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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Vestnik dermatologii i venerologii</journal-id><journal-title-group><journal-title xml:lang="en">Vestnik dermatologii i venerologii</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник дерматологии и венерологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0042-4609</issn><issn publication-format="electronic">2313-6294</issn><publisher><publisher-name xml:lang="en">Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">580</article-id><article-id pub-id-type="doi">10.25208/vdv580</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Innovations in the external therapy of acne</article-title><trans-title-group xml:lang="ru"><trans-title>Инновации в наружной терапии акне</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tlish</surname><given-names>M M</given-names></name><name xml:lang="ru"><surname>Тлиш</surname><given-names>М М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Katkhanova</surname><given-names>O A</given-names></name><name xml:lang="ru"><surname>Катханова</surname><given-names>О А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kuznetsova</surname><given-names>T G</given-names></name><name xml:lang="ru"><surname>Кузнецова</surname><given-names>Т Г</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Naatyzh</surname><given-names>Zh Yu</given-names></name><name xml:lang="ru"><surname>Наатыж</surname><given-names>Ж Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kuban State Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Кубанский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2013</year></pub-date><volume>89</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2013)</issue-title><issue-title xml:lang="ru">№2 (2013)</issue-title><fpage>79</fpage><lpage>83</lpage><history><date date-type="received" iso-8601-date="2020-03-11"><day>11</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Tlish M.M., Katkhanova O.A., Kuznetsova T.G., Naatyzh Z.Y.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Тлиш М.М., Катханова О.А., Кузнецова Т.Г., Наатыж Ж.Ю.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Tlish M.M., Katkhanova O.A., Kuznetsova T.G., Naatyzh Z.Y.</copyright-holder><copyright-holder xml:lang="ru">Тлиш М.М., Катханова О.А., Кузнецова Т.Г., Наатыж Ж.Ю.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnikdv.ru/jour/article/view/580">https://vestnikdv.ru/jour/article/view/580</self-uri><abstract xml:lang="en"><p>Goal. To assess the clinical efficacy of a monotherapy with the use of products belonging to the Hyseac line for the treatment of light acne. Materials and methods. The study involved 28 patients with light acne, who were administered products belonging to the Hyseac line as a monotherapy. The dynamics of the skin processes was assessed visually (S. Liden’s acne general severity scale) and with the use of instrumental methods — sebometry (Callegari SOFT 5.5). Results. High efficacy of the administered therapy was registered in 39% of the subjects, substantial improvement was recorded in 53% of the subjects, improvement — in 8% of the subjects while no effect was registered in 0% of the subjects. Conclusion. The drug demonstrated high clinical efficacy, good tolerance and absence of any adverse effects, which makes it possible to recommend products belonging to the Hyseac line as a monotherapy and concomitant treatment of light acne.</p></abstract><trans-abstract xml:lang="ru"><p>Цель. Оценить клиническую эффективность монотерапии средствами гаммы Исеак в лечении акне легкой степени тяжести. Материал и методы. Под наблюдением находились 28 пациентов с акне легкой степени тяжести, которые получали в виде монотерапии средства гаммы Исеак. Динамику кожного процесса оценивали визуально (шкала общей тяжести угрей ОТУ S. Liden) и с помощью инструментальных методов — себуметрии (аппарат Callegari SOFT 5,5). Результаты. Высокая эффективность проведенной терапии зарегистрирована у 39% больных, значительное улучшение — у 53%, улучшение — у 8%, отсутствие эффекта — у 0%. Заключение. Продемонстрирована высокая клиническая эффективность, хорошая переносимость, отсутствие побочных эффектов, что позволяет рекомендовать гамму Исеак для монотерапии и комбинированного лечения акне легкой степени тяжести.</p></trans-abstract><kwd-group xml:lang="en"><kwd>light acne</kwd><kwd>Hyseac line</kwd><kwd>high clinical efficacy</kwd><kwd>good tolerance</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>акне</kwd><kwd>легкая степень тяжести</kwd><kwd>гамма Исеак</kwd><kwd>высокая клиническая эффективность</kwd><kwd>хорошая переносимость</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Akne i rozatsea. Pod red. N.N. Potekaeva. M: Binom 2007; 215.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kubanova A.A., Samsonov V.A., Zabnenkova O.V. Sovremennye osobennosti patogeneza i terapii akne. Vestn dermatol i venerol 2003; 1: 9—16.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Josipovitch G., Tang M., Dawn F.G. et al. Study of psychological stress, sebum production and acne vulgaris in adolescencents. Acta Dermato-Venerologica 2007; 87: 135—139.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Esterbauer H., Gebicki J., Puhl H. The role of lipid peroxidation and antioxidants in oxidative modification of LDF. Free Radic Biol Med 1992; 13: 341—390.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Plewig G. Acne and rosacea / G. Plewig, A.M. Kligman. Berlin 1993; 555—673.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>ONeil D.A., Porter E.M., Elewaut D. et al. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999; 163: 6718—24.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999; 274: 17406—9.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Skripkin Yu.K. i dr. Kozhnye i venericheskie bolezni: rukovodstvo dlya vrachey. M: Meditsina 1995; 2: 17—19.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Zimina I.V., Lopukhin Yu.M., Arion V.Ya. Kozha kak immunnyy organ: kletochnye elementy i tsitokiny. Immunologiya 1994; 1: 8—13.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Strcinlein J.W. Skin — associated limfoid tissue (SALT): original and function. J Invest Dermatol 1983; 80: 12—16.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Yutskovskaya Ya.A., Mel'nikova E.V., Metlyaeva N.B. Otsenka sostoyaniya psikhoemotsional'noy sfery u bol'nykh akne. Vestn dermatol i venerol 2005; 3: 48—49.</mixed-citation></ref></ref-list></back></article>
