Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov1693110.25208/vdv16931hbsxqtGUIDELINES FOR PRACTITIONERSВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУResearch ArticleDermoscopy in the diagnosis of cutaneous B-cell lymphomasВозможности дерматоскопии в диагностике В-клеточных лимфом кожиhttps://orcid.org/0000-0003-3805-84893604-6491KaramovaArfenya E.КарамоваАрфеня Эдуардовна
Russian Federation

MD, Cand. Sci. (Med.), Assistant Professor

к.м.н., доцент

karamova@cnikvi.ruhttps://orcid.org/0000-0002-2924-30368310-7019AulovaKseniya M.АуловаКсения Максимовна
Russian Federation
aulovaksenia@mail.ruhttps://orcid.org/0000-0003-1141-93521307-1189NefedovaMaria A.НефедоваМария Андреевна
Russian Federation
nefedova.maria.arb@gmail.comhttps://orcid.org/0009-0005-1010-58556177-4543SheklakovaMarina N.ШеклаковаМарина Николаевна
Russian Federation

MD, Cand. Sci. (Med.)

к.м.н.

shushanic-m@yandex.ruhttps://orcid.org/0000-0002-3967-91831775-9550GorenkovaLiliya G.ГоренковаЛилия Гамилевна
Russian Federation

MD, Cand. Sci. (Med.)

к.м.н.

l.aitova@mail.ruhttps://orcid.org/0000-0002-1082-86593702-8208KovriginaAlla M.КовригинаАлла Михайловна
Russian Federation

Dr. Sci. (Biol.), Professor

д.б.н., профессор

kovrigina.alla@gmail.comState Research Center of Dermatovenereology and CosmetologyГосударственный научный центр дерматовенерологии и косметологииNational Medical Research Center for HematologyНациональный медицинский исследовательский центр гематологииI.M. Sechenov First Moscow State Medical University (Sechenov University)Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)25112025131220251015Vestnik dermatologii i venerologiiВестник дерматологии и венерологии78920408202529102025Copyright ©; 2025, Karamova A.E., Aulova K.M., Nefedova M.A., Sheklakova M.N., Gorenkova L.G., Kovrigina A.M.Copyright ©; 2025, Карамова А.Э., Аулова К.М., Нефедова М.А., Шеклакова М.Н., Горенкова Л.Г., Ковригина А.М.2025Karamova A.E., Aulova K.M., Nefedova M.A., Sheklakova M.N., Gorenkova L.G., Kovrigina A.M.Карамова А.Э., Аулова К.М., Нефедова М.А., Шеклакова М.Н., Горенкова Л.Г., Ковригина А.М.https://creativecommons.org/licenses/by-nc/4.0https://vestnikdv.ru/jour/article/view/16931

The diagnosis of cutaneous B-cell lymphomas is a challenging clinical task due to nonspecific nature of the skin manifestations in this disease. Since 2015, dermatoscopy has been used as an additional research method for the diagnosis of cutaneous B-cell lymphomas. Dermatoscopy is an inexpensive, non-invasive, and painless diagnostic method that allows to quickly obtain additional information about the disease. Currently known dermatoscopic signs, taking into account clinical and history data, may suggest a diagnosis of cutaneous B-cell lymphoma. The article clearly demonstrates the possibilities of dermatoscopy in the diagnosis of cutaneous B-cell lymphomas. However, dermatoscopy cannot replace the pathomorphological and immunohistochemical study of a skin biopsy which is the “golden standard” required for the diagnosis of cutaneous B-cell lymphoma. In some cases, a molecular genetic screening is performed to determine B-cell clonality in primary marginal zone cutaneous lymphomas with a pronounced T-cell component.

Диагностика В-клеточных лимфом кожи является сложной клинической задачей в связи с неспецифичностью кожных проявлений при данной нозологии. С 2015 г. дерматоскопия используется в качестве дополнительного метода исследования для диагностики В-клеточных лимфом кожи. Дерматоскопия — недорогой, неинвазивный и безболезненный метод диагностики, позволяющий быстро получить дополнительную информацию о заболевании. Известные в настоящее время дерматоскопические признаки с учетом клинико-анамнестических данных могут указывать на диагноз В-клеточной лимфомы кожи. В статье наглядно продемонстрированы возможности дерматоскопии в диагностике В-клеточных лимфом кожи. Тем не менее дерматоскопия не способна заменить патоморфологическое и иммуногистохимическое исследования биоптата кожи, которые являются «золотым стандартом», необходимым для установления диагноза В-клеточной лимфомы кожи. В ряде случаев при первичных кожных лимфомах из клеток маргинальной зоны, сопровождающихся выраженным Т-клеточным компонентом, дополнительно проводится молекулярно-генетическое исследование для определения В-клеточной клональности.

dermatoscopyB-cell lymphomacase reportpathomorphologyimmunohistochemistryдерматоскопияВ-клеточная лимфомаклинический случайиммуногистохимияпатоморфологияThe manuscript was prepared and published in fulfilment of State Order of the State Research Center of Dermatovenereology and Cosmetology of the Ministry of Health of the Russian Federation No. 056-00005-25-00 for 2025 and the scheduled period of 2026 and 2027.Рукопись подготовлена и опубликована в рамках выполнения государственного задания ФГБУ «ГНЦДК» Минздрава России № 056-00005-25-00 на 2025 г. и на плановый период 2026 и 2027 гг.Willemze R, Cerroni L, Kempf W, Berti E, Facchetti F, Swerdlow SH, et al. The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas. Blood. 2019;133(16):1703–1714. doi: 10.1182/blood-2018-11-881268Mascolo M, Piccolo V, Argenziano G, Costa C, Lo Presti M, De Rosa G, et al. Dermoscopy Pattern, Histopathology and Immunophenotype of Primary Cutaneous B-Cell Lymphoma Presenting as a Solitary Skin Nodule. Dermatology. 2015;232(2):203–207. doi: 10.1159/000442251Куклин И.А., Кохан М.М., Демидов С.М. Первичные лимфомы кожи. Лечащий врач. 2018;4:27–29. [Kuklin IA, Kohan MM, Demidov SM. Primary skin lymphomas. Attending Physician. 2018;4:27–29. (In Russ.)]Ciolfi C, Tartaglia J, Sernicola A, Alaibac M. Clinician’s perspective on the diagnosis of primary cutaneous B-cell lymphoma. Dermatol Reports. 2023;16(Suppl 2):9723. doi: 10.4081/dr.2023.9723Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHO–EORTC classification for cutaneous lymphomas. Blood. 2005;105(10):3768–85. doi: 10.1182/blood-2004-09-3502WHO Classification of Tumours Editorial Board. Haematolymphoid Tumours. 5th Ed. Vol. 11. Lyon: IARC Press; 2024. 958 p.Geller S, Marghoob AA, Scope A, Braun RP, Myskowski PL. Dermoscopy and the diagnosis of primary cutaneous B-cell lymphoma. J Eur Acad Dermatol Venereol. 2018;32(1):53–56. doi: 10.1111/jdv.14549Елькин В.Д., Митрюковский Л.С., Лысов А.Ю. Практическая дерматоонкология: иллюстрированное справочное руководство по опухолям кожи, опухолеподобным заболеваниям и связанным с ними синдромам. М.: Практическая медицина, 2014. С. 212–219. [El’kin VD, Mitrjukovskij LS, Lysov AJ. Practical dermato-oncology: illustrated reference guide to skin tumors, tumor-like diseases and changes with them syndromes. Moscow: Prakticheskaja medicina; 2014. P. 212–219. (In Russ.)]Goyal A, LeBlanc RE, Carter JB. Cutaneous B-Cell Lymphoma. Hematol Oncol Clin North Am. 2019;33(1):149–161. doi: 10.1016/j.hoc.2018.08.006Bombonato C, Pampena R, Lallas A, Giovanni P, Longo C. Dermoscopy of Lymphomas and Pseudolymphomas. Dermatol Clin. 2018;36(4):377–388. doi: 10.1016/j.det.2018.05.005Dobos G, Miladi M, Michel L, Ram-Wolff C, Battistella M, Bagot M, et al. Recent advances on cutaneous lymphoma epidemiology. Presse Med. 2022;51(1):104108. doi: 10.1016/j.lpm.2022.104108Белоусова И.Э., Казаков Д.В., Самцов А.В. Лимфопролиферативные заболевания кожи. Клиника и диагностика. М.: ГЭОТАР-Медиа; 2022. С. 157–235. [Belousova IЕ, Kazakov DV, Samcov AV. Limfoproliferativnye zabolevananija kozhi. Klinika i diagnostika. Moscow: GEOTAR-Media; 2022. S. 157–235. (In Russ.)] doi: 10.33029/9704-6541-7-LYM-2022-1-272Suárez AL, Pulitzer M, Horwitz S, Moskowitz A, Querfeld C, Myskowski PL. Primary cutaneous B-cell lymphomas: part I. Clinical features, diagnosis, and classification. J Am Acad Dermatol. 2013;69(3):329.e1–13. doi: 10.1016/j.jaad.2013.06.012Massone C, Fink-Puches R, Laimer M, Rütten A, Vale E, Cerroni L. Miliary and agminated-type primary cutaneous follicle center lymphoma: report of 18 cases. J Am Acad Dermatol. 2011;65(4):749–755. doi: 10.1016/j.jaad.2010.07.035Barzilai A, Feuerman H, Quaglino P, David M, Feinmesser M, Halpern M, et al. Cutaneous B-cell neoplasms mimicking granulomatous rosacea or rhinophyma. Arch Dermatol. 2012l;148(7):824–831. doi: 10.1001/archdermatol.2011.3575Behera B, Palit A, Nayak AK, Panigrahi A, Mishra P, Sethy M. Clinico-Dermoscopic-Pathological Features of a Rare Case of Locally Invasive Multifocal Primary Cutaneous Diffuse Large B Cell Lymphoma-Leg Type Over the Face and Scalp. Indian J Dermatol. 2022;67(3):283–286. doi: 10.4103/ijd.IJD_783_20Koizumi S, Togawa Y, Saeki Y, Shimizu R, Nakano M. A case of cutaneous variant of intravascular large B-cell lymphoma in which dermoscopy revealed telangiectasias associated with erythematous induration. Dermatol Reports. 2023;16(1):9731. doi: 10.4081/dr.2023.9731Llamas-Velasco M, Held L, Gold R, Paredes B. Dermoscopy of primary cutaneous intravascular large B-cell lymphoma. Clin Exp Dermatol. 2020;45(2):269–272. doi: 10.1111/ced.14073Röglin J, Böer A. Skin manifestations of intravascular lymphoma mimic inflammatory diseases of the skin. Br J Dermatol. 2007;157(1):16–25. doi: 10.1111/j.1365-2133.2007.07954.xYanagihara S, Oiso N, Ohyama Y, Masaie H, Matsumura I, Kawada A. Usefulness of dermoscopy-aided skin biopsy for clinically recognizable intravascular large B-cell lymphoma: prediction of histopathological localization of occlusive vessels based on dermoscopic findings. Eur J Dermatol. 2020. doi: 10.1684/ejd.2020.3721Moustaide K, Gallouj S, Niema A, Mernissi FZ. Are there any dermoscopic signs of primary cutaneous follicular center B-cell lymphoma. Int J Cancer Stud Res. 2016;5(1):93–95. doi: 10.19070/2167-9118-1600016Piccolo V, Mascolo M, Russo T, Staibano S, Argenziano G. Dermoscopy of primary cutaneous B-cell lymphoma (PCBCL). J Am Acad Dermatol. 2016;75(4):e137–e139. doi: 10.1016/j.jaad.2016.02.1217Mascolo M, Pagliuca F, Costa C, Scalvenzi M. Deceitful clustered papules on the scalp of a middle-aged woman. Dermatol Pract Concept. 2017;7(1):67–69. doi: 10.5826/dpc.0701a14Ghahramani GK, Goetz KE, Liu V. Dermoscopic characterization of cutaneous lymphomas: a pilot survey. Int J Dermatol. 2018;57(3):339–343. doi: 10.1111/ijd.13860Rodríguez-Lomba E, Lozano-Masdemont B, Avilés-Izquierdo JA. Slow-Growing Salmon-Pink Nodule on the Buttock. Actas Dermosifiliogr (Engl Ed). 2019;110(9):763–764. doi: 10.1016/j.ad.2018.03.024Kiyohara T, Makimura K, Nakamaru S, Miyamoto M, Shijimaya T, Nagano N, et al. B-cell lymphoblastic leukemia/lymphoma in infants: Report of two cases on the face. J Dermatol. 2019;46(7):e255-e256. doi: 10.1111/1346-8138.14799Biondo G, Sola S, Pastorino C, Massone C. Salmon-Colored and White Areas on Dermoscopy as Supportive Findings in the Diagnosis of Primary Cutaneous Marginal Zone Lymphoma. Dermatol Pract Concept. 2019;9(1):63–66. doi: 10.5826/dpc.0901a14Hoesly PM, Sluzevich JC, Cappel MA. Dermoscopy of Primary Cutaneous B-cell Lymphoma. Indian Dermatol Online J. 2019;10(2):208–209. doi: 10.4103/idoj.IDOJ_39_18Navarrete-Dechent C, Del Puerto C, Abarzúa-Araya, Molgó M, Geller S, Andreani S, et al. Dermoscopy of primary cutaneous B- and T-cell lymphomas and pseudolymphomas presenting as solitary nodules and tumors: a case-control study with histopathologic correlation. Int J Dermatol. 2019;58(11):1270–1276. doi: 10.1111/ijd.14590Miyabe C, Nomura J, Ikeda T, Takahashi K, Kawakami T. Skin biopsies using dermoscopy for earlier diagnosis of intravascular large B-cell lymphoma. J Dermatol. 2020;47(7):e276–e278. doi: 10.1111/1346-8138.15350Janowska A, Fidanzi C, Granieri G, Iannone M, Bonadio AG. An unusual presentation of primary cutaneous follicle center lymphoma. Exp Oncol. 2021;43(4):376–378. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-4.17026Conforti C, Giuffrida R, Dri A, Zalaudek I, Di Meo N. Yellow Plugs: An Additional Dermoscopic Criterion in the Diagnosis of Primary Cutaneous B-Cell Lymphoma. Dermatol Pract Concept. 2022;12(1):e2022006. doi: 10.5826/dpc.1201a06Errichetti E, Geller S, Zalaudek I, Longo C, Kyrgidis A, Akay BN, et al. Dermatoscopy of nodular/plaque-type primary cutaneous T- and B-cell lymphomas: A retrospective comparative study with pseudolymphomas and tumoral/inflammatory mimickers by the International Dermoscopy Society. J Am Acad Dermatol. 2022;86(4):774–781. doi: 10.1016/j.jaad.2021.10.020Laghi A, Lee C, Witkowski A, Hsu M, Pellacani G, Ludzik J. The role of dermatoscopy and reflectance confocal microscopy in the assessment of relapsing secondary cutaneous follicular B-cell lymphoma. JAAD Case Rep. 2022;24:91–93. doi: 10.1016/j.jdcr.2022.03.035Zalaudek I, Kreusch J, Giacomel J, Ferrara G, Catricalà C, Argenziano G. How to diagnose nonpigmented skin tumors: a review of vascular structures seen with dermoscopy: part I. Melanocytic skin tumors. J Am Acad Dermatol. 2010;63(3):361–374. doi: 10.1016/j.jaad.2009.11.698Sławińska M, Sokołowska-Wojdyło M, Olszewska B, Nowicki RJ, Sobjanek M, Zalaudek I. Dermoscopic and trichoscopic features of primary cutaneous lymphomas — systematic review. J Eur Acad Dermatol Venereol. 2021;35(7):1470–1484. doi: 10.1111/jdv.17219Pileri A, Grandi V, Agostinelli C, Santucci M, Lastrucci I, Guglielmo A, et al. BCL-2 expression in primary cutaneous follicle center lymphoma is associated with a higher risk of cutaneous relapses: A study of 126 cases. J Eur Acad Dermatol Venereol. 2022;36(10):e811–e813. doi: 10.1111/jdv.18287Zhou XA, Yang J, Ringbloom KG, Martinez-Escala ME, Stevenson KE, Wenzel AT, et al. Genomic landscape of cutaneous follicular lymphomas reveals 2 subgroups with clinically predictive molecular features. Blood Adv. 2021;5(3):649–661. doi: 10.1182/bloodadvances.2020002469