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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">549</article-id><article-id pub-id-type="doi">10.25208/vdv549-2020-96-1-34-44</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL PRACTICE GUIDELINES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Combination treatment of disseminated granuloma annulare</article-title><trans-title-group xml:lang="ru"><trans-title>Комбинированная терапия диссеминированной формы кольцевидной гранулемы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Karamova</surname><given-names>Arfenya E.</given-names></name><name xml:lang="ru"><surname>Карамова</surname><given-names>Арфеня Эдурдовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med)., Head of the Department of Dermatology</p></bio><bio xml:lang="ru"><p>к.м.н., заведующий отделом дерматологии</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Znamenskaya</surname><given-names>Lyudmila F.</given-names></name><name xml:lang="ru"><surname>Знаменская</surname><given-names>Людмила Федоровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Leading Researcher, Department of Dermatology</p></bio><bio xml:lang="ru"><p>д.м.н., ведущий научный сотрудник отдела дерматологии</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Svishchenko</surname><given-names>Svetlana I.</given-names></name><name xml:lang="ru"><surname>Свищенко</surname><given-names>Светлана Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med)., Head of the Department of clinical dermatology</p></bio><bio xml:lang="ru"><p>к.м.н., заведующий отделением клинической дерматологии</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhilova</surname><given-names>Mar'yana B.</given-names></name><name xml:lang="ru"><surname>Жилова</surname><given-names>Марьяна Борисовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Head of the department of physical therapy</p></bio><bio xml:lang="ru"><p>д.м.н., заведующий физиотерапевтическим отделением</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nefedova</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Нефедова</surname><given-names>Мария Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Junior Researcher, Dermatology Department</p></bio><bio xml:lang="ru"><p>младший научный сотрудник отдела дерматологии</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pugner</surname><given-names>Anna S.</given-names></name><name xml:lang="ru"><surname>Пугнер</surname><given-names>Анна Степановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dermatovenerologist, Department of clinical dermatology</p></bio><bio xml:lang="ru"><p>врач-дерматовенеролог отделения клинической дерматологии</p></bio><email>pugner@cnikvi.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">State Research Center of Dermatovenereology and Cosme-tology, Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Государственный научный центр дерматовенерологии и косметологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-03-30" publication-format="electronic"><day>30</day><month>03</month><year>2020</year></pub-date><volume>96</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>34</fpage><lpage>44</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Karamova A.E., Znamenskaya L.F., Svishchenko S.I., Zhilova M.B., Nefedova M.A., Pugner A.S.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, Карамова А.Э., Знаменская Л.Ф., Свищенко С.И., Жилова М.Б., Нефедова М.А., Пугнер А.С.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Karamova A.E., Znamenskaya L.F., Svishchenko S.I., Zhilova M.B., Nefedova M.A., Pugner A.S.</copyright-holder><copyright-holder xml:lang="ru">Карамова А.Э., Знаменская Л.Ф., Свищенко С.И., Жилова М.Б., Нефедова М.А., Пугнер А.С.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/549">https://vestnikdv.ru/jour/article/view/549</self-uri><abstract xml:lang="en"><p><bold>Purpose.</bold> To present the results of the treatment of disseminated form of granuloma annulare with remote long-wave ultraviolet therapy and low level laser therapy.</p> <p><bold>Material and methods.</bold> Two female patients at the age of 50 and 53 years with complaints of generalised eruptions on the skin of the trunk, upper and lower limbs and a histologically confirmed diagnosis were treated using a combination of remote long-wave ultraviolet therapy and low level laser therapy of infrared spectrum. 16 sessions of remote long-wave ultraviolet therapy and 10 sessions of low level laser therapy were conducted directly on the lesions. Considering the multidirectionality of the mechanisms of action of phototherapy and laser therapy, the procedures were carried out on different days or with many hours long intervals.</p> <p><bold>Results.</bold> Combined use of the remote long-wave ultraviolet therapy and laser therapy led to a significant improvement by the 21st day of the treatment. No side effects were noticed during the treatment, tolerance of the sessions was good.</p> <p><bold>Conclusion.</bold> Combined use of the remote long-wave ultraviolet therapy and low level laser therapy of infrared spectrum is effective in treatment of disseminated form of granuloma annulare.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель.</bold> Представить результаты лечения диссеминированной формы кольцевидной гранулемы с применением дальней длинноволновой ультрафиолетовой терапии и низкоинтенсивной лазерной терапии.</p> <p><bold>Материал и методы.</bold> 2 пациенткам в возрасте 50 и 53 лет, обратившимся с жалобами на распространенные высыпания на коже туловища, верхних и нижних конечностей и гистологически верифицированным диагнозом, проведено комбинированное лечение с применением дальней длинноволновой ультрафиолетовой терапии и низкоинтенсивной лазерной терапии инфракрасного спектра. Проведено 16 процедур общей дальней длинноволновой ультрафиолетовой терапии и 10 процедур низкоинтенсивной лазерной терапии контактно на очаги поражения. Учитывая разнонаправленность механизмов действия методов фототерапии и лазеротерапии, процедуры проводились в разные дни либо с многочасовым интервалом.</p> <p><bold>Результаты.</bold> При использовании метода дальней длинноволновой ультрафиолетовой терапии в комбинации с лазерной терапией отмечено существенное улучшение к 21-му дню терапии. Побочных эффектов в процессе лечения не отмечалось, переносимость процедур была хорошая.</p> <p><bold>Заключение.</bold> Комбинированное применение дальней длинноволновой ультрафиолетовой терапии и низкоинтенсивной лазерной терапии инфракрасного спектра является эффективным при лечении диссеминированной формы кольцевидной гранулемы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>granuloma annulare</kwd><kwd>PUVA-therapy</kwd><kwd>UVA1-phototherapy</kwd><kwd>low-level laser radiation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кольцевидная гранулема</kwd><kwd>ПУВА-терапия</kwd><kwd>УФА-1 терапия</kwd><kwd>низкоинтенсивное лазерное излучение</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Харчилава М. Г., Хайрутдинов В. Р., Белоусова И. Э., Самцов А. В. Клинико-патоморфологические изменения кожи при кольцевидной гранулеме. Вестник дерматологии и венерологии. 2019; 95 (2): 8—14. [Kharchilava M. 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