Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov35110.25208/0042-4609-2017-93-6-41-46Purulent Hydradenitis. Part IIRodionovA. N.fake@neicon.ruSobolevA. V.fake@neicon.ruSkrekS. V.fake@neicon.ruWolkensteinP.fake@neicon.ruYunovidovaA. A.anastasia.yunovidova@gmail.comNorth-Western State Medical University named after I. I. Mechnikov, Ministry of Health of the Russian FederationResearch Institute of Medical Mycology named after P. N. Kashkin of the North-Western State Medical University
named after I. I. Mechnikov, Ministry of Health of the Russian FederationThe Pierre Wolkenstein French Dermatological ClinicDermatological Service of the Henri Mondor University Hospital2912201793641460202201802022018Copyright © 2017, Rodionov A.N., Sobolev A.V., Skrek S.V., Wolkenstein P., Yunovidova A.A.2017Purulent hydradenitis is a chronic relapsing disease that affects 4% of the population, caused by uncontrolled growth of hair follicle and apocrine gland cells, which leads to the development of autoimmune and then septic inflammation. The provoking factors are obesity, smoking, formation of apocrine glands in the body. The variety of subordinates of Suppurative hydradenitis, differences in the prognosis and course of the disease, as well as the need to manage patients with this pathology in the surgical department, determine the standardization of the therapeutic algorithm and the objectification of the degree of clinical response to the therapy using scoring scales.purulent hydradenitisNotch pathwayTh17 cellssmokingobesityгнойный гидраденитNotch-путьTh17-клеткикурениеожирение[1. Kurzen H., Kurokawa I., Jemec G. B. et al. What Causes Hidradenitis Suppurativa? Exp. Dermatol. 2008;17(5):455–456.][2. Jemec G. B. The Symptomatology of Hidradenitis Suppurativa in Women. Br. J. Dermatol. 1988;119(3):345–350.][3. Melnik B. C., Plewig G. Impaired Notch-MKP-1 Signalling in Hidradenitis Suppurativa: an Approach to Pathogenesis by Evidence from Translational Biology. Exp. Dermatol. 2013;22(3):172–177.][4. Zouboulis C. C., Desai N., Emtestam L. et al. European S1 Guideline for the Treatment of Hidradenitis Suppurativa/Acne Inversa. J. Eur. Acad. Dermatol. Venereol. 2015;29(4):619–644.][5. Canoui-Poitrine F., Le Thuaut A., Revuz J. E. et al. Identification of Three Hidradenitis Suppurativa Phenotypes: Latent Class Analysis of a Cross-Sectional Study. J. Invest. Dermatol. 2013;133(6):1506–1511.][6. Poli F., Wolkenstein P., Revuz J. Back and Face Involvement in Hidradenitis Suppurativa. Dermatology. 2010;221(2):137–141.][7. Canoui-Poitrine F., Revuz J. E., Wolkenstein P. et al. Clinical Characteristics of a Series of 302 French Patients with Hidradenitis Suppurativa, with an Analysis of Factors Associated with Disease Severity. J. Am. Acad. Dermatol. 2009;61(1):51–57.][8. Sartorius K., Lapins J., Emtestam L., Jemec G. B. Suggestions for Uniform Outcome Variables when Reporting Treatment Effects in Hidradenitis Suppurativa. Br. J. Dermatol. 2003;149(1):211–213.][9. Freysz M., Jemec G. B., Lipsker D. A Systematic Review of Terms Used to Describe Hidradenitis Suppurativa. Br. J. Dermatol. 2015;173(5):1298–1300.][10. Kimball A. B., Kerdel F., Adams D. et al. Adalimumab for the Treatment of Moderate to Severe Hidradenitis Suppurativa: a Parallel Randomized Trial. Ann. Intern. Med. 2012;157(12):846–855.][11. Grant A., Gonzalez T., Montgomery M. O. et al. Infliximab Therapy for Patients with Moderate to Severe Hidradenitis Suppurativa: a Randomized,]