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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">3615</article-id><article-id pub-id-type="doi">10.25208/vdv3615</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>GUIDELINES FOR PRACTITIONERS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The possibilities of using injectables in the treatment of atrophic scars</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности применения инъекционных методов в лечении атрофических рубцов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1021-4606</contrib-id><name-alternatives><name xml:lang="en"><surname>Akopyan</surname><given-names>Inessa K.</given-names></name><name xml:lang="ru"><surname>Акопян</surname><given-names>Инесса Хачатуровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Candidate for a Degree</p></bio><bio xml:lang="ru"><p>соискатель</p></bio><email>Ines-akopyan@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4330-2570</contrib-id><contrib-id contrib-id-type="spin">7341-2370</contrib-id><name-alternatives><name xml:lang="en"><surname>Murakov</surname><given-names>Stanislav V.</given-names></name><name xml:lang="ru"><surname>Мураков</surname><given-names>Станислав Вячеславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Associate Professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>dr.Stanislavb@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Academy of Postgraduate education under Federal Scientific and Clinical Center of Federal Medical-Biological Agency</institution></aff><aff><institution xml:lang="ru">Академия постдипломного образования Федерального научно-клинического центра специализированных видов медицинской помощи и медицинских технологий Федерального медико-биологического агентства</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-10-25" publication-format="electronic"><day>25</day><month>10</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-05-20" publication-format="electronic"><day>20</day><month>05</month><year>2024</year></pub-date><volume>100</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>59</fpage><lpage>65</lpage><history><date date-type="received" iso-8601-date="2023-02-06"><day>06</day><month>02</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-09-26"><day>26</day><month>09</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Akopyan I.K., Murakov S.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Акопян И.Х., Мураков С.В.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Akopyan I.K., Murakov S.V.</copyright-holder><copyright-holder xml:lang="ru">Акопян И.Х., Мураков С.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/3615">https://vestnikdv.ru/jour/article/view/3615</self-uri><abstract xml:lang="en"><p>Atrophic scars are a common complication that accompanies the healing of vulgar acne. The condition is quite widespread among young people, and their physical and psychological consequences with improper treatment can persist throughout life. There are many therapies for atrophic scars, but limited efficacy and high frequency of side effects limit use of these methods. For optimal treatment of a patient’s scar, it is necessary to predict which treatment will prtovide the most satisfactory result in the short period of time with the minimum number of side effects. Analysis of numerous studies shows that there is no panacea for the treatment of atrophic scars, which explains the developing trend towards the development of combined treatment methods. The purpose of our review is to analyze injectable methods of therapy for atrophic scars with an emphasis on the latest achievements of the previous decade, since in recent years these methods have shown themselves not only as one of the most successful in therapy, but also, according to most authors, there is a huge potential to increase the efficacy of treatment in severe cases. Although, it is difficult to make an unbiased comparison of each therapy method due to the different sample sizes of studies, the strength of evidence, the specifics of therapy and other factors, nevertheless, there is a possibility of reaching consensus on which treatment methods are optimally suited for certain types of scars. This should be an absolute determining factor for choosing the best therapeutic strategy, whether it is monotherapy or combination therapy, in the treatment of atrophic scars with minimum side effects.</p></abstract><trans-abstract xml:lang="ru"><p>Атрофические рубцы являются распространенным осложнением, которым сопровождается заживление акне. Они достаточно широко распространены среди молодых людей, и их физические и психологические последствия при ненадлежащем лечении могут сохраняться на протяжении всей жизни. Существует множество методов терапии атрофических рубцов, но ограниченная эффективность и высокая частота побочных эффектов сдерживают их применение. Для оптимальной терапии рубцов необходимо с высокой вероятностью прогнозировать, какое лечение даст наиболее удовлетворительный результат за самый короткий период времени с минимальным количеством побочных эффектов у большинства респондентов. Анализ многочисленных исследований показывает, что не существует панацеи для лечения атрофических рубцов, это объясняет развивающуюся тенденцию к разработке комбинированных методов лечения. Целью нашего обзора является анализ инъекционных методов терапии атрофических рубцов с упором на последние достижения предшествующего десятилетия, поскольку за последние годы именно эти методы не только показали себя как одни из самых успешных в терапии, но и обладают, по мнению большинства авторов, огромным потенциалом повышения эффективности лечения тяжелых случаев. Хотя беспристрастное сравнение каждого метода терапии трудно провести из-за различных размеров выборки исследований, силы доказательной базы, особенностей проведения терапии и прочих факторов, тем не менее есть вероятность достижения консенсуса в отношении того, какие методы лечения оптимально подходят для определенных типов рубцов. Это должно являться безусловным определяющим фактором для выбора наилучшей терапевтической стратегии, будь то монотерапия или очетанное применение, при лечении атрофических рубцов с минимальным количеством побочных эффектов и осложнений.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cicatrix</kwd><kwd>injections</kwd><kwd>dermal fillers</kwd><kwd>plasma skin regeneration</kwd><kwd>stem cells</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>рубцы</kwd><kwd>инъекционная терапия</kwd><kwd>филлеры</kwd><kwd>PRP-терапия</kwd><kwd>стволовые клетки</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Oge’ LK, Broussard A, Marshall MD. Acne vulgaris: diagnosis and treatment. Am Fam Physician. 2019;100(8):475–484.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Zhou L, Liu X, Li X, He X, Xiong X, Lai J. 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