Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov5310.25208/0042-4609-2014-90-4-58-67CLINICAL CASE REPORTSНАБЛЮДЕНИЕ ИЗ ПРАКТИКИClinical and morphological features of elastolytic granulomasКлинико-морфологические особенности эластолитических гранулемPatrushevA. V.ПатрушевА. В.
Russian Federation
alexpat2@yandex.ruKhairutdinovV. R.ХайрутдиновВ. Р.
Russian Federation
BelousovaI. E.БелоусоваИ. Э.
Russian Federation
SamtsovA. V.СамцовА. В.
Russian Federation
Military Medical Academy named after S.M. Kirov Ministry of Defense of the Russian FederationФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ24082014904586724082017Copyright ©; 2014, Patrushev A.V., Khairutdinov V.R., Belousova I.E., Samtsov A.V.Copyright ©; 2014, Патрушев А.В., Хайрутдинов В.Р., Белоусова И.Э., Самцов А.В.2014Patrushev A.V., Khairutdinov V.R., Belousova I.E., Samtsov A.V.Патрушев А.В., Хайрутдинов В.Р., Белоусова И.Э., Самцов А.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/53

The authors discuss current data on the classification, etiology and pathogenesis, clinical picture, pathologic features and treatment options of elastolytic granulomas (EGs). The authors disclose main aspects of elastolysis and elastophagocytosis development. Three cases of diseases from the EG group - actinic granuloma and annular elastolytic giant cell granuloma -are described for the first time in the Russian literature.

Представлены современные данные, касающиеся классификации, этиологии и патогенеза, клинической картины, патоморфологических особенностей и вариантов лечения эластолитических гранулем (ЭГ). Рассмотрены основные причины развития эластолиза и эластофагоцитоза. Впервые в отечественной дерматовенерологии описаны три случая заболевания из группы ЭГ: актиническая гранулема и кольцевидная эластолитическая гигантоклеточная гранулема.

эластолитические гранулемыэластофагоцитозактиническая гранулемакольцевидная эластолитическая гигантоклеточная гранулемаelastolytic granulomaselastophagocytosisactinic granulomaannular elastolytic giant cell granulomaDavid Weedon. Weedon’s Skin Pathology. 3rd edition. Churchill Livingstone; 2009.Harmon C.B., Su W.P., Gagne E.J. et al. Ultra-structural evaluation of mid-dermal elastolysis. J Cutan Pathol 1994; 21: 233-8.Fimiani M., Mazzatenta C., Alessandrini C. et al. Mid-dermal elastolysis: an ultrastructural and biochemical study. Arch Dermatol Res 1995; 287: 152-7.Hashimoto K., Tye M.J. Upper dermal elastolysis: a comparative study with mid-dermal elastolysis. J Cutan Pathol 1994; 21: 533-40.Дерматология Фицпатрика в клинической практике: в 3 т. Пер. с англ. ; общ. ред. акад. А.А. Кубановой. М.: Издательство Панфилова; БИНОМ. Лаборатория знаний; 2012.Fasio M. J., Mattei M. G., Passage E. et al. Human elastin gene: new evidence for localization of elastin to the long arm of chromosome 7. Am J Hum Genet 1991; 48: 696-703.Reed W.B., Horowitz R.E., Beighton P. Acquired cutis laxa: primary generalized elastolysis. Arch Dermatol 1971; 103: 661-9.Gambichler T., Linhart C., Wolter M. Middermal elastolysis associated with Hashimoto’s thyroiditis. J Eur Acad Dermatol Venereol 1999; 12: 245-9.Kirsner R.S., Falanga V. Features of an autoimmune process in mid-dermal elastolysis. J Am Acad Dermatol 1992; 27: 832-4.Werb Z., Banda M.J., McKerrow J.H. et al. Elastases and elastin degradation. J Invest Dermatol 1982; 79: 154-9.Loo W.J., Rytina E., Banfield C. Elastophagocytosis: a feature of resolving Sweet’s syndrome. J Eur Acad Dermatol Venereol 2004; 18: 471-3.Taddese S., Weiss A.S., Neubert R.H. et al. Mapping of macrophage elastase cleavage sites in insoluble human skin elastin. Matrix Biol 2008; 27: 420-8.Vaalamo M., Kariniemi A.L., Shapiro S.D. et al. Enhanced expression of human metalloelastase (MMP-12) in cutaneous granulomas and macrophage migration. J Invest Dermatol 1999; 112: 499-505. ЛитератураPatroi I., Annessi G., Girolomoni G. Mid-dermal elastolysis: a clinical, histologic, and immuno-histochemical study of 11 patients. J Am Acad Dermatol 2003; 48: 846-51.Suwabe H., Serizawa A., Kajiwara H. et al. Degenerative processes of elastic fibers in sun-protected and sun-exposed skin: immunoelectron microscopic observation of elastin, fibrillin-1, amyloid P component, lysozyme and alpha1-antitrypsin. Pathol Int 1999; 49: 391-402.Senior R.M., Griffin G.L., Mecham R.P. et al. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J Cell Biol 1984; 99: 870-4.Hauck M., Seres I., Kiss I. et al. Effects of synthesized elastin peptides on human leukocytes. Biochem Mol Biol Int 1995; 37: 45-55.Bernstein E.F., Underhill C.B., Hahn P.J. et al. Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans. Br J Dermatol 1996; 135: 255-62.Cavarra E., Fimiani M., Lungarella G. et al. UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. Biol Chem 2002; 383: 199-206.Brennan M., Bhatti H., Nerusu K. C. et al. Matrix metalloproteinase-1 is the major collagenolytic enzyme responsible for collagen damage in UV-irradiated human skin. Photochem Photobiol 2003; 78: 43-8.Abbas O., Chatrath V., Goldberg L. J. Elastophagocytosis in extragenital lichen sclerosus. J Cutan Pathol 2010; 37: 1032-7.Ragaz A., Ackerman A. B. Is actinic granuloma a specific condition? Am J Dermatopathol 1979; 1: 43-50.Patroi I., Annessi G., Girolomoni G. Mid-dermal elastolysis: a clinical, histologic, and immunohistochemical study of 11 patients. J Am Acad Dermatol 2003; 48: 846-51.Gunes P., Goktay F., Mansur A.T. et al. Collagen-elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases. J Cutan Pathol 2009; 36: 838-44.Barnhill R.L., Goldenhersh M.A. Elastophago-cytosis: a non-specific reaction pattern associated with inflammatory processes in sun-protected skin. J Cutan Pathol 1989; 16: 199-202.Burket J.M., Zelickson A.S. Intracellular elastin in generalized granuloma annulare. J Am Acad Dermatol 1986; 14: 975-81.Friedman-Birnbaum R., Weltfriend S., Kerner H. Elastic tissue changes in generalized granuloma annulare. Am J Dermatopathol 1989; 11: 429-33.Sweeney E.C., McDermott M. Tumor-related cutaneous elastophagocytosis. J Clin Pathol 1996; 49: 81-3.Gunes P., Goktay F., Mansur A.T. et al. Collagen-elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases. J Cutan Pathol 2009; 36: 838-44.El-Khoury J., Kurban M., Abbas O. Elasto-phagocytosis: Underlying mechanisms and associated cutaneous entities. J Am Acad Dermatol 2014; 18: 1-10.O’Brien J.P. Actinic granuloma: an annular connective tissue disorder affecting sun-and heat-damaged (elastotic) skin. Arch Dermatol 1975; 111: 460-6.O’Brien J.P. Is actinic granuloma a specific condition? Am J Dermatopathol 1979; 1 (1): 51-3.Steffen Ch. The Man Behind the Eponym. John P.O. Brien - Actinic Granuloma (O’Brien). Am J Dermatopathol 2002; 24 (3): 264-66.Delgado-Jimenez Y., Perez-Gala S., Penas P. F. et al. O’Brien actinic granuloma presenting as alopecia. J Eur Acad Dermatol Venereol 2006; 20: 226.Wilson E.J. Actinic Granuloma. Am J Dermatopathol 1980; 2 (1): 89-90.Al-Hoqail I. A., Al-Ghambi A., Martinka M. et al. Actinic granuloma and granuloma annulare: are they the same condition? Paper presented at the 38th annual meeting of the American Society of Dermatopathology. J Cutan Pathol 2001; 28: 556.Hanke C.W., Bailin P.L., Roenigk H.H. Annular elastolytic giant cell granuloma (a clinicopathologic study of five cases and a review of similar entities). J Am Acad Dermatol 1979; 1: 413-21.Pock L., Blazkova J., Caloudova H. et al. Annular elastolytic giant cell granuloma causes an irreversible disappearance of the elastic fibres. J Eur Acad Dermatol Venereol 2004; 18 (3): 365-68.Yanagihara M., Kato F. Mori S. Extra- and intracellular digestion of elastic fibers by macrophages in annular elastolytic giant cell granuloma. J Cutan Pathol 1987; 14 (5): 303-8.Hideyuki K., Yumiko U., Hideo Y. et al. Papular lesions associated with annular elastolytic giant cell granuloma. patients. J Am Acad Dermatol 1989; 21: 398-400.Doulaveri G., Tsagroni E., Giannadaki M. et al. Annular elastolytic giant cell granuloma in a 70-year-old woman. Int J Dermatol 2003; 42 (4): 290-291.Vehring K.H., Bonsmann G., Brocker E.B. et al. Das anulare elastolytische Riesenzellgranulomeine - eine Differentialdiagnose kutaner Granulomatosen. Hautarzt 1991; 42: 391-5.Boussault P., Tucker M.L., Weschler J. et al. Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma associated with an annular elastolytic giant cell granuloma. Br J Dermatol 2009; 160 (5): 1126-8.Asahina A., Shirai A., Horita A. et al. Annular elastolytic giant cell granuloma associated with prostate carcinoma: demonstration of human metalloelastase-12 expression. Clin Exp Dermatol 2012; 37: 7072.Lo Schiavo A., Romano F., Alfano R. Unilateral Annular Elastolytic Giant Cell Granuloma in a Hemiplegic Stroke Patient. Am J Dermatopathol 2014; Electronic links: http://journals. lww. com/ amjdermatopathology/ Citation/ publishahead/Unilateral_Annular_Elastolyt-ic_Giant_Cell. 99212. aspx (date of treatment 17.04.2014).Aso Y., Izaki S., Teraki Y. Annular elastolytic giant cell granuloma associated with diabetes mellitus: a case report and review of the Japanese literature. Clin Exp Dermatol 2011; 36: 917-9.De Oliveira F.L., De Barros Silveira L.K.C., De Miranda Machado A. et al. Hybrid Clinical and Histopathological Pattern in Annular Lesions: An Overlap between Annular Elastolytic Giant Cell Granuloma and Granuloma Annulare? Case Reports in Dermatological Medicine 2012; Electronic links: http://www. ncbi. nlm. nih. gov/pmc/journals/1951 (date of treatment 17.04.2014).Limas C. The spectrum of primary cutaneous elastolytic granulomas and their distinction from granuloma annulare: a clinicopathological analysis. Histopathology 2004; 44 (3): 277-82.Zkaya-bayazit E.O., Kbabani N.Y., Baykal C. et al. Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine. Br J Dermatol 1999; 140: 525-30.Vehring K.H., Bonsmann G., Brocker E.B. et al. Das anulare elastolytische Riesenzellgranulomeine - eine Differentialdiagnose kutaner Granulomatosen. Hautarzt 1991; 42: 391-5.Ackerman A.B., Chongchitnant N., Sanchez J. et al. Histologic Diagnosis of Inflammatory Skin Diseases: An Algorithmic Method Based on Pattern Analysis. Williams & Wilkins, Baltimore, Md, USA, 2nd edition, 1997.Da Veiga Gonsalves R.R., Da Oliveira Viana F., Da Fonseca D.M. Annular elastolytic giant cell granuloma - Case report. An Bras Dermatol 2011; 86 (4): 69-71.Djilali-Bouzina F., Grange F., Krzisch S. et al. Annular elastolytic giant cell granuloma. Ann Dermatol Venereol 2010; 137 (8-9): 536-40.Dowling G.B., Wilson-Jones E. Atypical (annular) necrobiosis lipoidica of the face and scalp. Dermatologica 1967; 135: 11-26.Kumari R., Thappa D.M., Chougule A. et al. Granuloma multiforme: a report from India. Indian J Dermatol Venereol Leprol 2009; 75 (3): 296-9.Pock L., Blazkova J., Caloudova H. et al. Annular elastolytic giant cell granuloma causes an irreversible disappearance of the elastic fibres. J Eur Acad Dermatol Venereol 2004; 18: 365-68.