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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">48</article-id><article-id pub-id-type="doi">10.25208/0042-4609-2014-90-4-28-34</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>SHORT COMMUNICATION</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Seborrheic keratosis: current concepts of pathogenesis</article-title><trans-title-group xml:lang="ru"><trans-title>Себорейный кератоз: современные представления о патогенезе</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aleksandrova</surname><given-names>A. K.</given-names></name><name xml:lang="ru"><surname>Александрова</surname><given-names>А. К.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>veter278@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smolyannikova</surname><given-names>V. A.</given-names></name><name xml:lang="ru"><surname>Смольянникова</surname><given-names>В. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>veter278@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-08-24" publication-format="electronic"><day>24</day><month>08</month><year>2014</year></pub-date><volume>90</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>28</fpage><lpage>34</lpage><history><date date-type="received" iso-8601-date="2017-08-24"><day>24</day><month>08</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Aleksandrova A.K., Smolyannikova V.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, Александрова А.К., Смольянникова В.А.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Aleksandrova A.K., Smolyannikova V.A.</copyright-holder><copyright-holder xml:lang="ru">Александрова А.К., Смольянникова В.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/48">https://vestnikdv.ru/jour/article/view/48</self-uri><abstract xml:lang="en"><p>The article covers problems of seborrheic keratosis. The authors discuss current concepts of the etiology and pathogenesis of the disease paying special attention to the histology and immunohistochemistry of different forms and diverse clinical presentations. They describe Leser - Trelat syndrome as well as potential neoplastic transformation of seborrheic keratomas and their association with malignant skin neoplasms.</p></abstract><trans-abstract xml:lang="ru"><p>Рассматриваются вопросы себорейного кератоза. Обсуждаются современные взгляды на этиологию и патогенез заболевания, особое внимание уделено гистологическим и иммунногистохимическим особенностям разных форм, разнообразию клинических проявлений. Описан синдром Лезера - Трела, показана возможность малигнизации себорейных кератом, их ассоциация со злокачественными новообразованиями кожи.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>себорейный кератоз</kwd><kwd>иммунногистохимия</kwd><kwd>эндотелин-1</kwd><kwd>онкогены р16</kwd><kwd>р53</kwd><kwd>р63</kwd><kwd>инсулин</kwd><kwd>синдром Лезера - Трела</kwd><kwd>seborrheic keratosis</kwd><kwd>immunohistochemistry</kwd><kwd>endothelin-1</kwd><kwd>р16</kwd><kwd>р53</kwd><kwd>р63 oncogenes</kwd><kwd>insulin</kwd><kwd>Leser - Trelat syndrome</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Skripkin U.K., Mordovzeva V.N. Skin and venereal diseases. The management for doctors. M: Medicina; 1999. [Скрипкин Ю.К., Мордовце-ва В.Н. Кожные и венерические болезни. Руководство для врачей. М: Медицина; 1999.]</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Mordovzeva V.N., Zvetkova G.N., Skin pathology. 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