Vestnik dermatologii i venerologiiVestnik dermatologii i venerologiiВестник дерматологии и венерологии0042-46092313-6294Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov53510.25208/0042-4609-2019-95-6-68-77DRUG TREATMENT IN DERMATOVENEROLOGYФАРМАКОТЕРАПИЯ В ДЕРМАТОВЕНЕРОЛОГИИGuselkumab in the treatment of patients with plaque psoriasis of moderate and severe severity: Efficacy and safety of interleukin-23 blockadeГуселькумаб в терапии больных бляшечным псориазом средней и тяжелой степени тяжести: эффективность и безопасность блокады интерлейкина-23ChikinV. V.ЧикинВ. В.
Russian Federation

Dr. Sci. (Med.), Leading Researcher, Department of Dermatology

Korolenko str., 3, bldg 6, Moscow, 107076, Russian Federation

д.м.н., ведущий научный сотрудник отдела дерматологии 

107076, Российская Федерация, г. Москва, ул. Короленко, д. 3, стр. 6

chikin@cnikvi.ruState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationГосударственный научный центр дерматовенерологии и косметологии Министерства здравоохранения Российской Федерации2612201995668772601202026012020Copyright ©; 2019, Chikin V.V.Copyright ©; 2019, Чикин В.В.2019Chikin V.V.Чикин В.В.https://creativecommons.org/licenses/by/4.0https://vestnikdv.ru/jour/article/view/535

Materials and methods. In this paper, we review publications on the significance of interleukin-(IL)-23 in the pathogenesis of plaque psoriasis and analyse the results of the 1st and 2nd phase clinical studies, as well as the 3rd phase comparative studies VOYAGE 1, VOYAGE 2, NAVIGATE and ECLIPSE on the efficacy and safety of Guselkumab — a blocker of the p19 subunit in IL-23. The review was conducted using the scientific literature databases PubMed and RSCI.Results. The high efficiency and safety of Guselkumab in the treatment of patients with plaque psoriasis is demonstrated. The PASI 90 value during Guselkumab treatment reached 73.3 % and 80.2 % at the 24th and 16th week (VOYAGE 1). The therapeutic effect persisted following treatment for 48 weeks. It is shown that Guselkumab therapy is effective in patients having undergone unsuccessful therapy with other genetically engineered biological preparations. The reviewed comparative studies show a higher  therapeutic efficacy of Guselkumab compared to TNF-α blockers, IL-12/23 p40 subunit, IL-17. The incidence of adverse events during therapy using Guselkumab and other biological drugs used in comparative studieswas low and comparable.Conclusion. The IL-23 subunit p19 blocker Guselkumab is an effective and safe drug for the treatment of patients with plaque psoriasis of moderate and severe severity.

Материал и методы. Представлен обзор литературы, в котором рассматривается значение интерлейкина-(ИЛ)-23 в патогенезе бляшечного псориаза и анализируются результаты клинических исследований 1-й и 2-й фаз, а также сравнительных исследований 3-й фазы VOYAGE 1, VOYAGE 2, NAVIGATE и ECLIPSE, в которых оценивалась эффективность и безопасность блокатора субъединицы p19 ИЛ-23 гуселькумаба. Для подготовки обзора были использованы базы данных научной литературы PubMed и РИНЦ.Результаты. Продемонстрирована высокая эффективность и безопасность гуселькумаба в терапии больных бляшечным псориазом. Значение PASI 90 на 16-й неделе терапии гуселькумабом достигало 73,3 %, на 24-й неделе лечения — 80,2 % (исследование VOYAGE 1). При продолжении лечения в течение 48 недель терапевтический эффект сохранялся. Показана высокая эффективность терапии гуселькумабом больных, у которых ранее была неэффективной терапия другими генноинженерными биологическими препаратами. В сравнительных исследованиях показана более высокая терапевтическая эффективность гуселькумаба по сравнению с блокаторами ФНО-α, субъединицы p40 ИЛ-12/23, ИЛ-17. Частота развития нежелательных явлений во время терапии гуселькумабом и другими биологическими препаратами, использовавшимися в сравнительных исследованиях, была невысокой и сопоставимой.Заключение: блокатор субъединицы p19 ИЛ-23 гуселькумаб представляет собой эффективное и безопасное средство для лечения больных бляшечным псориазом средней и тяжелой степени тяжести.

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