Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov47910.25208/0042-4609-2019-95-2-8-14REVIEWSОБЗОР ЛИТЕРАТУРЫClinical and pathological changes in the skin with granuloma annulareКлинико-патоморфологические изменения кожи при кольцевидной гранулемеKharchilavaM. G.ХарчилаваМ. Г.
Russian Federation

Maya G. Kharchilava — Research Assistant, Department of Skin and Venereal Diseases, tel.: +7 (981) 882-55-55

Майя Гиоргиевна Харчилава — ассистент кафедры кожных и венерических болезней; тел. +7 (981) 882-55-55

KhairutdinovV. R.ХайрутдиновВ. Р.
Russian Federation

Vladislav R. Khairutdinov — Assoc. Prof., Department of Skin and Venereal Diseases

Владислав Ринатович Хайрутдинов* — доцент кафедры кожных и венерических болезней

haric03@list.ruBelousovaI. E.БелоусоваИ. Э.
Russian Federation

Irena E. Belousova — Dr. Sci. (Med.), Prof., Department of Skin and Venereal Diseases

Ирена Эдуардовна Белоусова — д.м.н., профессор кафедры кожных и венерических болезней

SamtsovA. V.СамцовА. В.
Russian Federation

Alexey V. Samtsov — Head of the Department of Skin and Venereal Diseases

Алексей Викторович Самцов — заведующий кафедрой кожных и венерических болезней

S. M. Kirov Military Medical Academy, Ministry of Defence of the Russian FederationВоенно-медицинская академия им. С. М. Кирова Министерства обороны Российской Федерации170420199528141707201917072019Copyright ©; 2019, Kharchilava M.G., Khairutdinov V.R., Belousova I.E., Samtsov A.V.Copyright ©; 2019, Харчилава М.Г., Хайрутдинов В.Р., Белоусова И.Э., Самцов А.В.2019Kharchilava M.G., Khairutdinov V.R., Belousova I.E., Samtsov A.V.Харчилава М.Г., Хайрутдинов В.Р., Белоусова И.Э., Самцов А.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/479

Granuloma annulare (GA) is a dermatosis of unknown etiology, which has distinctive clinical and histological features. In this article, we present current information about the etiology, pathogenesis, clinical picture and pathomorphological signs of GA, as well as conduct differential diagnosis of GA with diseases that have a similar clinical and histological picture.

Кольцевидная гранулема (КГ) представляет собой дерматоз неясной этиологии, который имеет отличительные клинические и гистологические особенности. В данной статье мы представляем современные сведения об этиологии, патогенезе, клинической картине и патоморфологических признаках КГ, а также проводим дифференциальную диагностику КГ с заболеваниями, имеющими схожую клиническую и гистологическую картину.

granuloma annulareetiologypathogenesispathomorphological signsкольцевидная гранулемаэтиологияпатогенезпатоморфологические признаки1. Studer E. M., Calza A. M., Saurat J. H. Precipitating factors and associated diseases in 84 patients with granuloma annulare: a retrospective study. Dermatology. 1996;193:364–368.2. Lukacs J., Schliemann S., Elsner P. Treatment of generalized granuloma annulare — a systematic review. J Eur Acad Dermatol Venerol. 2015 Aug;29(8):1467–1480.3. Piette E. W., Rosenbach M. Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. J Am Acad Dermatol. 2016 Sep;75(3):457–465.4. Haim S., Friedman-Birnbaum R., Shafrir A. Generalized granuloma annulare: relationship to diabetes mellitus as revealed in 8 cases. Br J Dermatol. 1970;83:302–305.5. Muhlemann M. F., Williams D. R. Localized granuloma annulare is associated with insulin-dependent diabetes mellitus. Br J Dermatol. 1984;111:325–329.6. Meier-Ewert H., Allenby C. F. Grannulomaannulare and diabetes mellitus. Arch Dermatol Forsch.1971;241:194–198.7. Li A., Hogan D. J., Sanusi I. D., Smoller B. R. Granuloma annulare and malignant neoplasms. Am J Dermatopathol. 2003;25:113–116.8. Cohen P. R. Granuloma annulare, relapsing polychondritis, sarcoidosis, and systemic lupus erythematosus: conditions whose dermatologic manifestations may occur as hematologic malignancy-associated mucocutaneous paraneoplastic syndromes. Int J Dermatol. 2006;45:70–80.9. Shimizu S., Yasui C., Tsuchiya K. Atypical generalized granuloma annulare associated with two visceral cancers. J Am Acad Dermatol. 2006;54(5 Suppl):S236–S238.10. Setoyama M., Kerdel F. A., Byrnes J. J., Kanzaki T. Granuloma annulare associated with Hodgkin’s disease. Int J Dermatol. 1997;36:445–448.11. Schwartz R. A., Hansen R. C., Lynch P. J. Hodgkin’s disease and granuloma annulare. Arch Dermatol. 1981;117:185–186.12. Vazquez-Lopez F., Gonzalez-Lopez M. A., Raya-Aguado C., PerezOliva N. Localized granuloma annulare and autoimmune thyroiditis: a new case report. J Am Acad Dermatol. 2000;43(5 Pt 2):943–945.13. Watanabe S., Tanaka M., Kobayashi K. et al. Remission of generalized erythematous granuloma annulare after improvement of hyperlipidemia and review of the Japanese literature. Dermatol Pract Concept. 2014;4:97–100.14. Chang S. E., Bae G. Y., Moon K. C., Do S. H., Lim Y. J. Subcutaneous granuloma annulare following herpes zoster. Int J Dermatol. 2004;43:298–299.15. Ruocco E., Baroni A., Cutri F. T., Filioli F. G. Granuloma annulare in a site of healed herpes zoster: Wolf’s isotopic response. J Eur Acad Dermatol Venereol. 2003;17:686–688.16. Ma H. J., Zhu W. Y., Yue X. Z. Generalized granuloma annulare associated with chronic hepatitis B virus infection. J Eur Acad Dermatol Venereol. 2006;20:186–189.17. Granel B., Serratrice J., Rey J. et al. Chronic hepatitis C virus infection associated with a generalized granuloma annulare. J Am Acad Dermatol. 2000;43(5 Pt 2):918–919.18. Gradwell E., Evans S. Perforating granuloma annulare complicating tattoos. Br J Dermatol. 1998;138:360–361.19. Takayama K., Satoh T., Yokozeki H. Papular granuloma annulare with subcutaneous granulomatous reaction induced by a bee sting. Acta Derm Venereol. 2008;88:519–520.20. Kakurai M., Kiyosawa T., Ohtsuki M., Nakagawa H. Multiple lesions of granuloma annulare following BCG vaccination: case report and review of the literature. Int J Dermatol. 2001;40:579–581.21. Strahan J. E., Cohen J. L., Chorny J. A. Granuloma annulare as a complication of mesotherapy: a case report. Dermatol Surg. 2008 Jun;34(6):836–838. DOI: 10.1111/j.1524-4725.2008.34156.x. Epub 2008 Mar 31.22. Krahl D., Hartschuh W., Tilgen W. Granuloma annulareperforans in herpes zoster scars. J Am Acad Dermatol. 1993;29(5 Pt 2):859–862.23. Guill M. A., Goette D. K. Granuloma annulare at sites of healing herpes zoster. Arch Dermatol. 1978;114:1383.24. Singh S. K., Manchanda K., Bhayana A. A., Verma A. Allopurinol induced granuloma annulare in a patient of lepromatous leprosy. J Pharmacol Pharmacother. 2013;4:152–154.25. Cassone G., Tumiati B. Granuloma annulare as a possible new adverse effect of topiramate. Int J Dermatol. 2014;53:259–261.26. Ahmad U., Li X., Sodeman T., Daboul I. Hepatitis C virus treatment with pegylated interferon-alfa therapy leading to generalized interstitial granuloma annulare and review of the literature. Am J Ther. 2013;20:585–587.26. Dahl M. V., Ullman S., Goltz R. W. Vasculitis in granuloma annulare: histopathology and direct immunofluorescence. Arch Dermatol. 1977;113:463–467.27. Smith M. D., Downie J. B., DiCostanzo D. Granuloma annulare. International Journal of Dermatology. 1997;36(5):326–333.28. Buechner S. A., Winkelmann R. K., Banks P. M. Identification of T-cell subpopulations in granuloma annulare. Arch Dermatol. 1983 Feb;119(2):125–128.29. Umbert P., Belcher R. W., Winkelmann R. K. Lymphokines (MIF) in the serum of patients with sarcoidosis and cutaneous granuloma annulare. Br J Dermatol. 1976;95:481–485.30. Piette E. W. Rosenbach M. Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol. 2016 Sep;75(3):467–479.31. Friedman S. J., Winkelmann R. K. Familial granuloma annulare. Report of two cases and review of the literature. J Am Acad Dermatol. 1987 Mar;16(3 Pt 1):600–605.32. Knoell K. A. Efficacy of adalimumab in the treatment of generalized granuloma annulare in monozygotic twins carrying the 8.1 ancestral haplotype. Arch Dermatol. 2009 May;145(5):610–611. DOI: 10.1001/archdermatol.2009.9233. Asai J. What is new in the histogenesis of granulomatous skin diseases? J Dermatol. 2017 Mar;44(3):297–303.34. Dabski K., Winkelmann R. K. Generalized granuloma annulare: Clinical laboratory findings in 100 patients. J Am Acad Dermatol. 1989;20:39–47.35. Zhong W., Shao Y., Ye T., Li J., Yu B., Dou X. Perforating granuloma annulare: a case report and literature review. J Eur Acad Dermatol Venereol. 2016 Jul;30(7):1246–1247. DOI: 10.1111/jdv.1317436. Alves J., Barreiros H., Bártolo E. Perforating Granuloma Annulare — An Unusual Subtype of a Common Disease. Healthcare (Basel). 2014 Sep 4;2(3):338–345.37. Boudhir H., Bouhllab J., Rimani M., Senouci K., Hassam B. Generalized annular granuloma. Presse Med. 2014 Nov;43(11):1299–1301.38. Keimig E. L. Granuloma Annulare. Dermatol Clin. 2015 Jul;33(3):315–329.39. Rosenbach M., English J.C. Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification. Dermatol Clin. 2015 Jul;33(3):373–387.40. Kallioinen M., Sandberg M., Kinnunen T., Oikarinen A. Collagen synthesis in granuloma annulare. J Invest Dermatol. 1992 Apr;98(4):463–468.41. Umbert P., Winkelmann R. K. Histologic, ultrastructural and histochemical studies of granuloma annulare. Arch Dermatol. 1977 Dec;113(12):1681–1686.42. Dabski K., Winkelmann R.K. Generalized granuloma annulare: histopathology and immunopathology. Systematic review of 100 cases and comparison with localized granuloma annulare. J Am Acad Dermatol. 1989 Jan;20(1):28–39.43. Huizenga T., Kado J. A., Pellicane B., Borovicka J., Mehregan D. R., Mehregan D.A. Interstitial granulomatous dermatitis and palisaded neutrophilic granulomatous dermatitis. Cutis. 2018 May;101(5):E19–E21.44. Tebeica T., Voicu C., Patterson J. W., Mangarov H., Lotti T., Wollina U. et al. Interstitial Granulomatous Dermatitis. Open Access Maced J Med Sci. 2017 Jul 21;5(4):543–544.45. Terziroli Beretta-Piccoli B., Mainetti C., Peeters M. A., Laffitte E. Cutaneous Granulomatosis: a Comprehensive Review. Clin Rev Allergy Immunol. 2018 Feb;54(1):131–146.46. Wick M. R. Granulomatous &histiocytic dermatitides. Semin Diagn Pathol. 2017 May;34(3):301–311.47. Kalen J. E., Shokeen D., Ramos-Caro F., Motaparthi K. Palisaded neutrophilic granulomatous dermatitis: Spectrum of histologic findings in a single patient. JAAD Case Rep. 2017 Sep 8;3(5):425–428.48. Ragaz A., Ackerman A. B. Is actinic granuloma a specific condition? Am J Dermatopathol. 1979;1:43–50.49. Barnhill R. L., Goldenhersh M. A. Elastophagocytosis: a non-specific reaction pattern associated with inflammatory processes in sun-protected skin. J Cutan Pathol. 1989;16:199–202.50. Барбинов В. В., Чирский В. С., Тарасенко Г. Н., Барбинов Д. В. Результаты изучения патоморфоза красного плоского лишая на основе определения его современных гистологических признаков. Российский журнал кожных и венерических болезней. 2014;(3):42–48. [Barbinov V. V., Chirsky V. S., Tarasenko G. N., Barbinov D. V. Results of the study of pathomorphosis of lichen planus based on the definition of its modern histological features. Russian Journal of Skin and Venereal Diseases. 2014;(3):42–48. (In Russ.)]