Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov1693910.25208/vdv16939xhyyjeREVIEWSОБЗОР ЛИТЕРАТУРЫReview ArticleHypertrophic scars: modern concepts of prevention and treatmentГипертрофические рубцы: современные представления о профилактике и леченииhttps://orcid.org/0000-0002-3651-47033822-8576BorzykhOlga B.БорзыхОльга Борисовна
Russian Federation

MD, Dr. Sci. (Med.)

д.м.н.

kurumchina@mail.ruhttps://orcid.org/0000-0003-0510-10222091-7363KarpovaElena I.КарповаЕлена Ивановна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

elena-karpova@inbox.ruhttps://orcid.org/0000-0002-8493-00583531-2179PetrovaMarina M.ПетроваМарина Михайловна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

stk@yandex.ruhttps://orcid.org/0000-0002-2840-837X6517-0279ShnayderNatalia A.ШнайдерНаталья Алексеевна
Russian Federation

MD, Dr. Sci. (Med.), Professor

д.м.н., профессор

NASchnaider@yandex.ruhttps://orcid.org/0009-0001-4549-77491980-4389DanilovaSvetlana V.ДаниловаСветлана Витальевна
Russian Federation

MD, Cand. Sci. (Med.)

к.м.н.

danilovamezo@mail.ruPlastic Surgery and Cosmetology Clinic “Doctor Albrecht” (LLC Artis)Клиника пластической хирургии и косметологии «Доктор Альбрехт» (ООО «Артис»)Pirogov Russian National Research Medical University (Pirogov Medical University)Российский национальный исследовательский медицинский университет имени Н.И. ПироговаProf. V.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityКрасноярский государственный медицинский университет имени профессора В.Ф. Войно-ЯсенецкогоBekhterev National Medical Research Center of Psychiatry and NeurologyНациональный медицинский исследовательский центр психиатрии и неврологии им. В.М. БехтереваGalaktika ClinicКлиника «Галактика»1501202606022026101646591409202510122025Copyright ©; 2026, Borzykh O.B., Karpova E.I., Petrova M.M., Shnayder N.A., Danilova S.V.Copyright ©; 2026, Борзых О.Б., Карпова Е.И., Петрова М.М., Шнайдер Н.А., Данилова С.В.2026Borzykh O.B., Karpova E.I., Petrova M.M., Shnayder N.A., Danilova S.V.Борзых О.Б., Карпова Е.И., Петрова М.М., Шнайдер Н.А., Данилова С.В.https://creativecommons.org/licenses/by-nc/4.0https://vestnikdv.ru/jour/article/view/16939

Despite a large number of studies, the problem of impaired wound healing, in particular hypertrophic scars, remains relevant. Currently, there is no “gold” standard for the management of patients with hypertrophic scars. The purpose of this work was to analyze modern methods of prevention and treatment of hypertrophic scars, in terms of pathogenetic aspects, advantages and disadvantages. The review article includes systematic reviews, original research, and clinical cases describing the prevention and treatment of hypertrophic scars. The search was conducted for the key terms “hypertrophic scar”, “scar-free healing”, “therapeutic strategic”, and “wound healing” in the bibliographic databases PubMed, Scopus, and eLibrary. Articles with the highest citation index were selected from the data obtained. A total of 3,861 titles, 1,484 full articles were reviewed, and 139 articles are included in this review. An analysis of numerous scientific papers has provided a deep understanding of modern strategies for the prevention and treatment of hypertrophic scars. In this article, all the presented methods can be divided into 2 groups: methods that directly affect the blocking of extracellular matrix overproduction and methods that improve regeneration, including tissues around the wound. The latter, according to a few authors, are a promising area of wound healing, as they reduce the overall healing time, thereby contributing to a noticeable aesthetic improvement in the appearance of scars.

Несмотря на большое количество исследований, проблема нарушения заживления ран, в частности гипертрофических рубцов, остается актуальной. В настоящее время нет «золотого стандарта» ведения пациентов с гипертрофическими рубцами. Цель настоящей работы — анализ современных методов профилактики и лечения гипертрофических рубцов с точки зрения патогенетических аспектов, преимуществ и недостатков. В обзорную статью включены систематические обзоры, оригинальные исследования и клинические случаи, описывающие профилактику и лечение гипертрофических рубцов. Поиск был проведен по ключевым терминам «гипертрофический рубец» («hypertrophic scar»), «безрубцовое заживление» («scar-free healing»), «лечение» («therapeutic strategic»), «заживление раны» («wound healing») в библиографических базах PubMed, Scopus, eLIBRARY. Из полученных данных отобраны статьи с наибольшим индексом цитирования. Всего было просмотрено 3861 название, 1484 полных статей, включено в настоящий обзор 139 статей. Анализ множества научных работ дал понимание современных стратегий профилактики и лечения гипертрофических рубцов. Все представленные методы можно разделить на две группы: методы, влияющие непосредственно на блокирование сверхпродукции внеклеточного матрикса, и методы, улучшающие регенерацию, в том числе тканей вокруг раны. Последние, по мнению ряда авторов, являются перспективным направлением заживления ран, так как они сокращают общее время заживления и тем самым способствуют заметному эстетическому улучшению внешнего вида рубцов.

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