Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov23310.25208/0042-4609-2016-92-2-110-114DRUG TREATMENT IN DERMATOVENEROLOGYФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИPH OF THE TOPICAL DRUG VEHICLE: SELECTING AN OPTIMUM VALUE AND ROLE OF THE BUFFER SYSTEMpH ОСНОВЫ ТОПИЧЕСКОГО ЛЕКАРСТВЕННОГО ПРЕПАРАТА: ВЫБОР ОПТИМАЛЬНОГО ЗНАЧЕНИЯ И РОЛЬ БУФЕРНОЙ СИСТЕМЫDukhaninA. S.ДуханинА. С.
Russian Federation
das03@rambler.ruPirogov Russian National Research Medical UniversityГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России2404201692211011424082017Copyright ©; 2016, Dukhanin A.S.Copyright ©; 2016, Духанин А.С.2016Dukhanin A.S.Духанин А.С.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/233

The following three groups of factors must be taken into consideration for selecting an optimum pH value of a topical drug: pharmaceutical, pharmacological and compatibility factors. To ensure a stable pH value, the drug vehicle comprises different buffer systems: single component and two-component ones. The optimum conditions for selecting and maintaining the vehicle pH were examined by the example of glucocorticosteroid-based topical drugs.

При выборе оптимального значения рН топического лекарственного препарата должны учитываться три группы факторов: фармацевтические, фармакологические и факторы совместимости. Для поддержания стабильного значения рН в основу препарата вводят различные буферные системы, которые разделяются на монокомпонентные и двухкомпонентные. На примере топических препаратов, содержащих глюкокортикостероиды, рассмотрены оптимальные условия выбора и поддержания рН основы.

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