Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov25210.25208/0042-4609-2016-92-4-12-19SHORT COMMUNICATIONКРАТКИЕ СООБЩЕНИЯDrug therapy of leprosyФармакотерапия лепрыKubanovA. A.КубановА. А.
Russian Federation
KaramovaA. E.КарамоваА. Э.
Russian Federation
karamova@cnikvi.ruVorontsovaA. A.ВоронцоваА. А.
Russian Federation
KalininaP. A.КалининаП. А.
Russian Federation
ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава РоссииГБОУ ДПО «Российская медицинская академия последипломного образования» Минздрава России24082016924121924082017Copyright ©; 2016, Kubanov A.A., Karamova A.E., Vorontsova A.A., Kalinina P.A.Copyright ©; 2016, Кубанов А.А., Карамова А.Э., Воронцова А.А., Калинина П.А.2016Kubanov A.A., Karamova A.E., Vorontsova A.A., Kalinina P.A.Кубанов А.А., Карамова А.Э., Воронцова А.А., Калинина П.А.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/252

Leprosy (Hansen’s disease) is a chronic granulomatous bacterial infection mainly affecting the skin and peripheral nervous system yet also involving other organs and systems as a result of a pathological process. The causative agent of leprosy - Mycobacterium leprae - is an obligate intracellular microorganism. Despite the removal of a threat of a leprosy epidemic, European countries still record outbreaks of the disease mainly among migrants coming from endemic areas. A golden standard of the treatment of leprosy is a WHO-recommended combined drug therapy comprising drugs such as dapsone, clofazimine and rifampicin. The article provides current data on the mechanisms of action, efficacy and safety of these drugs and their combined scheme of treatment obtained as a result of clinical trials. Moreover, it also reviews new regimens of the drug therapy of leprosy including those with the use of drugs from the group of fluoroquinols as well as immunotherapy of the disease.

Лепра (болезнь Хансена) - хроническая гранулематозная бактериальная инфекция, поражающая преимущественно кожные покровы и периферическую нервную систему, однако в патологический процесс также вовлекаются другие органы и системы. Возбудитель лепры - Mycobacterium leprae - это облигатный внутриклеточный микроорганизм. Несмотря на устранение угрозы эпидемии лепры, в странах Европы продолжают регистрироваться вспышки заболевания, главным образом, среди мигрантов из эндемичных очагов. «Золотым стандартом» лечения лепры является комбинированная лекарственная терапия, рекомендованная ВОЗ, которая включает такие препараты, как дапсон, клофазимин и рифампицин. Представлены современные данные о механизмах действия, эффективности и безопасности указанных препаратов и их комбинированной схемы, которые были получены в клинических испытаниях. Кроме того, рассмотрены новые режимы лекарственной терапии лепры, в том числе с применением препаратов из группы фторхинолонов, а также иммунотерапия заболевания.

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