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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">467</article-id><article-id pub-id-type="doi">10.25208/0042-4609-2019-95-1-52-58</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DRUG TREATMENT IN DERMATOVENEROLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The modern approach of advanced botulinum toxin therapy: application of various dilutions, techniques and levels of administration</article-title><trans-title-group xml:lang="ru"><trans-title>Современный подход «продвинутой ботулинотерапии»: применение различных разведений, техник и уровней введения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aksenenko</surname><given-names>I. P.</given-names></name><name xml:lang="ru"><surname>Аксененко</surname><given-names>И. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.), Dermatovenerologist, Cosmetologist, Director</p></bio><bio xml:lang="ru"><p>к.м.н., врач-дерматовенеролог, косметолог, директор</p></bio><email>i.aksenenko@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dr. Aksenenko’s Clinic of Aesthetic Medicine, LLC</institution></aff><aff><institution xml:lang="ru">ООО «Клиника эстетической медицины Dr. Aksenenko»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-03-02" publication-format="electronic"><day>02</day><month>03</month><year>2019</year></pub-date><volume>95</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>52</fpage><lpage>58</lpage><history><date date-type="received" iso-8601-date="2019-05-30"><day>30</day><month>05</month><year>2019</year></date><date date-type="accepted" iso-8601-date="2019-05-30"><day>30</day><month>05</month><year>2019</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Aksenenko I.P.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Аксененко И.П.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Aksenenko I.P.</copyright-holder><copyright-holder xml:lang="ru">Аксененко И.П.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/467">https://vestnikdv.ru/jour/article/view/467</self-uri><abstract xml:lang="en"><p>One modern direction of botulinum toxin therapy in aesthetic medicine is its individualization by taking into account patients’ specific characteristics. On the example of using incobotulinumtoxin A (botulinum toxin type A, BTA), this paper considers the possibility of using the entire range of its concentrations in creating a differentiated approach to correcting mimic wrinkles in different zones and muscular levels. This is expected to achieve the required level of individualization for an optimal aesthetic result. Aim. To assess and justify the efficacy of BTA (on the example of incobotulinumtoxin A) in various concentrations for correcting mimic wrinkles in different zones and muscular levels.</p></abstract><trans-abstract xml:lang="ru"><p>Одной из основных тенденцией современной ботулинотерапии в эстетической медицине является персонификация методики с учетом индивидуальных особенностей пациента. На примере применения инкоботулотоксина А (ботулинического токсина типа А, БТА) в коррекции мимических морщин мы попытались рассмотреть возможности использования всего спектра концентраций, дифференцированного подхода в различных зонах и мышечных уровнях, что обеспечивает индивидуализацию методики и гармоничный эстетический результат. Целью данной работы явилась оценка и обоснование возможности и эффективности применения БТА (на примере инкоботулотоксина А) с использованием всего спектра концентраций в коррекции мимических морщин на разных зонах и мышечных уровнях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>mimic wrinkle correction</kwd><kwd>incobotulinumtoxin A</kwd><kwd>BTA restoration options</kwd><kwd>botulinum toxin therapy individualization</kwd><kwd>application of various BTA dilutions</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>коррекция мимических морщин</kwd><kwd>инкоботулотоксин А</kwd><kwd>варианты восстановления БТА</kwd><kwd>персонификация методики ботулинотерапии</kwd><kwd>применение различных разведений БТА</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Muti G. F., Basso M. Treatment of Lateral Periorbital Lines with Different Dilutions of Incobotulinumtoxin A. 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