Vestnik dermatologii i venerologiiVestnik dermatologii i venerologii0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov50510.25208/0042-4609-2019-95-4-57-66Langerhans cell histiocytosis in an adult patientKaramovaA. E.<p>Cand. Sci. (Med.), Head of the Dermatology Department,</p><p>Korolenko str., 3, bldg 6, Moscow, 107076</p>fake@neicon.ruChikinV. V.<p>Dr. Sci. (Med.), Senior Researcher, Dermatology Department,</p><p>Korolenko str., 3, bldg 6, Moscow, 107076</p>chikin@cnikvi.ruZnamenskayaL. F.<p>Dr. Sci. (Med.), Leading Researcher, Dermatology Department,</p><p>Korolenko str., 3, bldg 6, Moscow, 107076</p>fake@neicon.ruNefedovaM. A.<p>Junior Researcher, Dermatology Department,</p><p>Korolenko str., 3, bldg 6, Moscow, 107076</p>fake@neicon.ruMikhinaV. A.<p>Dermatovenerologist, Department of Clinical Dermatology,</p><p>Korolenko str., 3, bldg 6, Moscow, 107076</p>fake@neicon.ruBattalovaN. S.<p>Resident Physician,</p><p>Korolenko str., 3, bldg 6, Moscow, 107076</p>fake@neicon.ruState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian Federation1908201995457661910201919102019Copyright © 2019, Karamova A.E., Chikin V.V., Znamenskaya L.F., Nefedova M.A., Mikhina V.A., Battalova N.S.2019<p><strong>Aim:</strong> to present a clinical case of a rare dermatosis — Langerhans cell histiocytosis (LCH) in an adult patient.</p><p><strong>Materials and methods</strong>. A clinical and laboratory examination of a 64-year-old woman who had complained of rashes on the skin of the scalp, neck, trunk and lower extremities accompanied by itching was carried out. A histological study of skin biopsy samples from the lesion area, as well as an immunohistochemical study of Langerhans cell markers — langerin and S-100 protein — were performed.</p><p><strong>Results</strong>. Clinical manifestations of the disease, the presence of histiocytic infiltrate in the epidermis and dermis during the histological study and immunohistochemical detection of langerin infiltrate cells and S-100 protein were all consistent with the diagnosis of LCH. The therapy with methotrexate subcutaneously significantly improved the patient’s condition.</p><p><strong>Conclusion</strong>. Verification of the LCH diagnosis requires a histological study of skin biopsy samples and an immunohistochemical study of Langerhans cell markers. The efficacy of methotrexate in the treatment of this disease has been confirmed.</p>Langerhans cell histiocytosishistiocytesmethotrexateгистиоцитоз из клеток Лангергансагистиоцитыметотрексат[1. Badalian-Very G., Vergilio J. A., Degar B. A. et al. Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood. 2010;116:1919–1923.][2. Badalian-Very G., Vergilio J. A., Fleming M., Rollins B. J. Pathogenesis of Langerhans Cell Histiocytosis. 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