Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov29310.25208/0042-4609-2017-93-1-21-30SHORT COMMUNICATIONКРАТКИЕ СООБЩЕНИЯТіе Modern treatment of androgenetic alopeciaСовременные подходы к лечению андрогенетической алопецииKarnaukhovV. K.КарнауховВ. К.
Russian Federation
vadim-karnaukhov@mail.ruLukyanovaA. A.ЛукьяноваА. А.
Russian Federation
LukashinaM. I.ЛукашинаМ. И.
Russian Federation
VorobevaE. S.ВоробьёваЕ. С.
Russian Federation
AfanasovI. M.АфанасовИ. М.
Russian Federation
Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М. В. Ломоносова»Shkola stilistov PersonaШкола стилистов ПЕРСОНАFederal State Budget Institution of Sciences Institute of Gene Biology, Russian Academy of SciencesФГБУН «Институт биологии гена» РАНThe Russian National Research Medical University named after N.I. PirogovФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова» Минздрава РоссииOOO ”DzhiJef Grupp”ООО «ДжиЭф Групп»24022017931213024082017Copyright ©; 2017, Karnaukhov V.K., Lukyanova A.A., Lukashina M.I., Vorobeva E.S., Afanasov I.M.Copyright ©; 2017, Карнаухов В.К., Лукьянова А.А., Лукашина М.И., Воробьёва Е.С., Афанасов И.М.2017Karnaukhov V.K., Lukyanova A.A., Lukashina M.I., Vorobeva E.S., Afanasov I.M.Карнаухов В.К., Лукьянова А.А., Лукашина М.И., Воробьёва Е.С., Афанасов И.М.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/293

Androgenetic alopecia (AGA) is the most common reason for hair loss. Its frequency in Caucasian population is up to 80% in men and 42% in women. Current gold standard for AGA treatment includes minoxidil and/or finasteride. Both drugs have moderate treatment efficacy and can cause significant side effects. Minoxidil is the only option for treatment of AGA in women since finasteride has no efficacy. This review considers actual concepts of molecular mechanisms of pathogenesis and current treatment options of AGA with their limitations and shortcomings. Current state and perspectives of novel approaches to AGA treatment, potentially more effective and safe than minoxidil and finasteride, are described. The review discusses growth factors and cytokines, topical 5-alpha-reductase inhibitors, androgen receptor antagonists, prostaglandin analogs and antagonists, Wnt signaling activators and platelet-rich plasma injections.

Большинство случаев выпадения волос обусловлено андрогенетической алопецией (АГА). Для европеоидной расы вероятность появления этого заболевания достигает 80% для мужчин и 42% для женщин. Золотой стандарт лечения АГА включает миноксидил и/или финастерид. Эффективность этих препаратов умеренная, рост волос наблюдается далеко не у всех пациентов. Более того, оба средства имеют значимые побочные эффекты. Для лечения АГА у женщин может использоваться только миноксидил. В работе анализируются современные представления о молекулярных механизмах патогенеза и методах лечения АГА с их ограничениями и недостатками. Освещены перспективные подходы к лечению АГА, способные превзойти по эффективности и безопасности миноксидил и финастерид, их сегодняшнее состояние и перспективы. Обсуждаются средства на основе факторов роста и цитокинов, ингибиторы 5а-редуктазы местного нанесения, антагонисты андрогеновых рецепторов, активаторы Wnt-сигнального пути, аналоги и антагонисты простагландинов, а также процедура плазмотерапии обогащенной тромбоцитами плазмой.

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