Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov1683510.25208/vdv16835REVIEWSОБЗОР ЛИТЕРАТУРЫResearch ArticlePhototherapy in treatment of rare dermatosesМетоды фототерапии в лечении редких дерматозовhttps://orcid.org/0000-0003-2545-21298930-4073ZhilovaMarianna B.ЖиловаМарьянна Борисовна
Russian Federation

MD, Dr. Sci. (Med.)

д.м.н.

zhilova@cnikvi.ruState Research Center of Dermatovenereology and CosmetologyГосударственный научный центр дерматовенерологии и косметологии2711202415122024100622290910202419112024Copyright ©; 2024, Marianna B. ZhilovaCopyright ©; 2024, Жилова М.Б.2024Marianna B. ZhilovaЖилова М.Б.https://creativecommons.org/licenses/by-nc/4.0https://vestnikdv.ru/jour/article/view/16835

The review presents current data on the mechanisms of action of phototherapy methods in dermatology (UVB-311 therapy, PUVA-therapy, UVA-1 therapy). They are realized in providing antiproliferative, immunomodulatory, antifibrotic, antipruritic, antimicrobial effects on pathological processes in the skin. The similarities and differences of the effects on cellular structures of different spectral ranges are described. The literature data on the effectiveness of phototherapy methods in rare nosological forms of skin diseases, including dermatoses with keratinization disorders, connective tissue diseases, vascular malformations, erythematous conditions based on a variety of therapeutic mechanisms are presented.

В обзоре представлены современные данные о механизмах действия методов фототерапии в дерматологии (УФВ-311 терапии, ПУВА-терапии, УФА-1 терапии). Они реализуются в оказании антипролиферативного, иммуномодулирующего, антифиброзного, противозудного, антимикробного эффектов на патологические процессы кожи. Описаны сходство и различия воздействия на клеточные структуры разных спектральных диапазонов. С учетом многообразия механизмов терапевтического влияния представлены данные литературы об эффективности методов фототерапии при редких нозологических формах заболеваний кожи, включая дерматозы с нарушением кератинизации, заболевания соединительной ткани, сосудистые мальформации, эритематозные состояния.

phototherapymechanisms of actionPUVA-therapyNB-UVВUVA-1 therapyrare skin diseasesфототерапиямеханизмы действияПУВА-терапияУФВ-311 терапияУФА-1 терапияредкие заболевания кожиThe article is prepared and published as a part of the state task of State Research Center of Dermatovenereology and Cosmetology, Ministry of Healthcare of the Russian Federation No. 056-00002-23-00 for 2024 on the topic: “Development of a medical device for phototherapy of dermatoses and T-cell lymphomas of the skin”.Статья подготовлена и опубликована в рамках выполнения государственного задания ФГБУ «ГНЦДК» Минздрава России № 056-00002-23-00 на 2024 г. по теме: «Разработка изделия медицинского назначения для фототерапии дерматозов и Т-клеточных лимфом кожи».Torres AE, Lyons AB, Hamzavi IH, Lim HW. Role of phototherapy in the era of biologics. J Am Acad Dermatol. 2021;84(2):479–485. doi: 10.1016/j.jaad.2020.04.095Inzinger M, Heschl B, Weger W, Hofer A, Legat FJ, Gruber-Wackernagel A, et al. 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