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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">16904</article-id><article-id pub-id-type="doi">10.25208/vdv16904</article-id><article-id pub-id-type="edn">eynoae</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Miescher granulomatous cheilitis as a monosymptomatic variant of Melkersson–Rosenthal syndrome</article-title><trans-title-group xml:lang="ru"><trans-title>Гранулематозный хейлит Мишера как моносимптомный вариант синдрома Мелькерссона–Розенталя</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6588-1115</contrib-id><contrib-id contrib-id-type="spin">3964-7308</contrib-id><name-alternatives><name xml:lang="en"><surname>Kharchilava</surname><given-names>Maya G.</given-names></name><name xml:lang="ru"><surname>Харчилава</surname><given-names>Майя Гиоргиевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Can. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>Kharchilava1991@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1375-056X</contrib-id><contrib-id contrib-id-type="spin">3393-3256</contrib-id><name-alternatives><name xml:lang="en"><surname>Gorbunov</surname><given-names>Yuri G.</given-names></name><name xml:lang="ru"><surname>Горбунов</surname><given-names>Юрий Геннадьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Can. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>urikgor@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4374-4435</contrib-id><contrib-id contrib-id-type="spin">6386-1117</contrib-id><name-alternatives><name xml:lang="en"><surname>Belousova</surname><given-names>Irena E.</given-names></name><name xml:lang="ru"><surname>Белоусова</surname><given-names>Ирена Эдуардовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>irena.belousova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Military Medical Academy named after S.M. Kirov</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия имени С.М. Кирова</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-11-25" publication-format="electronic"><day>25</day><month>11</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-12-13" publication-format="electronic"><day>13</day><month>12</month><year>2025</year></pub-date><volume>101</volume><issue>5</issue><issue-title xml:lang="en">Vestnik dermatologii i venerologii</issue-title><issue-title xml:lang="ru">Вестник дерматологии и венерологии</issue-title><fpage>93</fpage><lpage>99</lpage><history><date date-type="received" iso-8601-date="2025-05-12"><day>12</day><month>05</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-28"><day>28</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Kharchilava M.G., Gorbunov Y.G., Belousova I.E.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Харчилава М.Г., Горбунов Ю.Г., Белоусова И.Э.</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Kharchilava M.G., Gorbunov Y.G., Belousova I.E.</copyright-holder><copyright-holder xml:lang="ru">Харчилава М.Г., Горбунов Ю.Г., Белоусова И.Э.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/16904">https://vestnikdv.ru/jour/article/view/16904</self-uri><abstract xml:lang="en"><p>Granulomatous cheilitis is a chronic swelling of one or both lips that is caused by granulomatous inflammation. This is a rare inflammatory disease that belongs to the monosymptomatic form of Melkersson–Rosenthal syndrome. To date, the etiology of this disease remains unknown, and its treatment is challenging. The article discusses a case report of a monosymptomatic variant of recurrent orofacial edema, describes the features of the observed case and efficacy of intradermal application of glucocorticosteroids and fractional photothermolysis, and provides data on the differential diagnosis of the disease. This case highlights the importance of thorough examination in the diagnosis process as the clinical presentation can be similar to many other granulomatous conditions.</p></abstract><trans-abstract xml:lang="ru"><p>Гранулематозный хейлит — хронический отек одной или обеих губ, в основе которого лежит гранулематозное воспаление. Это редкое воспалительное заболевание, которое относится к моносимптомной форме синдрома Мелькерссона–Розенталя. На сегодняшний день этиология данного заболевания остается неизвестной, и его лечение представляет сложности. В статье рассмотрен клинический случай моносимптомного варианта рецидивирующего орофациального отека, описаны особенности наблюдаемого случая и эффективность внутрикожного применения глюкокортикостероидов и фракционного фототермолиза, а также приведены данные о дифференциальной диагностике заболевания. Данный случай подчеркивает важность тщательного обследования при диагностике, поскольку клиническая картина может быть схожа со многими другими гранулематозными состояниями.</p></trans-abstract><kwd-group xml:lang="en"><kwd>case report</kwd><kwd>granulomatous cheilitis</kwd><kwd>Melkersson–Rosenthal syndrome</kwd><kwd>orofacial granulomatosis</kwd><kwd>fractional photothermolysis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>клинический случай</kwd><kwd>гранулематозный хейлит</kwd><kwd>синдром Мелькерссона–Розенталя</kwd><kwd>орофациальный гранулематоз</kwd><kwd>фракционный фототермолиз</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Banks T, Gada S. A comprehensive review of current treatments for granulomatous cheilitis. 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