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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16770</article-id><article-id pub-id-type="doi">10.25208/vdv16770</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАУЧНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Analysis of the consistency of doctors’ opinions in the assessment of dermatoscopic images of actinic keratosis, Bowen’s disease, keratoacanthoma and squamous cell cancer</article-title><trans-title-group xml:lang="ru"><trans-title>Анализ согласованности мнений врачей в оценке дерматоскопических изображений актинического кератоза, болезни Боуэна, кератоакантомы и плоскоклеточного рака кожи</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7535-3025</contrib-id><contrib-id contrib-id-type="spin">3431-7447</contrib-id><name-alternatives><name xml:lang="en"><surname>Mironycheva</surname><given-names>Anna M.</given-names></name><name xml:lang="ru"><surname>Миронычева</surname><given-names>Анна Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>mironychevann@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0916-0468</contrib-id><contrib-id contrib-id-type="spin">3400-9905</contrib-id><name-alternatives><name xml:lang="en"><surname>Lazukin</surname><given-names>Valery F.</given-names></name><name xml:lang="ru"><surname>Лазукин</surname><given-names>Валерий Федорович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Biol.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.б.н., доцент</p></bio><email>valery-laz@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7885-8662</contrib-id><contrib-id contrib-id-type="spin">4588-0041</contrib-id><name-alternatives><name xml:lang="en"><surname>Grishin</surname><given-names>Artem S.</given-names></name><name xml:lang="ru"><surname>Гришин</surname><given-names>Артем Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>zhest8242@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7326-7553</contrib-id><contrib-id contrib-id-type="spin">6758-5913</contrib-id><name-alternatives><name xml:lang="en"><surname>Garanina</surname><given-names>Oxana E.</given-names></name><name xml:lang="ru"><surname>Гаранина</surname><given-names>Оксана Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н, доцент</p></bio><email>oksanachekalkina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1000-9848</contrib-id><contrib-id contrib-id-type="spin">1408-3490</contrib-id><name-alternatives><name xml:lang="en"><surname>Uskova</surname><given-names>Ksenia A.</given-names></name><name xml:lang="ru"><surname>Ускова</surname><given-names>Ксения Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>k_balyasova@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-9228-7770</contrib-id><contrib-id contrib-id-type="spin">3368-8554</contrib-id><name-alternatives><name xml:lang="en"><surname>Stepanova</surname><given-names>Yana L.</given-names></name><name xml:lang="ru"><surname>Степанова</surname><given-names>Яна Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant</p></bio><bio xml:lang="ru"><p>ассистент</p></bio><email>stepanova.ya09@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-4220-1791</contrib-id><name-alternatives><name xml:lang="en"><surname>Zinoveva</surname><given-names>Elena A.</given-names></name><name xml:lang="ru"><surname>Зиновьева</surname><given-names>Елена Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>zinovyeva190@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4089-6705</contrib-id><contrib-id contrib-id-type="spin">3679-2396</contrib-id><name-alternatives><name xml:lang="en"><surname>Makarychev</surname><given-names>Ilya S.</given-names></name><name xml:lang="ru"><surname>Макарычев</surname><given-names>Илья Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>makilyaser@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-7318-5048</contrib-id><contrib-id contrib-id-type="spin">2617-6690</contrib-id><name-alternatives><name xml:lang="en"><surname>Tomilov</surname><given-names>Vyacheslav O.</given-names></name><name xml:lang="ru"><surname>Томилов</surname><given-names>Вячеслав Олегович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>viach.tomilov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-4150-9142</contrib-id><name-alternatives><name xml:lang="en"><surname>Slesareva</surname><given-names>Elena S.</given-names></name><name xml:lang="ru"><surname>Слесарева</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>Babushkinaes95@gmail.com</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-0094-8116</contrib-id><name-alternatives><name xml:lang="en"><surname>Zhdakova</surname><given-names>Ekaterina A.</given-names></name><name xml:lang="ru"><surname>Ждакова</surname><given-names>Екатерина Алексеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ezhdakova@yandex.ru</email><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1127-9040</contrib-id><name-alternatives><name xml:lang="en"><surname>Abdullaeva</surname><given-names>Leila E.</given-names></name><name xml:lang="ru"><surname>Абдуллаева</surname><given-names>Лейла Эльчин кызы</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>kapitanfreedom@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1042-8425</contrib-id><contrib-id contrib-id-type="spin">8119-2480</contrib-id><name-alternatives><name xml:lang="en"><surname>Klemenova</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Клеменова</surname><given-names>Ирина Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>iklemenova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7253-7091</contrib-id><contrib-id contrib-id-type="spin">8301-4815</contrib-id><name-alternatives><name xml:lang="en"><surname>Shlivko</surname><given-names>Irena L.</given-names></name><name xml:lang="ru"><surname>Шливко</surname><given-names>Ирена Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>irshlivko@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Privolzhsky Research Medical University</institution></aff><aff><institution xml:lang="ru">Приволжский исследовательский медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Regional Clinical Hospital named after N.A. Semashko</institution></aff><aff><institution xml:lang="ru">Нижегородская областная клиническая больница им. Н.А. Семашко</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">ROST-klinik LLC</institution></aff><aff><institution xml:lang="ru">РОСТ-клиник</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Clinic of Aesthetic Medicine LLC</institution></aff><aff><institution xml:lang="ru">Клиника Эстетической Медицины</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">RUSMED LLC</institution></aff><aff><institution xml:lang="ru">РУСМЕД</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-06-14" publication-format="electronic"><day>14</day><month>06</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-07-11" publication-format="electronic"><day>11</day><month>07</month><year>2024</year></pub-date><volume>100</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>26</fpage><lpage>36</lpage><history><date date-type="received" iso-8601-date="2024-03-07"><day>07</day><month>03</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-05-21"><day>21</day><month>05</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Mironycheva A.M., Lazukin V.F., Grishin A.S., Garanina O.E., Uskova K.A., Stepanova Y.L., Zinoveva E.A., Makarychev I.S., Tomilov V.O., Slesareva E.S., Zhdakova E.A., Abdullaeva L.E., Klemenova I.A., Shlivko I.L.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Миронычева А.М., Лазукин В.Ф., Гришин А.С., Гаранина О.Е., Ускова К.А., Степанова Я.Л., Зиновьева Е.А., Макарычев И.С., Томилов В.О., Слесарева Е.С., Ждакова Е.А., Абдуллаева Л.Э., Клеменова И.А., Шливко И.Л.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Mironycheva A.M., Lazukin V.F., Grishin A.S., Garanina O.E., Uskova K.A., Stepanova Y.L., Zinoveva E.A., Makarychev I.S., Tomilov V.O., Slesareva E.S., Zhdakova E.A., Abdullaeva L.E., Klemenova I.A., Shlivko I.L.</copyright-holder><copyright-holder xml:lang="ru">Миронычева А.М., Лазукин В.Ф., Гришин А.С., Гаранина О.Е., Ускова К.А., Степанова Я.Л., Зиновьева Е.А., Макарычев И.С., Томилов В.О., Слесарева Е.С., Ждакова Е.А., Абдуллаева Л.Э., Клеменова И.А., Шливко И.Л.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/16770">https://vestnikdv.ru/jour/article/view/16770</self-uri><abstract xml:lang="en"><p><bold>Background. </bold>Squamous cell skin cancer (SCSC) is the most dangerous tumor of all non-melanocytic skin neoplasms due to its aggressive course with destructive growth and frequent metastasis. Another characteristic feature of SCSC is the presence of precancerous conditions such as actinic keratosis, arsenic keratosis and PUVA-keratosis. In the gradual increase in the degree of keratinocyte dysplasia to the development of invasive forms of skin malignancies, the following continuum of diseases can be distinguished: actinic keratosis — Bowen’s disease — keratoacanthoma — SCSC. Dermatoscopic signs of each of the listed nosologies can also occur in other diseases of this chain, which can complicate diagnosis and lead to erroneous patient management tactics.</p> <p><bold>Aim.</bold> To determine the consistency of dermatologists’ opinions in assessing dermatoscopic images of actinic keratosis, Bowen’s disease, keratoacanthoma and SCSC, depending on work experience.</p> <p><bold>Methods.</bold><italic> </italic>The study was conducted on the basis of the Scientific and Practical Center for the Diagnosis and Treatment of Skin Tumors of the Federal State Budgetary Educational Institution “PIMU” of the Ministry of Health of the Russian Federation. Based on the literature data, we compiled a generalized list of possible dermatoscopic signs of actinic keratosis, Bowen’s disease, keratoacanthoma, SCSC and analyzed dermatoscopic images of 85 elements of actinic keratosis, 28 — of Bowen’s disease, 10 — of keratoacanthoma and 24 — of SCSC. 10 dermatovenerologists participated in the study, half of whom (Group 1) had experience in the field of dermatoscopy for more than 4 years, and the other half (Group 2) — for less than 4 years.</p> <p><bold>Results.</bold> The study reveals statistically significant deviations in the frequencies of dermatoscopic signs between the two groups of specialists when analyzing images of actinic keratosis and Bowen’s disease. Differences in the frequency of detection of keratoacanthoma and SCSC signs between specialists with more than 4 years of experience in the field of dermatoscopy and less than 4 years’ experience have not been found.</p> <p><bold>Conclusion. </bold>Taking into account the average number of signs, the statistically justified result of the analysis is the inference that the average group frequencies in Group 1 and Group 2 are equal. The conclusion is that the opinions of specialists in the field of dermatoscopy are highly consistent, regardless of work experience. This indicates the high diagnostic value of the method, despite its subjective nature.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование. </bold>Плоскоклеточный рак кожи (ПКРК) является наиболее опасной опухолью из всех немеланоцитарных новообразований кожи из-за агрессивного течения с деструктивным ростом и частым метастазированием. Другая характерная черта ПКРК — наличие предопухолевых состояний, таких как актинический кератоз, мышьяковый кератоз и ПУВА-кератоз. В постепенном увеличении степени дисплазии кератиноцитов до развития инвазивных форм злокачественных новообразований кожи можно выделить следующий континуум заболеваний: актинический кератоз — болезнь Боуэна — кератоакантома — ПКРК. Дерматоскопические признаки каждой перечисленной нозологии могут встречаться и при других заболеваниях данной цепи, что может затруднять диагностику и приводить к ошибочной тактике ведения пациентов.</p> <p><bold>Цель исследования. </bold>Определить согласованность мнений врачей-дерматологов в оценке дерматоскопических изображений актинического кератоза, болезни Боуэна, кератоакантомы и ПКРК в зависимости от опыта работы.</p> <p><bold>Методы.</bold> Исследование проводилось на базе Научно-практического центра диагностики и лечения опухолей кожи ФГБОУ ВО «ПИМУ» Минздрава России. На основании данных литературы составлен обобщенный список возможных дерматоскопических признаков актинического кератоза, болезни Боуэна, кератоакантомы, ПКРК и проведен анализ дерматоскопических изображений 85 элементов актинического кератоза, 28 — болезни Боуэна, 10 — кератоакантомы и 24 — ПКРК. Участие в исследовании приняли 10 врачей-дерматовенерологов, половина из которых обладала опытом в области дерматоскопии более 4 лет (группа 1), а другая половина — менее 4 лет (группа 2).</p> <p><bold>Результаты.</bold> Обнаружены статистически значимые отклонения величин частот выявления дерматоскопических признаков между двумя группами специалистов при анализе изображений актинического кератоза и болезни Боуэна. Различия в частоте выявления признаков актинического кератоза и ПКРК между специалистами со стажем работы в области дерматоскопии более и менее 4 лет не обнаружены.</p> <p><bold>Заключение. </bold>С учетом среднего количества признаков статистически обоснованным результатом анализа является заключение о равенстве средних групповых частот в группах 1 и 2. Получен вывод о высокой согласованности мнений специалистов в области дерматоскопии вне зависимости от опыта работы. Это свидетельствует о высокой диагностической ценности метода, несмотря на его субъективный характер.</p></trans-abstract><kwd-group xml:lang="en"><kwd>dermatoscopy</kwd><kwd>squamous cell skin cancer</kwd><kwd>Bowen’s disease</kwd><kwd>keratoacanthoma</kwd><kwd>actinic keratosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дерматоскопия</kwd><kwd>плоскоклеточный рак кожи</kwd><kwd>болезнь Боуэна</kwd><kwd>кератоакантома</kwd><kwd>актинический кератоз</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>WHO Classification of Skin Tumours (WHO Classification of Tumours). 4th ed. Vol. 11. Eds. Elder DE, Massi D, Scolyer RA, Willemze R. WHO; 2018.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Злокачественные новообразования в России в 2019 году (заболеваемость и смертность) / под ред. А.Д. Каприна, В.В. Старинского, А.О. Шахзадовой. — М.: МНИОИ им. П.А. 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