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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">307</article-id><article-id pub-id-type="doi">10.25208/0042-4609-2017-93-2-45-52</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL PRACTICE GUIDELINES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Diagnosis of actinic keratosis by dermatoscopy</article-title><trans-title-group xml:lang="ru"><trans-title>Диагностика актинического кератоза методом дерматоскопии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khlebnikova</surname><given-names>A. N.</given-names></name><name xml:lang="ru"><surname>Хлебникова</surname><given-names>А. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>89160428216@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Obydenova</surname><given-names>K. V.</given-names></name><name xml:lang="ru"><surname>Обыденова</surname><given-names>К. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>89160428216@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sedova</surname><given-names>T. G.</given-names></name><name xml:lang="ru"><surname>Седова</surname><given-names>Т. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>89160428216@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Andrukhina</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Андрюхина</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>89160428216@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I. M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">MO GBUZ MONIKI im. M. F Vladimirskogo</institution></aff><aff><institution xml:lang="ru">ГБУЗ МО МОНИКИ им. М. Ф. Владимирского</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Perm State Medical University named after E. A. Wagnera (PSMU) of the Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО ПГМУ им. академика Е. А. Вагнера</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-24" publication-format="electronic"><day>24</day><month>04</month><year>2017</year></pub-date><volume>93</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>45</fpage><lpage>52</lpage><history><date date-type="received" iso-8601-date="2017-08-24"><day>24</day><month>08</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Khlebnikova A.N., Obydenova K.V., Sedova T.G., Andrukhina V.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Хлебникова А.Н., Обыденова К.В., Седова Т.Г., Андрюхина В.В.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Khlebnikova A.N., Obydenova K.V., Sedova T.G., Andrukhina V.V.</copyright-holder><copyright-holder xml:lang="ru">Хлебникова А.Н., Обыденова К.В., Седова Т.Г., Андрюхина В.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/307">https://vestnikdv.ru/jour/article/view/307</self-uri><abstract xml:lang="en"><p>Introduction: Actinic keratosis (AK) is a local introepidermal atypia of keratinocytes, formed as a result of intense and prolonged exposure to sunlight. AK lesions located on exposed areas of skin, mostly on the face, in this regard, a more relevant non-invasive diagnostic techniques, primarily dermatoscopy. Material and methods: We examined 35 patients and revealed they have 204 hearth. Results: Of the 204 lesions erythematous form was found in 160 (78, 4%) cases, keratotic - 24 (11,8%), pigmental (9.8 %). Patients with AK most private dermatoscopic signs were erythema (90,2%), vascular structures (67,65%), keratin scales (51,47%), pseudonetwork (23,04%). Discussion: Analyzing dermoscopic picture of the most common forms of AK met the characteristics for each shape. A detailed study of vascular structures allows for the differential diagnosis of cancer in situ. While AK watched point and the glomerular vessels of not more than 10% of cases, which helped to differentiate AK from cancer in situ, in which such vessels were found in 40%. Glomerular vessels are not met in our study and the points were only 2.45% of the cases. Keratotic AK was characterized in 100% of cases the presence of keratin scales. In pigment form, we revealed the dark brown streaks (80%), dark brown points (50%), brown globules (30%), dark brown blots (10%) and slate-grey dots (10%). But the gold standard for the differential diagnosis with maligna lentigo is a morphological study. Conclusion: AK has specific characteristics in treatment research, which helps to differentiate it from other benign and malignant tumors of the skin, and to diagnose it in its earliest stages without resorting to invasive procedures. Effective diagnosis of AK reduces the risk of malignant transformation and contribute to the selection of adequate and necessary treatment tactics.</p></abstract><trans-abstract xml:lang="ru"><p>Актинический кератоз (АК) является локальной внутриэпидермальной атипией кератиноцитов, образующейся вследствие интенсивного и длительного воздействия солнечных лучей. Очаги АК располагаются на открытых участках кожного покрова, в основном на лице, в связи с этим более актуальны неинвазивные методы диагностики, в первую очередь дерматоскопия. Материал и методы. Было обследовано 35 пациентов и выявлено у них 204 очага. Результаты. Среди 204 очагов эритематозная форма встречалась в 160 (78,4%) случаях, кератотическая - в 24 (11,8%), пигментная - в 20 (9,8%). У пациентов с АК наиболее частыми дерматоскопическими признаками явились эритема (90,2%), сосудистые структуры (67,65%), кератиновые чешуйки (51,47%), псевдосетка (23,04%). Обсуждение. При анализе дерматоскопической картины наиболее частых форм АК встречались характерные признаки для каждой формы. Детальное изучение сосудистых структур позволяет проводить дифференциальный диагноз с раком in situ. При АК наблюдали точечные и клубочковые сосуды не более чем в 10% случаев, что помогало дифференцировать АК от рака in situ, при котором подобные сосуды встречались в 40%. Клубочковые сосуды не встречались в нашем исследовании, а точки отмечали только в 2,45% случаев. Кератотическая форма характеризовалась в 100% случаев наличием кератиновых чешуек. При пигментной форме мы выявляли темно-коричневые прожилки (80% случаев), темно-коричневые точки (50%), коричневые глобулы (30%), темнокоричневые кляксы (10%) и шиферно-серые точки (10%). Но золотым стандартом дифференциального диагноза со злокачественным лентиго является морфологическое исследование. Заключение. АК имеет специфические признаки при дерматоскопическом исследовании, которые помогают дифференцировать его от доброкачественных и злокачественных образований кожи, а также диагностировать его на самых ранних стадиях, не прибегая к инвазивным методикам. Эффективная диагностика АК снизит риск злокачественной трансформации и будет способствовать выбору адекватной и необходимой тактики лечения.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>актинический кератоз</kwd><kwd>дерматоскопия</kwd><kwd>рак in situ</kwd><kwd>actinic keratosis</kwd><kwd>dermatoscopy</kwd><kwd>cancer in situ</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Молочков В. А., Молочков А. В. Клиническая дерматоонкология. М.: Из-во студия МДВ, 2011. 340 с., илл., табл. с. 74</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Claudia Costa, Massimiliano Scalvenzi, Fabio Ayala, Gabriella Fabbrocini, Giuseppe Monfrecola. How to treat actinic keratosis? An update. Department of Dermatology, Federico II University, Naples, Italy. J Dermatol Case Rep 2015; 2: pp 29-35.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Annabel Dodds, Alvin Chia, Stephen Shumack. 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