Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov16910.25208/0042-4609-2015-91-4-113-118CLINICAL PRACTICE GUIDELINESКЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИTherapy of acne: azelaic acid and basic careТерапия акне: азелаиновая кислота и базовый уходMonakhovK. N.МонаховК. Н.
Russian Federation
knmonakhov@mail.ruDombrovskayaD. K.ДомбровскаяД. К.
Russian Federation
Pavlov State Medical University of St. PeterburgГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава России2408201591411311824082017Copyright ©; 2015, Monakhov K.N., Dombrovskaya D.K.Copyright ©; 2015, Монахов К.Н., Домбровская Д.К.2015Monakhov K.N., Dombrovskaya D.K.Монахов К.Н., Домбровская Д.К.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/169

The review covers current concepts of the pathogenesis of acne. It presents the data of international and Russian clinical studies conducted to assess the efficacy and safety of drugs comprising 15% azelaic acid and used for the treatment of acne. The authors describe mechanisms of the effect of azelaic acid on major stages of the pathogenesis of acne. They substantiate the need in basic care in the treatment of acne by the example of products of the JOYSKIN line. The authors discuss the effect of different components of skin care products on the acne-prone skin.

В обзоре освещены современные представления о патогенезе акне. Изложены данные зарубежных и отечественных клинических исследований по изучению эффективности и безопасности препаратов, содержащих 15% азелаиновую кислоту, применяемых для лечения акне. Рассмотрены механизмы воздействия азелаиновой кислоты на основные звенья патогенеза акне. Обоснована необходимость базового ухода в лечении акне на примере линии средств JOYSKIN. Обсуждается влияние различных компонентов средств по уходу на кожу, склонную к акне.

акнелечениенаружная терапияазелаиновая кислотабазовый уходДжойскинАзеликacnetreatmentexternal therapyazelaic acidbasic careJoyskinAzelicDel Rosso J.Q. The Role of Skin Care as an Integral Component in the Management of Acne Vulgaris: Part 1: The Importance of Cleanser and Moisturizer Ingredients, Design, and Product Selection. J Clin Aesthet Dermatol 2013; 6 (12): 19-27.James W.D. Acne. N Engl J Med. 2005; 352: 1463-1472. doi: 10.1056/N EJ Mcp033487 James WD. Acne. N Engl J Med 2005; 352: 1463-1472.Ghodsi S.Z., Orawa H., Zouboulis C.C. Prevalence, severity, and severity risk factors of acne in high school pupils: a community-based study. J Invest Dermatol 2009; 129 (9): 2136-2141.Glad’ko V.V., Masyukova S.A., Sanakoeva E.G., Trushkin A.I. New opportunities in treatment of acne. Klin dermatol i venerol. 2008; 5: 50-56Dawson A.L., Dellavalle R.P. Acne vulgaris. BMJ 2013; 346: f2634.Matushevskaya E.V., Svirschevskaya E.V. Azelaic acid in dermatological and cosmetological practice. Klin dermatol i venerol. 2014; 5: 11- 17.Thiboutot D., Gollnick H., Bettoli V. et al. Global Alliance to Improve Outcomes in Acne. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol 2009; 60 (5): 1-50.Zeichner J.A. Evaluating and treating the adult female patient with acne. J Drugs Dermatol 2013; 12 (12): 1416-1427.Potekaev N.N. Akne i rozatsea. M.:Binom; 2007: 216. [Акне и розацеа. Под ред. Н.Н. Потекаева М.: Бином; 2007: 216.]Samtsov A.V. Akne i akneformnye dermatozy. Monografiya. M: Yutkom 2009: 288.Araviiskaya E.R., Sokolovskii E.V. Rukovodstvo po dermatokosmetologii. SPb.: Foliant; 2008: 632.Monakhov K.N., Dombrovskaya D.K. Comprensive external therapy of acne vulgaris. Vestn dermatol venerol 2012; 3: 104-106.Kim J., Ochoa M.T., Krutzik S.R. et al. Activation of Toll-like receptor 2 in acne triggers inflammatory cytokine responses. J Immunol 2002; 169: 1535-1541.Dawson A., Dellavalle R. Acne vulgaris. BMJ 2013; 8: 346. doi:10.1136/bmj.f2634Chuang H.Y., Lee C.H. Female gender and acne disease are jointly and independently associated with the risk of major depression and suicide: a national population-based study. Biomed Res Int. 2014.Goryachkina M.V., Belousova T. A. Sovremennye predstavleniya o patogeneze, klinike i terapii akne u zhenshchin. RMJ. 2012; 22 (1153)Burkhart C.N., Burkhart C.G. Microbiology's principle of biofilms as a major factor in the pathogenesis of acne vulgaris. Int J Dermatol 2003; 42 (12): 925-927.Burkhart C.G., Burkhart C.N. Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug. J Am Acad Dermatol 2007; 57 (4): 722-724.Sokolovskiy E.V. Kozhnyi zud. Akne. Urogenital'naya khlamidiinaya infektsiya. SPb.: Sotis; 1998: 68-72.Knutsen-Larson S., Dawson A.L., Dunnick C.A., Dellavalle R.P. Acne vulgaris: pathogenesis, treatment, and needs assessment. Dermatol Clin 2012; 30: 99-106.James Q. Del Rosso, Michael Gold, Maria José Rueda, Staci Brandt, Warren J. Winkelman. Efficacy, Safety, and Subject Satisfaction of a Specified Skin Care Regimen to Cleanse, Medicate, Moisturize, and Protect the Skin of Patients Under Treatment for Acne Vulgaris. J Clin Aesthet Dermatol 2015; 8 (1): 22-23.Kungurov N.V., Zil'berberg N.V., Tolstaya A.I., Kokhan M.M. Pathogenic and clinical basis for efficiency of combined therapy of patients with acne and post-acne. Lechashchii vrach. 2013; 10: 9-13.Goryachkina M.V., Belousova T.A. Combination therapy of acne in women: searching for optimum solutions. Vestn dermatovenerol i venerol. 2014; 2: 90-95Yutskovskaya Ya.A., Taran M.G., Dvoryaninova I.E. Principles of topical acne treatment in combinayion with apparatus exposures. Eksper i klin dermatokosmetol 2012; 3: 20-23Petrova K.S., Kolbina L.S. A Complex Care after Skin by Using Curative Cosmetics in Patients with Acne. Effektivnaya farmakoterapiya. 2015; 9: 10-14.Araviiskaya E.R., Sokolovskii E.V. Efficacy of skin care products for acne patients. Farmakoter v dermatovenerol. 2013; 2: 1-4.Statsenko A.V., Gorbunov Yu.G., Khairutdinov V.R., Shestopalov N.E., Antonova O.V. Experience use of azelaic acid in patients with acne. Vestn dermatol i venerol. 2014; 5: 100- 105.Shperling N.V., Vengerovskii A.I., Shperling I.A., Romanova E.V. Local treatment of chloasma in pregnant women. Vestn dermatol i venerol. 2014; 6: 162-169.Gollnick H.P., Graupe K., Zaumseil R.P. Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies. J Dtsch Dermatol Ges 2004; 2: 841-847.Yu J.S., Kim A.K. Effect of combination of taurine and azelaic acid on antimelanogenesis in murine melanoma cells. J Biomed Sci. 2010; 17 (1): 45.Jang Y.H., Lee J.Y., Kang H.Y. et al. Oestrogen and progesterone receptor expression in melasma: an immunohistochemical analysis. J Eur Acad Dermatol Venereol 2010; 24 (11): 1312-1316.Katsambas A., Antoniou C. Melasma. Classification and treatment. J Eur Acad Dermatol Venerol 1995; 4: 217-223.Bojar R.A., Cunliffe W.J., Holland K.T. Disruption of the transmembrane pH gradient - a possible mechanism for the antibacterial action of azelaic acid in Propionibacterium acnes and Staphylococcus epidermidis. J Antimicrob Che-mother 1994; 34 (3): 321-30.Kakita L.S., Lowe N.J. Azelaic acid and glycolic acid combination therapy for facial hyperpigmentation in darker-skinned patients: a clinical comparison with hydroquinone. Clin Ther 1998; 20 (5): 960-70.Mastrofrancesco A., Ottaviani M., Aspite N. et al. Azelaic acid modulates the inflammatory response in normal human keratinocytes through PPARy activation. Exp Dermatol 2010; 19 (9): 813-820.Dukhanin A.S. The current criteria for rational pharmacotherapy of acne in women. The viewpoint of a clinical pharmacologist. Klin dermatol i venerol. 2012; 2: 108-17.Stamatiadis D., Bulteau-Portois M.C., Mowszowicz I. Inhibition of 5a-reductase activity in human skin by zinc and azelaic acid. Br J Dermatol 1988; 119 (5): 627-632.Khondker L., Khan S.I. Acne vulgaris related to androgens: a review. Mymensingh Med J 2014; 23 (1): 181-185.Fluhr J.W., Degitz K. Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy. J Dtsch Dermatol Ges 2010; 8 (1): 24-30.Acne. Clinical guidelines ROdV. M: 2013.Dreno B., Foulc P., Reynaud A. et al. Effect of zinc gluconate on Dreno B., Foulc P., Reynaud A. et al. Effect of zinc gluconate on resistance to erythromycin in patients with inflammatory acne: in vitro and in vivo study. Eur J Dermatol. 2005; 15 (3): 152-155.Thiboutot D., Del Rosso J.Q. Acne Vulgaris and the Epidermal Barrier. J Clin Aesthet Dermatol. 2013; 6 (2): 18-24.Weber S.U., Thiele J.J., Han N. et al. Topical а-tocotrienol supplementation inhibits lipid peroxidation but fails to mitigate increased transepidermal water loss after benzoyl peroxide treatment of human skin. Free Radical Biology Medicine 2003; 34: 170-176.Elias P.M. Epidermal effects of retinoids: supramolecular observations and clinical implications. J Am Acad Dermatol 1986; 15 (4): 797-809.Swinyer L.J., Swinyer T.A., Britt M.R. Topical agents alone in acne. A blind assessment study. JAMA. 1980; 243 (16): 1640-1643.Lynde C. Moisturizers for the treatment of inflammatory skin conditions. J. Drugs. Dermatol 2008; 7 (11): 1038-1043.Jackson E.M. The effects of cleansing in an acne treatment regiment. Cosmet. Dermatol 2000; 12: 9. 2000; 12: 9.