Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov40110.25208/0042-4609-2018-94-3-20-29SHORT COMMUNICATIONКРАТКИЕ СООБЩЕНИЯOrigin, function and role in the development of skin diseases CLA+T-lymphocytesРоль CLA+T-клеток в развитии кожных заболеванийPatrushevA. V.ПатрушевА. В.
Russian Federation

Aleksandr V. Patrushev — Cand. Sci. (Medicine), Research Assistant, Department of Skin and Sexually Transmitted Diseases

Academician Lebedev str., 6, Saint Petersburg, 194044

Александр Владимирович Патрушев — кандидат медицинских наук, ассистент кафедры кожных и венерических болезней

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

alexpat2@yandex.ruSamtsovA. V.СамцовА. В.
Russian Federation

Aleksey V. Samtsov — Dr. Sci. (Medicine), Prof., Departmental Head, Department of Skin and Sexually Transmitted Diseases

Academician Lebedev str., 6, Saint Petersburg, 194044

Алексей Викторович Самцов — доктор медицинских наук, профессор, заведующий кафедрой кожных и венерических болезней

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

avsamtsov@mail.ruNikitinV. Yu.НикитинВ. Ю.
Russian Federation

Vladimir Yu. Nikitin — Dr. Sci. (Medicine), Head of the Immunological Laboratory, Centre for Clinical Laboratory Diagnostics

Academician Lebedev str., 6, Saint Petersburg, 194044

Владимир Юрьевич Никитин — доктор медицинских наук, заведующий иммунологической лабораторией центра клинической лабораторной диагностики

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

vladimiryn@mail.ruIvanovA. М.ИвановА. М.
Russian Federation

Andrey M. Ivanov — Dr. Sci. (Medicine), Corresponding Member of the Russian Academy of Sciences, Prof., Head of the Department of Clinical Biochemistry and Laboratory Diagnostics, S. M. Kirov Military Medical Academy of the Ministry of Defence of the Russian Federation

Academician Lebedev str., 6, Saint Petersburg, 194044

Андрей Михайлович Иванов — доктор медицинских наук, член-корреспондент РАН, профессор, заведующий кафедрой клинической биохимии и лабораторной диагностики Военно-медицинской академии им. С. М. Кирова Министерства обороны Российской Федерации

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

iamvma@mail.ruGumilevskayaO. Р.ГумилевскаяO. П.
Russian Federation

Oksana P. Gumilevskaya — Dr. Sci. (Medicine), Ass. Prof., Head of the Centre for Clinical Laboratory Diagnostics

Academician Lebedev str., 6, Saint Petersburg, 194044

Оксана Петровна Гумилевская — доктор медицинских наук, доцент, начальник центра клинической лабораторной диагностики

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

ogum@mail.ruSukharevA. V.СухаревА. В.
Russian Federation

Aleksey V. Sukharev — Dr. Sci. (Medicine), Prof., Department of Skin and Sexually Transmitted Diseases

Academician Lebedev str., 6, Saint Petersburg, 194044

Алексей Владимирович Сухарев — доктор медицинских наук, профессор, профессор кафедры кожных и венерических болезней

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

asoukharev@mail.ruSukhinaI. A.СухинаИ. А.
Russian Federation

Irina A. Sukhina — Cand. Sci. (Biology), Lecturer, Department of Clinical Biochemistry and Laboratory Diagnostics

Academician Lebedev str., 6, Saint Petersburg, 194044

Ирина Александровна Сухина — кандидат биологических наук, преподаватель кафедры клинической биохимии и лабораторной диагностики

194044, г. Санкт-Петербург, ул. Академика Лебедева, д. 6

kinya2000@mail.ruS. M. Kirov Militar y Medical Academy of the Ministr y of Defence of the Russian FederationВоенно-медицинская академия им. С. М. Кирова Министерства обороны Российской Федерации2307201894320292208201822082018Copyright ©; 2018, Patrushev A.V., Samtsov A.V., Nikitin V.Y., Ivanov A.М., Gumilevskaya O.Р., Sukharev A.V., Sukhina I.A.Copyright ©; 2018, Патрушев А.В., Самцов А.В., Никитин В.Ю., Иванов А.М., Гумилевская O.П., Сухарев А.В., Сухина И.А.2018Patrushev A.V., Samtsov A.V., Nikitin V.Y., Ivanov A.М., Gumilevskaya O.Р., Sukharev A.V., Sukhina I.A.Патрушев А.В., Самцов А.В., Никитин В.Ю., Иванов А.М., Гумилевская O.П., Сухарев А.В., Сухина И.А.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/401

The idea of CLA+T-lymphocytes, which are a special subpopulation of cells with a tropic to the skin, is given. The issues of maturation, migration and functional features of CLA+T-cells are considered. Special attention is paid to the different phenotype of memory T-cells. Modern data concerning the role of CLA+T-cells in the pathogenesis of autoimmune and allergic dermatoses, as well as malignant skin tumors are also presented. The conclusion about the necessity of further study of CLA +T-lymphocytes for detailed understanding of pathogenesis and search of variants of targeted therapy in psoriasis, atopic dermatitis, skin lymphomas and other skin diseases is made.

Дано представление о CLA+Т-лимфоцитах, являющихся особой субпопуляцией клеток с тропностью к коже. Рассмотрены вопросы созревания, миграции и функциональных особенностей CLA+Т-клеток. Особое внимание уделено различным фенотипам Т-клеток памяти. Обобщены современные данные, касающиеся роли CLA+Т-клеток в патогенезе аутоиммунных и аллергических дерматозов, а также злокачественных опухолей кожи. Сделан вывод о необходимости дальнейшего изучения CLA+Т-лимфоцитов для детального понимания механизмов развития и поиска вариантов таргетной терапии при псориазе, атопическом дерматите, лимфомах кожи и других кожных заболеваниях.

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