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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">17032</article-id><article-id pub-id-type="doi">10.25208/vdv17032</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL PRACTICE GUIDELINES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">EVOLUTION OF THERAPEUTIC APPROACHES TO ATOPIC DERMATITIS: A COMPARATIVE ANALYSIS OF CURRENT CLINICAL GUIDELINES</article-title><trans-title-group xml:lang="ru"><trans-title>ЭВОЛЮЦИЯ ТЕРАПЕВТИЧЕСКИХ ПОДХОДОВ К АТОПИЧЕСКОМУ ДЕРМАТИТУ: СРАВНИТЕЛЬНЫЙ АНАЛИЗ СОВРЕМЕННЫХ КЛИНИЧЕСКИХ РЕКОМЕНДАЦИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7689-8350</contrib-id><contrib-id contrib-id-type="spin">6938-4768</contrib-id><name-alternatives><name xml:lang="en"><surname>Drozhdina</surname><given-names>Marianna B.</given-names></name><name xml:lang="ru"><surname>Дрождина</surname><given-names>Марианна Борисовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Professor, PhD, MD, Professor of the department od dermatovenereology and cosmetology of Kirov state medical University</p></bio><bio xml:lang="ru"><p>Доцент, кандидат медицинских наук, доцент кафедры дерматовенерологии и косметологии Кировского ГМУ</p></bio><email>drozhdina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-8241-0906</contrib-id><contrib-id contrib-id-type="spin">4614-1812</contrib-id><name-alternatives><name xml:lang="en"><surname>Suslova</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Суслова</surname><given-names>Елена Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, MD</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>ev780464@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2306-1423</contrib-id><name-alternatives><name xml:lang="en"><surname>Lazviashvili</surname><given-names>Varvara Andreevna</given-names></name><name xml:lang="ru"><surname>Лазвиашвили</surname><given-names>Варвара Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate student</p></bio><bio xml:lang="ru"><p>Аспирант кафедры дерматовенерологии и косметологии</p></bio><email>lazviashvili.va@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-1019-498X</contrib-id><name-alternatives><name xml:lang="en"><surname>Zapivakhina</surname><given-names>Lada A.</given-names></name><name xml:lang="ru"><surname>Запивахина</surname><given-names>Лада Алексеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student</p></bio><bio xml:lang="ru"><p>Студент</p></bio><email>zapivakhinavlada@yandex.ru</email><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-4040-3012</contrib-id><name-alternatives><name xml:lang="en"><surname>Dekusar</surname><given-names>Nikita S.</given-names></name><name xml:lang="ru"><surname>Декусар</surname><given-names>Никита Станиславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student</p></bio><bio xml:lang="ru"><p>Студент</p></bio><email>dekusar05@mail.ru</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal State Budgetary Educational Institution of Higher Education «Kirov state medical University» of the Ministry of Healthcare, Kirov, Russia Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of Russia, Moscow, Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО Кировский ГМУ Минздрава России, Киров, Россия ФГБОУ ВО «Российский университет медицины» Минздрава России, г. Москва, Россия</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Limited Liability Company «Medica»</institution></aff><aff><institution xml:lang="ru">ООО «Медика», Киров, Россия</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Federal State Budgetary Educational Institution of Higher Education «Kirov state medical University» of the Ministry of Healthcare, Kirov, Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО Кировский ГМУ Минздрава России, Киров</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Federal State Budgetary Educational Institution of Higher Education «Vyatka State University» of the Ministry of Education, Kirov, Russia</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Вятский государственный университет», Киров, Россия</institution></aff></aff-alternatives><content-language>ru</content-language><pub-date date-type="preprint" publication-format="electronic" iso-8601-date="2026-09-29"><day>29</day><month>09</month><year>2026</year></pub-date><volume>102</volume><issue>4</issue><issue-title xml:lang="ru"/><history><date date-type="received" iso-8601-date="2026-08-15"><day>15</day><month>08</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-09-07"><day>07</day><month>09</month><year>2026</year></date></history><pub-history><event event-type="received"><event-desc>Received:<date date-type="received" iso-8601-date="2026-08-15"><day>15</day><month>08</month><year>2026</year></date></event-desc></event><event event-type="accepted"><event-desc>Accepted:<date date-type="accepted" iso-8601-date="2026-09-07"><day>07</day><month>09</month><year>2026</year></date></event-desc></event></pub-history><permissions><copyright-statement xml:lang="en">Copyright ©; , Drozhdina M.B., Suslova E.V., Lazviashvili V.A., Zapivakhina L.A., Dekusar N.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; , Дрождина М.Б., Суслова Е.В., Лазвиашвили В.А., Запивахина Л.А., Декусар Н.С.</copyright-statement><copyright-holder xml:lang="en">Drozhdina M.B., Suslova E.V., Lazviashvili V.A., Zapivakhina L.A., Dekusar N.S.</copyright-holder><copyright-holder xml:lang="ru">Дрождина М.Б., Суслова Е.В., Лазвиашвили В.А., Запивахина Л.А., Декусар Н.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/17032">https://vestnikdv.ru/jour/article/view/17032</self-uri><abstract xml:lang="en"><p>The treatment of atopic dermatitis (AD) has changed substantially with the advent of targeted biologics, JAK inhibitors, and novel topical agents, necessitating regular updates of clinical guidelines. This review aims to comparatively analyze AD guidelines published or updated in 2024–2025 in Japan, Canada, Korea, Europe, and Russia. All documents demonstrate a shift toward individualized therapy based on disease severity, lesion localization, itch intensity, quality of life, age, and comorbidities. Topical corticosteroids remain a cornerstone, but the role of non-steroidal agents and proactive maintenance therapy is increasingly emphasized. In moderate-to-severe AD, systemic targeted therapies have become a central component of treatment algorithms. National guidelines exhibit specific features in diagnostic approaches and the use of systemic corticosteroids, reflecting local healthcare standards.</p></abstract><trans-abstract xml:lang="ru"><p>Лечение атопического дерматита (АД) существенно изменилось с появлением таргетных биопрепаратов, ингибиторов JAK и новых топических средств, что требует актуализации клинических рекомендаций. Цель обзора — сравнительный анализ руководств по АД, опубликованных в 2024–2025 гг. в Японии, Канаде, Корее, Европе и России. Все документы демонстрируют переход к индивидуализированной терапии с учётом тяжести, локализации, зуда, качества жизни, возраста и коморбидности. Топические кортикостероиды сохраняют ключевую роль, но усиливается значение нестероидных средств и проактивной терапии. При среднетяжёлом и тяжёлом течении системные таргетные препараты становятся центральным компонентом. Национальные руководства имеют особенности в диагностике и применении системных ГКС, обусловленные местными стандартами.</p></trans-abstract><kwd-group xml:lang="en"><kwd>atopic dermatitis</kwd><kwd>clinical guidelines</kwd><kwd>biological therapy</kwd><kwd>JAK inhibitors</kwd><kwd>topical therapy</kwd><kwd>personalized medicine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>атопический дерматит</kwd><kwd>клинические рекомендации</kwd><kwd>биологическая терапия</kwd><kwd>ингибиторы JAK</kwd><kwd>топическая терапия</kwd><kwd>персонализированная медицина</kwd></kwd-group><funding-group><funding-statement xml:lang="en">Not applicable</funding-statement><funding-statement xml:lang="ru">Неприменимо</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. 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