием и помощником в диагностике, прогнозе и лечении ряда заболеваний, в том числе болезней кожи. В статье подробно освещены ключевые подразделы медицинских биотехнологий, применямых в дерматовенерологии, таких как генная терапия, молекулярная диагностика, фармакогеномика и генная (тканевая) инженерия. Подчеркивается потенциал применения биотехнологий в дерматовенерологии, который остается главной надеждой больных, страдающих заболеваниями кожи и подкожной клетчатки, а также врачей-дерматовенерологов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>biotechnology</kwd><kwd>dermatovenerology</kwd><kwd>gene therapy</kwd><kwd>molecular diagnostics</kwd><kwd>pharmacogenomics</kwd><kwd>genetic engineering</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>биотехнологии</kwd><kwd>дерматовенерология</kwd><kwd>генная терапия</kwd><kwd>молекулярная диагностика</kwd><kwd>фармакогеномика</kwd><kwd>генная инженерия</kwd></kwd-group><funding-group><funding-statement xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University); State Research Center of Dermatovenereology and Cosmetology; Tel Aviv University</funding-statement><funding-statement xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова; Государственный научный центр дерматовенерологии и косметологии; Тель-Авивский университет</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Pham PV. Medical Biotechnology: Techniques and Applications. In: Omics Technologies and Bio-engineering: Towards Improving Quality of Life. Academic Press; 2018. P. 449–69. doi: 10.1016/B978-0-12-804659-3.00019-1</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bulcha JT, Wang Y, Ma H, Tai PWL, Gao G. Viral vector platforms within the gene therapy landscape. Signal Transduct Target Ther. 2021;6(1):53. doi: 10.1038/s41392-021-00487-6</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Alnasser SM. Review on mechanistic strategy of gene therapy in the treatment of disease. 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