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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">296</article-id><article-id pub-id-type="doi">10.25208/0042-4609-2017-93-1-46-50</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL CASE REPORTS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>НАБЛЮДЕНИЕ ИЗ ПРАКТИКИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Skin lesion at acute monoblastic leukemia (clinical observation)</article-title><trans-title-group xml:lang="ru"><trans-title>Поражение кожи при остром монобластном лейкозе (клиническое наблюдение)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chernova</surname><given-names>N. G.</given-names></name><name xml:lang="ru"><surname>Чернова</surname><given-names>Н. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ngchernova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sinicyna</surname><given-names>M. N.</given-names></name><name xml:lang="ru"><surname>Синицына</surname><given-names>М. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dvirnyk</surname><given-names>V. N.</given-names></name><name xml:lang="ru"><surname>Двирнык</surname><given-names>В. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kovrigina</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Ковригина</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zvonkov</surname><given-names>E. E.</given-names></name><name xml:lang="ru"><surname>Звонков</surname><given-names>Е. Е.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Parovichnikova</surname><given-names>E. N.</given-names></name><name xml:lang="ru"><surname>Паровичникова</surname><given-names>Е. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Hematological Scientific Center</institution></aff><aff><institution xml:lang="ru">ФГБУ «Гематологический научный центр» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-02-24" publication-format="electronic"><day>24</day><month>02</month><year>2017</year></pub-date><volume>93</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>46</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2017-08-24"><day>24</day><month>08</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Chernova N.G., Sinicyna M.N., Dvirnyk V.N., Kovrigina A.M., Zvonkov E.E., Parovichnikova E.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Чернова Н.Г., Синицына М.Н., Двирнык В.Н., Ковригина А.М., Звонков Е.Е., Паровичникова Е.Н.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Chernova N.G., Sinicyna M.N., Dvirnyk V.N., Kovrigina A.M., Zvonkov E.E., Parovichnikova E.N.</copyright-holder><copyright-holder xml:lang="ru">Чернова Н.Г., Синицына М.Н., Двирнык В.Н., Ковригина А.М., Звонков Е.Е., Паровичникова Е.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/296">https://vestnikdv.ru/jour/article/view/296</self-uri><abstract xml:lang="en"><p>At present diagnosis of acute leukemia does not represent any difficulties and is based on morphological and immunophenotypical bone marrow studies. The paper presents a non-standard verification algorithm of acute monoblastic leukemia in elderly female patient, with leukemic skin lesion. Morphologic and immunohistochemical studies of biopsy materials of skin, lymph node and bone marrow allow establishing a linear membership of tumor cells and promptly verifying the diagnosis of leukemia. Lack of the overall clinical examination in such cases leads to diagnostic errors and to late verification of the true diagnosis and significantly worsens the prognosis.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время диагностика острых лейкозов не представляет особых трудностей и основывается на морфологическом и иммунофенотипическом исследованиях костного мозга. Представлен нестандартный алгоритм верификации острого монобластного лейкоза у пожилой пациентки, протекающего с лейкемическим поражением кожи. Морфологическое и иммуногистохимическое исследования биоптатов кожи, лимфоузла и костного мозга позволили установить линейную принадлежность опухолевых клеток и своевременно верифицировать диагноз лейкемии. Отсутствие комплексного клинического обследования в подобных случаях приводит к диагностическим ошибкам, поздней верификации истинного диагноза и существенно ухудшает прогноз.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острый монобластный лейкоз</kwd><kwd>экстрамедуллярные очаги поражения</kwd><kwd>лейкемическое поражение кожи</kwd><kwd>acute monoblastic leukemia</kwd><kwd>extramedullar lesions</kwd><kwd>leukemic skin lesion</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Swerdlow S. H., Campo E., Harris N. L., Jaffe E. S., Pileri S. A., Stein H., Thiele J., Vardiman J. W. WHO classification of tumor of haematopoietic and lymphoid tissues. 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