Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov45510.25208/0042-4609-2018-94-6-42-51CLINICAL CASE REPORTSНАБЛЮДЕНИЕ ИЗ ПРАКТИКИLinear IgA bullous dermatosisЛинеарный IgA-зависимый буллезный дерматозZnamenskayaL. F.ЗнаменскаяЛ. Ф.
Russian Federation

Dr. Sci. (Med.), Leading Researcher, Department of Dermatology,

Korolenko str., 3, bldg 6, Moscow, 107076

д.м.н., ведущий научный сотрудник отдела дерматологии,

107076, г. Москва, ул. Короленко, д. 3, стр. 6

ChikinV. V.ЧикинВ. В.
Russian Federation

Dr. Sci. (Med.), Senior Researcher, Department of Dermatology,

Korolenko str., 3, bldg 6, Moscow, 107076

д.м.н., старший научный сотрудник отдела дерматологии,

107076, г. Москва, ул. Короленко, д. 3, стр. 6

platonova1105@gmail.comNefedovaM. A.НефедоваМ. А.
Russian Federation

Junior Researcher, Department of Dermatology,

Korolenko str., 3, bldg 6, Moscow, 107076

младший научный сотрудник отдела дерматологии,

107076, г. Москва, ул. Короленко, д. 3, стр. 6

State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationГосударственный научный центр дерматовенерологии и косметологии Министерства здравоохранения Российской Федерации1712201894642511704201917042019Copyright ©; 2018, Znamenskaya L.F., Chikin V.V., Nefedova M.A.Copyright ©; 2018, Знаменская Л.Ф., Чикин В.В., Нефедова М.А.2018Znamenskaya L.F., Chikin V.V., Nefedova M.A.Знаменская Л.Ф., Чикин В.В., Нефедова М.А.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/455

Aim: to present a clinical case of linear IgA bullous dermatosis.

Materials and methods. A 44 years old patient complaining of skin rashes on the trunk and extremities, accompanied by severe itching was examined. We carried out a morphological investigation of biopsy samples derived from the lesion and apparently unaffected skin areas using the method of indirect immunofluorescence.

Results. The patient having rashes in the form of multiple vesicles and small bubbles with a tight cover, which had been grouped into figures resembling pearl necklaces, demonstrated the presence of focal subepidermal cracks (subepidermal bubble in one location), as well as a linear deposition of IgA along the epidermal basement membrane. According to the clinical picture and following the histological and immunofluorescent investigation of skin biopsies, the patient was diagnosed with linear IgA bullous dermatosis. Lesion regression was achieved as a result of systemic therapy with prednisolone at a dose of 50 mg per day.

Conclusion. The diagnosis of linear IgA bullous dermatosis should be made on the basis of skin biopsy investigation by the method of indirect immunofluorescence. Systemic glucocorticosteroids are seen as an effective approach to the treatment of such patients.

Цель: представить клинический случай линеарного IgA-зависимого буллезного дерматоза.

Материал и методы. Пациентке в возрасте 44 лет, обратившейся с жалобами на высыпания на коже туловища и конечностей, сопровождавшиеся выраженным зудом, были проведены морфологическое исследование биоптата кожи из очага поражения и исследование биоптата видимо непораженной кожи методом непрямой иммунофлюоресценции.

Результаты. У пациентки с высыпаниями в виде множественных пузырьков и мелких пузырей с плотной покрышкой, которые группировались в фигуры, напоминающие жемчужные ожерелья, обнаружено очаговое формирование субэпидермальных щелей, на одном из участков — субэпидермальный пузырь, а также линейное отложение IgA вдоль базальной мембраны эпидермиса. На основании данных клинической картины, гистологического и иммунофлюоресцентного исследований биоптатов кожи был установлен диагноз линеарного IgA-зависимого дерматоза. Регресс высыпаний достигнут в результате системной терапии преднизолоном в дозе 50 мг в сутки.

Заключение. Для диагностики линеарного IgA-зависимого буллезного дерматоза необходимо проведение исследования биоптата кожи методом непрямой иммунофлюоресценции. Эффективным средством терапии больных этим заболеванием являются системные глюкокортикостероиды.

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