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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">276</article-id><article-id pub-id-type="doi">10.25208/0042-4609-2016-92-5-90-95</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DRUG TREATMENT IN DERMATOVENEROLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Onychomycosis: features external therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Онихомикоз: особенности наружной терапии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zaslavsky</surname><given-names>D. V.</given-names></name><name xml:lang="ru"><surname>Заславский</surname><given-names>Д. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>venerology@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chuprov</surname><given-names>I. N.</given-names></name><name xml:lang="ru"><surname>Чупров</surname><given-names>И. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>venerology@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sidikov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Сыдиков</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>venerology@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khvedelidze</surname><given-names>M. G.</given-names></name><name xml:lang="ru"><surname>Хведелидзе</surname><given-names>М. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>venerology@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tatarskaya</surname><given-names>O. B.</given-names></name><name xml:lang="ru"><surname>Татарская</surname><given-names>О. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>venerology@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">St. Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">ФБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">State Medical University by the name I.I. Mechnikov</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Leningrad Regional Center of specialized types of medical care</institution></aff><aff><institution xml:lang="ru">Ленинградский областной центр специализированных видов медицинской помощи</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-10-24" publication-format="electronic"><day>24</day><month>10</month><year>2016</year></pub-date><volume>92</volume><issue>5</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>90</fpage><lpage>95</lpage><history><date date-type="received" iso-8601-date="2017-08-24"><day>24</day><month>08</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Zaslavsky D.V., Chuprov I.N., Sidikov A.A., Khvedelidze M.G., Tatarskaya O.B.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Заславский Д.В., Чупров И.Н., Сыдиков А.А., Хведелидзе М.Г., Татарская О.Б.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Zaslavsky D.V., Chuprov I.N., Sidikov A.A., Khvedelidze M.G., Tatarskaya O.B.</copyright-holder><copyright-holder xml:lang="ru">Заславский Д.В., Чупров И.Н., Сыдиков А.А., Хведелидзе М.Г., Татарская О.Б.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/276">https://vestnikdv.ru/jour/article/view/276</self-uri><abstract xml:lang="en"><p>Onychomycosis - one of the most frequent diseases with defeat of a nail bed, matrics and nail plate of a fungal origin. Frequency of an onychomycosis in Russia reaches 5% (to 15 million people), and practically every tenth visit of the dermatologist is connected with this pathology. Treatment of an onychomycosis still remains very difficult task. Application of varnishes, ointments with antimycotics and local agents on an oil basis has an essential shortcoming - insufficient receipt of a preparation to the center of pathological changes. It is supposed that for optimum therapy it is necessary to influence: first, from frontal and distal part of a nail, secondly, to apply aqueous-alcoholic solutions of a preparation which can freely get into subnail spaces with the phenomena of an onycholysis. For example, it has been shown highly efficient application of naftifina a hydrochloride under control of solution of the diamond green, showing diffusion distribution active ingredient to subnail space and on channels.</p></abstract><trans-abstract xml:lang="ru"><p>Онихомикоз - одно из наиболее частых заболеваний с поражением ногтевого ложа, матрикса и ногтевой пластины грибкового происхождения. Частота онихомикоза в России достигает 5% (до 15 млн человек), причем практически каждое десятое посещение дерматолога связано именно с этой патологией. Лечение онихомикоза до сих пор остается весьма непростой задачей. Применение лаков, мазей с антимикотиками и местных средств на масляной основе имеет существенный недостаток - недостаточное поступление препарата к центру патологических изменений. Предполагается, что для оптимальной терапии следует, во-первых, воздействовать с фронтально-дистальной части ногтя, во-вторых, применять водно-спиртовые растворы препарата, которые могут свободно проникать в подногтевые пространства с явлениями онихолизиса. Например, показана эффективность применения препарата нафтифина гидрохлорида под контролем раствора бриллиантового зеленого, демонстрирующего диффузное распространение действующего вещества в подногтевое пространство и по каналам.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>онихомикоз</kwd><kwd>дерматомицеты</kwd><kwd>местная терапия</kwd><kwd>onychomycosis</kwd><kwd>dermatomitsets</kwd><kwd>local therapy</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Scher R.K., Coppa L.M. Advances in the diagnosis and treatment of onychomycosis. Hosp Med 1998; 34: 11-20.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Lubeck D.P. 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